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Total 28 results found since Jan 2013.

Data-independent acquisition-based quantitative proteomic analysis of m.3243A>G MELAS reveals novel potential pathogenesis and therapeutic targets
The pathogenesis of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS) syndrome has not been fully elucidated. The m.3243A > G mutation which is responsible for 80% MELAS patients affects proteins with undetermined functions. Therefore, we performed quantitative proteomic analysis on skeletal muscle specimens from MELAS patients. We recruited 10 patients with definitive MELAS and 10 age- and gender- matched controls. Proteomic analysis based on nanospray liquid chromatography-mass spectrometry (LC-MS) was performed using data-independent acquisition (DIA) method and differentially ...
Source: Medicine - October 14, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Glucose-6-phosphate Dehydrogenase Deficiency and Intracranial Atherosclerosis Stenosis in Stroke Patients
CONCLUSION: Stroke patients with G6PD deficiency have a higher prevalence and ICAS burden than those with normal G6PD, particularly those who are male, older, and hypertensive.PMID:35608963 | DOI:10.1111/ene.15418
Source: Atherosclerosis - May 24, 2022 Category: Cardiology Authors: Jianle Li Yicong Chen Zilin Ou Yusheng Zhang Zhijian Liang Weisheng Deng Hao Chen Weixian Huang Yingxin He Shihui Xing Jian Yu Jinsheng Zeng Source Type: research

Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats
Brain Res Bull. 2022 May 16;185:162-173. doi: 10.1016/j.brainresbull.2022.05.008. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH), a type of hemorrhagic stroke, is a neurological emergency with high morbidity and mortality. Early brain injury (EBI) after SAH is the leading cause of poor prognosis in SAH patients. TRX system is a NADPH-dependent antioxidant system which is composed of thioredoxin reductase (TRXR), thioredoxin (TRX). The pentose phosphate pathway (PPP), a pathway through which glucose can be metabolized, is a major source of NADPH. Thioredoxin 1 (TRX1) is a member of thioredoxin system mainly loc...
Source: Brain Research Bulletin - May 19, 2022 Category: Neurology Authors: Xiaodong Wang Zongqi Wang Jie Wu Lingling Wang Xiang Li Haitao Shen Haiying Li Jianguo Xu Wen Li Gang Chen Source Type: research

Association between aspirin-induced hemoglobin decline and outcome after acute ischemic stroke in G6PD-deficient patients
CONCLUSION: Hemoglobin decrease with bilirubin increase after aspirin treatment in patients with G6PD deficiency suggests hemolysis, which may influence stroke prognosis. The risk of hemoglobin decline should be carefully monitored in G6PD-deficient patients with ischemic stroke taking aspirin.PMID:34369077 | DOI:10.1111/cns.13711
Source: CNS Neuroscience and Therapeutics - August 9, 2021 Category: Neuroscience Authors: Yicong Chen Jianle Li Zilin Ou Yusheng Zhang Zhijian Liang Weisheng Deng Weixian Huang Fubing Ouyang Jian Yu Shihui Xing Jinsheng Zeng Source Type: research

A Dual Role of ATM in Ischemic Preconditioning and Ischemic Injury.
In conclusion, our data show the dual role of ATM in neuronal ischemic preconditioning and lethal ischemic injury, involving in the protection of ischemic preconditioning, but promoting neuronal death in lethal ischemic injury. Thus, the present study provides new opportunity for the treatment of ischemic stroke. PMID: 31845160 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - December 15, 2019 Category: Cytology Authors: Xie GH, Dai HJ, Liu F, Zhang YP, Zhu L, Nie JJ, Wu JH Tags: Cell Mol Neurobiol Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II α Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase.
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IIα Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase. Neurochem Res. 2019 Mar 27;: Authors: Wei Y, Wang R, Teng J Abstract Ischemic stroke is a leading cause of mortality and morbidity worldwide, and oxidative stress plays a significant role in the ischemia stage and reperfusion stage. Previous studies have indicated that both calcium/calmodulin-dependent protein kinase II (CaMKII) and glucose 6-phosphate dehydrogenase (G6PD) are involved in the oxidative stress. Thus, the aim of this st...
Source: Neurochemical Research - March 26, 2019 Category: Neuroscience Authors: Wei Y, Wang R, Teng J Tags: Neurochem Res Source Type: research

Etiology and Outcomes of Thrombotic Microangiopathies.
CONCLUSIONS: Secondary thrombotic microangiopathies represent the majority of thrombotic microangiopathies. Multiple thrombotic microangiopathies causes are present in one half of secondary thrombotic microangiopathies. The risks of dialysis, neurologic and cardiac complications, and death vary by the cause of thrombotic microangiopathies. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_03_12_CJASNPodcast_19_04_.mp3. PMID: 30862697 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 11, 2019 Category: Urology & Nephrology Authors: Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM Tags: Clin J Am Soc Nephrol Source Type: research