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Condition: Dementia
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Total 174 results found since Jan 2013.

Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts...
Source: Stroke - January 22, 2017 Category: Neurology Authors: Eric E. Smith, Gustavo Saposnik, Geert Jan Biessels, Fergus N. Doubal, Myriam Fornage, Philip B. Gorelick, Steven M. Greenberg, Randall T. Higashida, Scott E. Kasner, Sudha Seshadri Tags: Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment Brief Reports
Conclusions— The prevalence of amyloid-pathology in patients with PS-MCI is not increased when compared with cognitively healthy stroke survivors and to recent estimates for cognitively healthy elderly subjects. Factors other than amyloid-pathology likely contribute to the development of PS-MCI. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01334749.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Wollenweber, F. A., Darr, S., Muller, C., Duering, M., Buerger, K., Zietemann, V., Malik, R., Brendel, M., Ertl-Wagner, B., Bartenstein, P., Rominger, A., Dichgans, M. Tags: Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET, Cerebrovascular Disease/Stroke, Cognitive Impairment Brief Reports Source Type: research

The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Frank A. Wollenweber, Vera Zietemann, Axel Rominger, Christian Opherk, Anna Bayer‐Karpinska, Andreas Gschwendtner, Lisa Coloma Andrews, Katharina Bürger, Marco Duering, Martin Dichgans Tags: Protocols Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Determinants of post‐stroke cognitive impairment: analysis from VISTA
ConclusionsBesides well‐known determinants of PSCI such as age, stroke severity and the presence of vascular risk factors, also leg paralysis is associated with subsequent of PSCI up to 3 years after stroke.
Source: Acta Neurologica Scandinavica - July 14, 2016 Category: Neurology Authors: F. Arba, T. Quinn, G. J. Hankey, D. Inzitari, M. Ali, K. R. Lees, Tags: Original Article Source Type: research

Determinants of post ‐stroke cognitive impairment: analysis from VISTA
ConclusionsBesides well‐known determinants of PSCI such as age, stroke severity and the presence of vascular risk factors, also leg paralysis is associated with subsequent of PSCI up to 3 years after stroke.
Source: Acta Neurologica Scandinavica - July 12, 2016 Category: Neurology Authors: F. Arba, T. Quinn, G. J. Hankey, D. Inzitari, M. Ali, K. R. Lees, Tags: Original Article Source Type: research

Calcium supplements linked to post-stroke dementia in women
Conclusion The media paint this as a troubling study for older women who take calcium to strengthen their bones. However the small size of the study (only 98 women took calcium supplements, and only 14 of those got dementia) and its observational nature mean that we cannot rely on the results. As the researchers mention, it is possible that those taking supplements were less healthy than those that didn't in some unmeasured way. Further research may improve our confidence in these results. Broken bones are not a trivial matter for older people – a broken hip can be the difference between being able to live independentl...
Source: NHS News Feed - August 18, 2016 Category: Consumer Health News Tags: Neurology Medication Older people Source Type: news

UCLA brain-imaging tool and stroke risk test help identify cognitive decline early
UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia.   The connection between stroke risk and cognitive decline has been well established by previous research. Individuals with higher stroke risk, as measured by factors like high blood pressure, have traditionally performed worse on tests of memory, attention and abstract reasoning.   The current small study demonstrated that not only stroke risk, but also the burden of plaques and tangles, as measured by a UCLA brain scan, may influence c...
Source: UCLA Newsroom: Health Sciences - April 3, 2013 Category: Universities & Medical Training Source Type: news

Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research

Microbleeds, Mortality, and Stroke in Alzheimer Disease The MISTRAL Study
Conclusions and RelevanceIn patients with AD, the presence of nonlobar microbleeds was associated with an increased risk for cardiovascular events and cardiovascular mortality. Patients with lobar microbleeds had an increased risk for stroke and stroke-related mortality, indicating that these patients should be treated with the utmost care.
Source: JAMA Neurology - March 23, 2015 Category: Neurology Source Type: research

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke
Conclusions: The results support the notion of a predominant role of brainstem injury in the development of RBD and suggest that patients with brainstem infarcts RBD should be evaluated by a clinical neurologist.
Source: BMC Neurology - April 23, 2014 Category: Neurology Authors: Wai TangDirk HermannYang ChenHua LiangXiang LiuWinnie ChuAnil AhujaJill AbrigoVincent MokGabor UngvariKa Wong Source Type: research

Prevalence and predictors of anxiety in an African sample of recent stroke survivors
ConclusionsOne in five recent stroke survivors in SSA has clinically significant anxiety, and well over 70% of those with anxiety also have depression. Future studies will need to determine what specific impact post‐stroke anxiety may have on post‐stroke clinical processes and outcomes.
Source: Acta Neurologica Scandinavica - April 18, 2017 Category: Neurology Authors: A. Ojagbemi, M. Owolabi, R. Akinyemi, O. Arulogun, J. Akinyemi, O. Akpa, F. S. Sarfo, E. Uvere, R. Saulson, S. Hurst, B. Ovbiagele Tags: ORIGINAL ARTICLE Source Type: research

Cerebrovascular disease affects brain structural integrity long before clinically overt strokes
In the current issue of Neurology®, Werden et al.1 examined a group of patients experiencing first-ever or recurrent stroke to understand the relationships between stroke and cortical structural integrity. They performed 3T magnetic resonance scanning within 6 weeks of the most recent stroke and found that stroke patients had smaller hippocampal volumes and greater white matter hyperintensity (WMH) volume compared to controls. Because of the short time lag from stroke to scan, the authors do not believe that the index stroke itself caused the shrinkage in the hippocampus; rather, they believe that the stroke and the st...
Source: Neurology - July 10, 2017 Category: Neurology Authors: Knopman, D. S., Hooshmand, B. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia EDITORIALS Source Type: research