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Cost-Effectiveness Analysis of Initiating Type  2 Diabetes Therapy with a Sodium–Glucose Cotransporter 2 Inhibitor Versus Conventional Therapy in Japan
ConclusionOur results suggest that initiating T2DM treatment with SGLT2i, aimed at managing cardiovascular and renal complications from the early stages of diabetes, can improve the clinical outcome and reduce cost burden of T2DM.
Source: Diabetes Therapy - June 16, 2022 Category: Endocrinology Source Type: research

Incidence of atrial fibrillation in elderly patients with type 2 diabetes mellitus
CONCLUSIONS: Annually, 1 in 200 elderly Japanese patients with T2D are estimated to develop AF. Because elderly patients with T2D with AF are at an elevated risk for CVD, careful follow-up of this patient subgroup is necessary.TRIAL REGISTRATION NUMBER: NCT00110448.PMID:35361621 | DOI:10.1136/bmjdrc-2021-002745
Source: Atherosclerosis - April 1, 2022 Category: Cardiology Authors: Chisa Matsumoto Hisao Ogawa Yoshihiko Saito Sadanori Okada Hirofumi Soejima Mio Sakuma Izuru Masuda Masafumi Nakayama Naofumi Doi Hideaki Jinnouchi Masako Waki Takeshi Morimoto Source Type: research

Factors Influencing Long-Term Blood Flow in Extracranial-to-Intracranial Bypass for Symptomatic Internal Carotid Artery Occlusive Disease: A Quantitative Study
CONCLUSION: Double anastomoses and cilostazol resulted in long-term STA blood flow preservation. No recurrence of cerebral infarction was noted in either STA hypoperfusion or occlusion cases.
Source: Neurosurgery - March 24, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Cerebrovascular Source Type: research

Comparison of the effects on cardiovascular events between use of metformin and dipeptidyl peptidase-4 inhibitors as the first-line hypoglycaemic agents in Japanese patients with type 2 diabetes mellitus: a claims database analysis
Conclusions Patients who received metformin as first-line therapy may have reduced cardiovascular events than those receiving DPP-4i. This study conforms to previous Japanese database studies, despite the consideration of its limitation being an observational design.
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Nishimura, R., Takeshima, T., Iwasaki, K., Aoi, S. Tags: Open access, Diabetes and Endocrinology Source Type: research

Premature Atrial Contractions and Their Determinants in a General Population of Japanese Men
CONCLUSIONS: PAC frequency was independently associated with age, height, smoking, alcohol consumption, heart rate, physical activity, and triglycerides.PMID:35185078 | DOI:10.1253/circj.CJ-21-0872
Source: Circulation Journal - February 21, 2022 Category: Cardiology Authors: Sabrina Ahmed Takashi Hisamatsu Aya Kadota Akira Fujiyoshi Hiroyoshi Segawa Sayuki Torii Naoyuki Takashima Keiko Kondo Yoshihisa Nakagawa Hirotsugu Ueshima Katsuyuki Miura SESSA Research Group Source Type: research

Manifestation of Heart Failure and Chronic Kidney Disease are Associated with Increased Mortality Risk in Early Stages of Type  2 Diabetes Mellitus: Analysis of a Japanese Real-World Hospital Claims Database
ConclusionsThe high incidence of CKD or HF manifestation can contribute to the augmented mortality risk in patients in the early stages of T2DM compared with patients without T2DM. These findings highlight the importance of early interventions for preventing/treating CKD and HF to improve the prognosis of patients with T2DM.
Source: Diabetes Therapy - January 10, 2022 Category: Endocrinology Source Type: research

Delays in Presentation Time Under the COVID-19 Epidemic in Patients With Transient Ischemic Attack and Mild Stroke: A Retrospective Study of Three Hospitals in a Japanese Prefecture
Conclusions: The COVID-19 epidemic might increase the ODT of patients with TIA/mild stroke.
Source: Frontiers in Neurology - October 27, 2021 Category: Neurology Source Type: research

Diabetes Mellitus Modifies the Association of Serum Triglycerides with Ischemic Cardiovascular Disease Mortality: The Ibaraki Prefectural Health Study (IPHS)
CONCLUSION: The impact of high serum triglyceride levels on the risk of ischemic cardiovascular disease mortality was confined to participants with diabetes mellitus.PMID:34565764 | DOI:10.5551/jat.63081
Source: Journal of Atherosclerosis and Thrombosis - September 27, 2021 Category: Cardiology Authors: Kazumasa Yamagishi Hiroyasu Iso Toshimi Sairenchi Fujiko Irie Nobue Takizawa Ai Koba Takuji Tomizawa Hitoshi Ota Source Type: research

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