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Condition: Dementia
Management: Hospitals

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Total 122 results found since Jan 2013.

Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy
Am J Trop Med Hyg. 2021 Jul 19:tpmd200401. doi: 10.4269/ajtmh.20-0401. Online ahead of print.ABSTRACTChagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and dementia. In the present study, we selected five candidate biomarkers for Chagas disease: interleukin-6, membrane metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP1), oros...
Source: The American Journal of Tropical Medicine and Hygiene - July 19, 2021 Category: Tropical Medicine Authors: Karina Oliveira Garcia Thiago Cerqueira Silva Maria do Carmo Pereira Nunes Iuri Ferreira Felix Murilo Araujo Oliveira Maria Eduarda Lisboa Marques Leila Souza Brito Santos Paulo Roberto Sampaio Peixoto Sousa Pedro Jos é Ramiro Muiños Renata Martins Maia Source Type: research

A third of dying patients do not have end-of-life discussions with a physician: A nationwide registry study
Palliat Support Care. 2021 Jun 23:1-6. doi: 10.1017/S1478951521000973. Online ahead of print.ABSTRACTOBJECTIVE: The aim of the study was to explore the proportion of adult patients and next-of-kin who had end-of-life (EOL) discussions and associated factors.METHOD: A retrospective nationwide registry study was reported with data from the Swedish Register of Palliative Care. All patients in Sweden in hospitals, nursing homes, own homes, community, and palliative care units during 2015-2017 and their next-of-kin were included. Data were reported to the register by healthcare staff, based on diseased patients' records regardi...
Source: Palliative and Supportive Care - June 23, 2021 Category: Palliative Care Authors: Christina Melin-Johansson Josefin Sveen Malin L övgren Camilla Udo Source Type: research

Stem cell therapy promotes recovery from stroke and dementia in mice
A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia,a new UCLA study finds.Dementia can arise from multiple conditions, and it is characterized by an array of symptoms including problems with memory, attention, communication and physical coordination. The two most common causes of dementia are Alzheimer ’s disease and white matter strokes — small strokes that accumulate in the connecting areas of the brain.“It’s a vicious cycle: The two leading causes of dementia are almost always seen togeth...
Source: UCLA Newsroom: Health Sciences - April 22, 2021 Category: Universities & Medical Training Source Type: news

Disability-free survival after major cardiac surgery: a population-based retrospective cohort study
CMAJ Open. 2021 Apr 16;9(2):E384-E393. doi: 10.9778/cmajo.20200096. Print 2021 Apr-Jun.ABSTRACTBACKGROUND: Cardiovascular research has traditionally been dedicated to "tombstone" outcomes, with little attention dedicated to the patient's perspective. We evaluated disability-free survival as a patient-defined outcome after cardiac surgery.METHODS: We conducted a retrospective cohort study of patients aged 40 years and older who underwent coronary artery bypass grafting (CABG) or single or multiple valve (aortic, mitral, tricuspid) surgery in Ontario between Oct. 1, 2008, and Dec. 31, 2016. The primary outcome was disability...
Source: cmaj - April 17, 2021 Category: General Medicine Authors: Louise Y Sun Anan Bader Eddeen Thierry G Mesana Source Type: research

IJERPH, Vol. 18, Pages 3673: Mild to Severe Neurological Manifestations of COVID-19: Cases Reports
Alberto Barbieri The main focus of Coronavirus disease 2019 (COVID-19) infection is pulmonary complications through virus-related neurological manifestations, ranging from mild to severe, such as encephalitis, cerebral thrombosis, neurocognitive (dementia-like) syndrome, and delirium. The hospital screening procedures for quickly recognizing neurological manifestations of COVID-19 are often complicated by other coexisting symptoms and can be obscured by the deep sedation procedures required for critically ill patients. Here, we present two different case-reports of COVID-19 patients, describing neurological complica...
Source: International Journal of Environmental Research and Public Health - April 1, 2021 Category: Environmental Health Authors: Gabriele Melegari Veronica Rivi Gabriele Zelent Vincenzo Nasillo Elena De Santis Alessandra Melegari Claudia Bevilacqua Michele Zoli Stefano Meletti Alberto Barbieri Tags: Case Report Source Type: research

Clinical and radiological aspects of bilateral temporal abnormalities: pictorial essay
Abstract The temporal lobes are vulnerable to several diseases, including infectious, immune-mediated, degenerative, vascular, metabolic, and neoplastic processes. Therefore, lesions in the temporal lobes can pose a diagnostic challenge for the radiologist. The temporal lobes are connected by structures such as the anterior commissure, corpus callosum, and hippocampal commissure. That interconnectedness favors bilateral involvement in various clinical contexts. This pictorial essay is based on a retrospective analysis of case files from a tertiary university hospital and aims to illustrate some of the conditions that simul...
Source: Radiologia Brasileira - March 26, 2021 Category: Radiology Source Type: research

Effect of acupuncture treatment on post-stroke cognitive impairment: A randomized controlled trial
Introduction: Post-stroke cognitive impairment (PSCI), which has a high morbidity, is closely associated with the recurrence and rehabilitation of ischemic stroke. There are 2 different stages of PSCI, including post-stroke cognitive impairment with no dementia (PSCIND) and post-stroke dementia (PSD). The latter has a significantly higher mortality rate than the previous one. Therefore, preventing the onset of PSD is of vital importance. However, there is no unequivocally effective prevention or treatment for PSCI, except intensive secondary prevention of stroke. The primary aim of this protocol is to explore whether a...
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Undertriage Despite Use of Geriatric-Specific Trauma Team Activation Guidelines : Who Are We Missing?
The objective of this study was to determine whether implementation of geriatric-specific trauma team activation (TTA) protocols appropriately identified severely-injured elderly patients. METHODS: This single-center retrospective study evaluated all severely injured (injury severity score [ISS] >15), geriatric (≥65 years) patients admitted to our Level 1 tertiary-care hospital between January 2014 and September 2017. Undertriage was defined as the lack of TTA despite presence of severe injuries. The primary outcome was all-cause in-hospital mortality; secondary outcomes were mortality within 48 hours of admissio...
Source: The American Surgeon - October 7, 2020 Category: Surgery Authors: Anantha RV, Painter MD, Diaz-Garelli F, Nunn AM, Miller PR, Chang MC, Jason Hoth J Tags: Am Surg Source Type: research

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Authors: Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P Abstract We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, o...
Source: The Journal of Alzheimers Association - August 14, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation –Liaison Service
AbstractPurpose of ReviewTo provide consultation –liaison psychiatrists with an updated resource that can assist in the treatment and management of geriatric patients.Recent FindingsThe current available literature has not shown any differences in efficacy between haloperidol and second-generation antipsychotics in patients with delirium. When considering relative advantages of forms of antipsychotic administration, there is no support for a superior safety profile of oral compared to intramuscular or intravenous administration. A recent meta-analysis of four randomized controlled trials concluded that when melatonin was...
Source: Current Psychiatry Reports - April 12, 2020 Category: Psychiatry Source Type: research

Acetylcholinesterase inhibitors are associated with reduced fracture risk among older Veterans with dementia
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - November 10, 2019 Category: Orthopaedics Authors: Abayomi N. Ogunwale, Cathleen S. Colon ‐Emeric, Richard Sloane, Robert A. Adler, Kenneth W. Lyles, Richard H. Lee Tags: Original Article Source Type: research