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1931 Leisure-Time Physical Activity and Risk of Cancer, CVD, Dementia and All-Cause Mortality in Adults: A Dose-Response Meta-Analysis of Prospective Studies
Conclusions These findings provide a strong basis for modelling the health impacts of walking and cycling, provided that exposure measures can be standardised and total leisure time activity estimated. Given the strongly non-linear nature of the relationship, going beyond relative risks based on walking and cycling alone is necessary.
Source: Journal of Transport and Health - June 24, 2017 Category: Occupational Health Source Type: research

Long-term hormone therapy for perimenopausal and postmenopausal women.
CONCLUSIONS: Women with intolerable menopausal symptoms may wish to weigh the benefits of symptom relief against the small absolute risk of harm arising from short-term use of low-dose HT, provided they do not have specific contraindications. HT may be unsuitable for some women, including those at increased risk of cardiovascular disease, increased risk of thromboembolic disease (such as those with obesity or a history of venous thrombosis) or increased risk of some types of cancer (such as breast cancer, in women with a uterus). The risk of endometrial cancer among women with a uterus taking oestrogen-only HT is well docu...
Source: Cochrane Database of Systematic Reviews - January 16, 2017 Category: Journals (General) Authors: Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J Tags: Cochrane Database Syst Rev Source Type: research

Age and Life-Sustaining Treatment Preferences in Parkinson Disease
Conclusions Advancing age in PD may correlate with paradoxically more aggressive goals as it relates to life-sustaining treatment preferences including cardiopulmonary resuscitation. This may reflect a response to heightened concern among older adults with PD about the potential for compromised autonomy in the setting of aging.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Jackowiak, E., Szpara, A., Kotagal, V. Tags: Parkinson's disease/Parkinsonism, Palliative care Research Source Type: research

Economic Burden of Community-Based Disease-Associated Malnutrition in the United States.
Conclusion: DAM exacts a large burden on American society. Therefore, improved diagnosis and management of community-based DAM to alleviate this burden are needed. PMID: 25249028 [PubMed - as supplied by publisher]
Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 23, 2014 Category: Nutrition Authors: Snider JT, Linthicum MT, Wu Y, LaVallee C, Lakdawalla DN, Hegazi R, Matarese L Tags: JPEN J Parenter Enteral Nutr Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam Study
AbstractWe aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. We studied 9701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45  years and over [median 64.1 years (95%-range 49.0–82.8)]. Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200 g/day), fruit (≥200 g/day), whole-grains (≥90  g/day), legumes...
Source: European Journal of Epidemiology - August 19, 2017 Category: Epidemiology Source Type: research

Acute aortic occlusion in a patient without risk factors
A 94-year-old female with a history of ischemic stroke, mild right hemiparesis, vascular dementia, breast cancer with right mastectomy, colon cancer resulting in colectomy, hyperlipidemia, and hypertension presented to the emergency department (ED) with bilateral leg pain. Patient had no smoking history, and her medications included Donepezil, Aspirin, Citalopram, Losartan, and Pantoprazole.
Source: The American Journal of Emergency Medicine - March 28, 2018 Category: Emergency Medicine Authors: Trina Stoneham, Erin L. Simon Source Type: research

Aspirin Late in Life? Healthy People May Not Need It
Millions take aspirin to prevent heart attacks, strokes and cancer. New research shows older people in good health may not need it — and should not start taking it.
Source: NYT Health - September 16, 2018 Category: Consumer Health News Authors: DENISE GRADY Tags: Aspirin Preventive Medicine Heart Elderly Colon and Colorectal Cancer Stroke Dementia New England Journal of Medicine Source Type: news

Low-Dose Aspirin Late in Life? Healthy People May Not Need It
Millions take aspirin to prevent heart attacks, strokes and cancer. New research shows older people in good health may not need it — and should not start taking it.
Source: NYT Health - September 16, 2018 Category: Consumer Health News Authors: DENISE GRADY Tags: Aspirin Preventive Medicine Heart Elderly Colon and Colorectal Cancer Stroke Dementia New England Journal of Medicine Source Type: news

Should You Take Aspirin Every Day? Here ’s What the Science Says
Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affe...
Source: TIME: Health - November 8, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs healthytime Source Type: news

IJERPH, Vol. 16, Pages 462: Health Benefits of Physical Activity Related to An Urban Riverside Regeneration
This study aimed to quantify health and health-related economic impacts associated with physical activity in an urban riverside park regeneration project in Barcelona, Spain. We used data from Barcelona local authorities and meta-analysis assessing physical activity and health outcomes to develop and apply the “Blue Active Tool”. We estimated park user health impacts in terms of all-cause mortality, morbidity (ischemic heart disease; ischemic stroke; type 2 diabetes; cancers of the colon and breast; and dementia), disability-adjusted life years (DALYs) and health-related economic impacts. We est...
Source: International Journal of Environmental Research and Public Health - February 5, 2019 Category: Environmental Health Authors: Vert Nieuwenhuijsen Gascon Grellier Fleming White Rojas-Rueda Tags: Article Source Type: research

Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy
Neurobiol Dis. 2021 Mar 25:105339. doi: 10.1016/j.nbd.2021.105339. Online ahead of print.ABSTRACTMoyamoya-like vasculopathy, the "puff of smoke"-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a rare cerebrovascular disease, and later found in patients with various types of neurological conditions, including Down syndrome, Stroke, and vascular dementia. It is thus of interest to understand how this vasculopathy is developed. Here, we provided evidence for cortical astrocytic neogenin (NEO1) deficiency to be a risk factor for its development. NEO1, a member of deleted in col...
Source: Neurobiology of Disease - March 29, 2021 Category: Neurology Authors: Xiao Ren Ling-Ling Yao Jin-Xiu Pan Jun-Shi Zhang Lin Mei Yong-Gang Wang Wen-Cheng Xiong Source Type: research

Physical inactivity and non-communicable disease burden in low-income, middle-income and high-income countries
CONCLUSION: The global burden associated with physical inactivity is substantial. The relative burden is greatest in high-income countries; however, the greatest number of people (absolute burden) affected by physical inactivity are living in middle-income countries given the size of their populations.PMID:33782046 | DOI:10.1136/bjsports-2020-103640
Source: British Journal of Sports Medicine - March 30, 2021 Category: Sports Medicine Authors: Peter T Katzmarzyk Christine Friedenreich Eric J Shiroma I-Min Lee Source Type: research

Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy
Neurobiol Dis. 2021 Mar 25:105339. doi: 10.1016/j.nbd.2021.105339. Online ahead of print.ABSTRACTMoyamoya-like vasculopathy, the "puff of smoke"-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a rare cerebrovascular disease, and later found in patients with various types of neurological conditions, including Down syndrome, Stroke, and vascular dementia. It is thus of interest to understand how this vasculopathy is developed. Here, we provided evidence for cortical astrocytic neogenin (NEO1) deficiency to be a risk factor for its development. NEO1, a member of deleted in col...
Source: Neurobiology of Disease - March 29, 2021 Category: Neurology Authors: Xiao Ren Ling-Ling Yao Jin-Xiu Pan Jun-Shi Zhang Lin Mei Yong-Gang Wang Wen-Cheng Xiong Source Type: research

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