Filtered By:
Condition: Dementia
Countries: Japan Health

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 67 results found since Jan 2013.

Analyzing Cost-Effectiveness of Allocating Neurointerventionist for Drive and Retrieve System for Patients with Acute Ischemic Stroke
The cost of stroke treatment accounts for approximately 6% of Japan's national medical expenditure,1 and stroke is the second most common condition, after dementia, that results in a requirement for long-term care. Thus, stroke has a significant impact on society.2 Cerebral infarction accounts for 60% or more of stroke cases.3 Systematic provision of highly equitable and efficient treatment for cerebral infarction is an important policy issue, such as the enactment of the Stroke and Cardiovascular Disease Control Act in December 2018 in Japan, as part of an effort to enhance provision of treatment for cerebral infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2021 Category: Neurology Authors: Yasuhiro Morii, Toshiya Osanai, Kensuke Fujiwara, Takumi Tanikawa, Kiyohiro Houkin, Songzi Gu, Katsuhiko Ogasawara Source Type: research

Association Between Oral Anticoagulants and Stroke Severity at Onset in Elderly Patients with Cardioembolic Stroke Due to Non-Valvular Atrial Fibrillation
The prevention of cardioembolic stroke is an important public health priority in Japan due to its high prevalence in elderly individuals. Compared to their younger counterparts, elderly patients with cardioembolic stroke are more likely to have multiple comorbidities, a higher risk of serious complications, such as pneumonia and heart failure, and cognitive impairments (e.g., dementia or delirium), which may adversely affect their ability to participate in active rehabilitation. These factors negatively affect clinical outcomes, and many elderly stroke survivors require long-term care despite the early implementation of intensive therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - December 25, 2021 Category: Neurology Authors: Ichiro Deguchi, Takashi Osada, Shinichi Takahashi Source Type: research

Association between Early Cognitive Impairment and Short-Term Functional Outcome in Acute Ischemic Stroke
Conclusions: Our findings suggest that PSCI, as well as PreSD, is possibly associated with the development of poor functional outcome in the acute care phase of ischemic stroke, and this association continues thereafter.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 3, 2022 Category: Neurology Source Type: research

Cardiovascular disease, a major global burden: Epidemiology of stroke and ischemic heart disease in Japan
Glob Health Med. 2021 Dec 31;3(6):358-364. doi: 10.35772/ghm.2020.01113.ABSTRACTJapan ranks the highest globally, in terms of longevity. The average life expectancy was 81.4 years for men and 87.5 years for women in 2019. Such success in health is attributable to the substantial reduction in age-standardized mortality from cardiovascular diseases, especially stroke (136 per 105 in 1980 and 24 per 105 in 2015), when stroke mortality was the highest in the world between the 1960s and the 1990s. On the other hand, ischemic heart disease mortality was the lowest in the world between the 1960s and the 1980s and has continued to...
Source: Atherosclerosis - January 17, 2022 Category: Cardiology Authors: Hiroyasu Iso Source Type: research

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Associated With a Novel In-Frame Mutation in the NOTCH3 Gene in a Japanese Patient
Here, we report a case involving a 67-year-old Japanese woman with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel in-frame complex rearrangement in the NOTCH3 gene. The patient had gradually developed cognitive impairment since the occurrence of an ischemic stroke at the age of 53 years. Her mother had a history of stroke and dementia. Fluid-attenuated inversion recovery magnetic resonance imaging of the brain showed hyperintense lesions in the bilateral temporal poles, external capsules, and periventricular white matter accompanied by multiple c...
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2019 Category: Neurology Authors: Yuho Takeshi, Satoshi Suda, Takashi Shimoyama, Junya Aoki, Kentaro Suzuki, Seiji Okubo, Ikuko Mizuta, Toshiki Mizuno, Kazumi Kimura Tags: Case Report Source Type: research

Genes, Vol. 12, Pages 1955: Novel In-Frame Deletion in HTRA1 Gene, Responsible for Stroke at a Young Age and Dementia & mdash;A Case Study
We present the case of a Lithuanian male patient who had a stroke at the age of 36, experienced several transient ischemic attacks, and developed an early onset, progressing dementia. These clinical symptoms were associated with extensive leukoencephalopathy, lacunar infarcts, and microbleeds based on brain magnetic resonance imaging (MRI). A novel heterozygous in-frame HTRA1 gene deletion (NM_002775.5:c.533_535del; NP_002766.1:p.(Lys178del)) was identified by next generation sequencing. The variant was consistent with the patient’s phenotype, which could not be explained by alternative causes, appeared highl...
Source: Genes - December 7, 2021 Category: Genetics & Stem Cells Authors: Julija Grigait ė Kamil ė Šiaurytė Egl ė Audronytė Egl ė Preikšaitienė Birut ė Burnytė Erinija Pranckevi čienė Aleksandra Ekkert Algirdas Utkus Dalius Jatu žis Tags: Article Source Type: research

Stroke prevention drugs may help reduce dementia risk for atrial fibrillation patients
(European Society of Cardiology) Patients with atrial fibrillation could reduce the risk of dementia by taking stroke prevention medications, according to recommendations published online today in EP Europace1, a European Society of Cardiology journal, and presented at EHRA 2018.2 The international consensus document was also published in HeartRhythm, the official journal of the Heart Rhythm Society (HRS), and Journal of Arrhythmia, the official journal of the Japanese Heart Rhythm Society (JHRS) and the Asia Pacific Heart Rhythm Society (APHRS).
Source: EurekAlert! - Medicine and Health - March 18, 2018 Category: International Medicine & Public Health Source Type: news

Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Effectiveness and Safety of Rivaroxaban by General Practitioners 　- A Multicenter, Prospective Study in Japanese Patients With Non-Valvular Atrial Fibrillation (GENERAL)
CONCLUSIONS: The low incidence of adverse events, including stroke/SE and bleeding, in patients prescribed rivaroxaban by general practitioners supports its use as a safe and efficacious treatment in the standard clinical care of high-risk patient populations.PMID:33814525 | DOI:10.1253/circj.CJ-20-1244
Source: Circulation Journal - April 5, 2021 Category: Cardiology Authors: Kengo Kusano Nobuyoshi Sugishita Masaharu Akao Hikari Tsuji Kunihiko Matsui Shinya Hiramitsu Yutaka Hatori Hironori Odakura Hiroyuki Kamada Koji Miyamoto Hisao Ogawa Source Type: research

Relationship Between Direct Oral Anticoagulant Doses and Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation 　- ANAFIE Registry Sub-Analysis
CONCLUSIONS: Inappropriate low DOAC doses (under- or off-label dose) were not associated with stroke/SEE or major bleeding but were associated with all-cause death.PMID:37482411 | DOI:10.1253/circj.CJ-23-0143
Source: Circulation Journal - July 23, 2023 Category: Cardiology Authors: Masaharu Akao Hiroshi Inoue Takeshi Yamashita Hirotsugu Atarashi Takanori Ikeda Yukihiro Koretsune Ken Okumura Shinya Suzuki Hiroyuki Tsutsui Kazunori Toyoda Atsushi Hirayama Masahiro Yasaka Takenori Yamaguchi Satoshi Teramukai Tetsuya Kimura Yoshiyuki Mo Source Type: research