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Total 2168 results found since Jan 2013.

Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study
DISCUSSION: A higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low-medium mental stress group. This finding suggests the importance of having life enjoyment by managing mental stress for reducing risk of disabling dementia.PMID:37718836 | DOI:10.1093/geronb/gbad129
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Tomokazu Tajima Ai Ikeda Takeshi Tanigawa Hiroyasu Iso Kazumasa Yamagishi Takumi Matsumura Nobufumi Yasuda Manami Inoue Shoichiro Tsugane Norie Sawada Japan Public Health Center –Based Study Group Source Type: research

Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack
This study was approved by the Ethical Committee of the University of Yamanashi as the central ethical committee in agreement with the ethical committees of all collaborative stroke centres. Informed consent will be obtained by an opt-out form from the patients at each stroke centre according to the Ethical Guidelines for Medical and Biological Research Involving Human Subjects by the Japanese Ministry of Health, Labour and Welfare. Trial registration numbers NCT05579405, UMIN000048954
Source: BMJ Open - September 18, 2023 Category: General Medicine Authors: Uchiyama, S., Suzuki-Inoue, K., Wada, H., Okada, Y., Hirano, T., Nagao, T., Kinouchi, H., Itabashi, R., Hoshino, H., Oki, K., Honma, Y., Ito, N., Sugimori, H., Kawamura, M. Tags: Open access, Diagnostics Source Type: research

Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank
This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS.
Source: Journal of the Neurological Sciences - September 13, 2023 Category: Neurology Authors: Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Ma Source Type: research

Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news

Spontaneous middle cerebral artery dissection: a series of six cases and literature review
AbstractMiddle cerebral artery (MCA) dissection is rare, and various clinical presentations, including hemorrhage, ischemia, or comorbidities, and the changes in imaging findings over time hinder treatment decisions. The European Stroke Organization guidelines exclude MCA dissection. Few cases have been reported with no review of the relevant literature. Therefore, we reviewed the relevant literature and our own experience with non-traumatic MCA dissection cases to determine appropriate treatment strategies. At our institution and affiliated institutions, we encountered six cases of MCA dissection —five with infarction a...
Source: Neurosurgical Review - September 7, 2023 Category: Neurosurgery Source Type: research

Access to mechanical thrombectomy and ischemic stroke mortality in Japan: a spatial ecological study
ConclusionAccess to mechanical thrombectomy was estimated, and regional differences were observed. The relationship between accessibility and IS mortality is unknown; however, regardless of accessibility, municipalities with a high proportion of workers in secondary industries and a small proportion with bachelor’s degrees or above are at risk of death from stroke.
Source: Frontiers in Neurology - September 5, 2023 Category: Neurology Source Type: research

Prediction of the 4-Year Incidence Risk of Ischemic Stroke in Healthy Japanese Adults: The Fukushima Health Database
CONCLUSIONS: The 4-year risk prediction model revealed a good performance for IS incidence, and risk scores could be used to estimate individual incidence risk of IS. Updated models with additional confirmed risk variables may be needed.PMID:37661424 | DOI:10.5551/jat.64018
Source: Journal of Atherosclerosis and Thrombosis - September 4, 2023 Category: Cardiology Authors: Enbo Ma Tetsuya Ohira Makoto Miyazaki Maiko Fukasawa Masayo Yoshimoto Tomonori Suzuki Ayako Furuyama Mariko Kataoka Seiji Yasumura Mitsuaki Hosoya Source Type: research