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Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

What It ’s Like Living With Aphasia—and How to Support a Loved One With the Condition
Bruce Willis, the 67-year-old actor and star of classic action movies like Die Hard, is halting his acting career after being diagnosed with the language disorder aphasia. On March 30, his daughter Rumer, ex-wife Demi Moore, and other family members announced the diagnosis on Instagram. “Our beloved Bruce has been experiencing some health issues and has recently been diagnosed with aphasia, which is impacting his cognitive abilities,” the family wrote. “As a result of this and with much consideration Bruce is stepping away from the career that has meant so much to him.” [time-brightcove not-tgx=R...
Source: TIME: Health - March 31, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized healthscienceclimate medicine Source Type: news

High Proportion of Deceased Football Players Found to Have CTE
A postmortem analysis of the brains of 202 former football players from the high-school to the professional level has revealed that 87% of these athletes had neuropathological signs of chronic traumatic encephalopathy (CTE) —a progressive neurodegenerative disorder associated with repetitive head trauma. Moreover, as reported today inJAMA, all but one of the brains of the former National Football League (NFL) players showed neuropathological signs of the disease.“Nearly all of the former NFL players in this study had CTE pathology, and this pathology was frequently severe,” wrote senior author Ann McKee, M.D., of the...
Source: Psychiatr News - July 25, 2017 Category: Psychiatry Tags: Ann McKee chronic traumatic encephalopathy CTE football neurodegeneration NFL Source Type: research

Snoring link to Alzheimer ’s disease unproven
Conclusion This relatively large cross-sectional analysis has found a link between certain measures of breathing problems during sleep and poorer cognitive function in middle-aged to older adults. The strengths of this study include its size and use of a prospective sleep study to assess whether people had sleep apnoea or other problems with breathing during sleep. The use of standard cognitive tests is also a strength. However, the study does have its limitations: The study did have mixed findings – while certain measures of problems with breathing during sleep (e.g. oxygen levels) were associated with cognitive outco...
Source: NHS News Feed - July 24, 2017 Category: Consumer Health News Tags: Neurology Lifestyle/exercise Source Type: news

Reported link between diet drinks and dementia and stroke is weak
Conclusion The researchers used data from a large ongoing cohort study to look for links between consumption of sugary and artificially sweetened drinks and risk of stroke or dementia. This cohort study benefits from the large overall sample size, long period of data collection, careful and valid diagnostic assessments, and adjustments for a number of confounders. However, care must be taken when interpreting these results – particularly if latching on to the maximal tripled risk figures reported in the media. There are several points to consider: Small numbers The new number of strokes and dementia in this study was sma...
Source: NHS News Feed - April 21, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Neurology Source Type: news

Study: Drinking Diet Soda Could Increase Risk Of Dementia, Stroke
BOSTON (CBS) – Diet soda has long been touted as a healthier alternative to sugary soft drinks, but a new study raises some concerning questions. According to new research published in the American Heart Association’s journal Stroke, consuming one or more artificially sweetened drinks per day may be linked to a higher risk of stroke and dementia. Those who drank one or more artificially sweetened drinks daily had a 2.89 times higher risk of dementia, and 2.96 higher risk of stroke than people who had less than one of those drinks per week. The people studied are participating in the Framingham Heart Study, which is A...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 21, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Uncategorized Diet Soda Study Source Type: news

Diet drinks TRIPLE your risk of stroke and dementia
The Boston University study of almost 4,400 adults suggests diet drinks are more likely to cause strokes and dementia than those full of sugar.
Source: the Mail online | Health - April 20, 2017 Category: Consumer Health News Source Type: news

Is soda bad for your brain? (and is diet soda worse?)
(Boston University) New research suggests that excess sugar -- especially the fructose in sugary drinks -- might damage your brain. Researchers at Boston University found that people who drink sugary beverages frequently are more likely to have poorer memory, smaller overall brain volume, and a significantly smaller hippocampus. A follow-up study found that people who drank diet soda daily were almost three times as likely to develop stroke and dementia when compared to those who did not.
Source: EurekAlert! - Medicine and Health - April 20, 2017 Category: Global & Universal Source Type: news

Blood Pressure Trajectories from Mid to Late Life and Risk of Dementia: The Framingham Study (S49.003)
Conclusions:Elevated blood pressure in mid-life, persistent hypertension into late-life and, among non-hypertensives, a steep decline in blood pressure from mid-to-late life were each associated with an elevated risk of dementia in a community-based sample. Our data highlight the potential sustained cognitive benefits of lower midlife blood pressures and raise the possibility that lowering of blood pressure in older adults with borderline hypertension may be harmful to cognition, despite a beneficial impact on cardiovascular events.Study Supported by:Framingham Heart Study, (NHLBI/NIH contract HHSN268201500001I) to the Bos...
Source: Neurology - April 17, 2017 Category: Neurology Authors: McGrath, E., Beiser, A., DeCarli, C., Plourde, K., Ramachandran, V., Greenberg, S., Seshadri, S. Tags: Best Of: Aging and Dementia Source Type: research

Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03, Bos...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

Exercise results in larger brain size and lowered dementia risk
FINDINGS Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals. This suggests that regular physical activity for older adults could lead to higher brain volumes and a reduced risk for developing dementia. The researchers found that physical activity particularly affected the size of the hippocampus, which is the part of the brain controlling short-term memory. Also, the protective effect of regular physical activit...
Source: UCLA Newsroom: Health Sciences - August 2, 2016 Category: Universities & Medical Training Source Type: news

Social Relationships, Serum Brain-Derived Neurotrophic Factor, and the Risk for Stroke and Dementia: The Framingham Heart Study (P1.098)
Conclusions: In our large community sample, greater social support was associated with increased BDNF levels and, in certain dimensions of support, reduced risk of subsequent dementia and stroke. Further study of the biological and social mechanisms through which support from social networks reduce these risks is needed to determine whether relatively simple social interventions may help protect against age-related neurologic disease. Study Supported by: Boston University School of Medicine, a contract from NHLBI (N01-HC 25195), and by grants from the NINDS (NS017950) and NIA (AG031287, AG008122, AG033193).Disclosure: Dr. ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Salinas, J. Tags: Epidemiology of Aging and Dementias Source Type: research

Framingham Study Suggests Dementia Rates May Be Falling
Many experts predict that as people live longer, the prevalence of dementia will climb. However, a study published in the New England Journal of Medicine now suggests the incidence of dementia may be falling.Researchers from Boston University School Medicine analyzed data from 5,205 people aged 60 and older who were participants in the Framingham Heart Study, a community-based, longitudinal cohort study that was initiated in 1948. Since 1975, the cognitive status of the original cohort has been regularly monitored via the Mini-Mental State Examination, neurological and neuropsychological examinations, and subjective memory...
Source: Psychiatr News - February 18, 2016 Category: Psychiatry Tags: dementia Framingham Heart Study stroke risk Source Type: research

People with gout have lower risk of Alzheimer’s disease
Conclusion This population-based study has found that people with gout had a 24% reduced risk of developing Alzheimer’s disease. It was a well-designed study, in that there were large numbers of people in each group and multiple potential confounding factors were taken into account. The validation of the study was also valuable in showing the expected lack of a link between osteoarthritis and Alzheimer’s disease. However, there are some limitations with this type of study, with a major one being that it cannot prove cause and effect. While some potential confounding factors were accounted for in the statistical analysi...
Source: NHS News Feed - March 5, 2015 Category: Consumer Health News Tags: Medical practice Neurology Older people Source Type: news