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Specialty: General Medicine
Condition: Pulmonary Hypertension

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Total 17 results found since Jan 2013.

Trends in cardiovascular complications of pregnancy: A nationwide inpatient sample analysis
CONCLUSION: There are concerning increases in certain cardiac complications during pregnancy. This is likely due to increasing age at the time of pregnancy and associated comorbidities.PMID:37678669 | DOI:10.1016/j.amjms.2023.09.001
Source: The American Journal of the Medical Sciences - September 7, 2023 Category: General Medicine Authors: Eric D Warner Saaniya Farhan Matthew Bierowski Farhan Sahawneh Estefania Oliveros Preethi Pirlamarla Stefanie Marek-Iannucci Bhavadharini Ramu Waqas Ullah Yevgeniy Brailovsky Indranee N Rajapreyar Source Type: research

Trends in cardiovascular complications of pregnancy: A Nationwide Inpatient Sample analysis: Trends in cardiovascular complications of pregnancy
CONCLUSION: There are concerning increases in certain cardiac complications during pregnancy. This is likely due to increasing age at the time of pregnancy and associated comorbidities.PMID:37678669 | DOI:10.1016/j.amjms.2023.09.001
Source: The American Journal of the Medical Sciences - September 7, 2023 Category: General Medicine Authors: Eric D Warner Saaniya Farhan Matthew Bierowski Farhan Sahawneh Estefania Oliveros Preethi Pirlamarla Stefanie Marek-Iannucci Bhavadharini Ramu Waqas Ullah Yevgeniy Brailovsky Indranee N Rajapreyar Source Type: research

HIV, Subclinical Cardiovascular Disease, and Clinical Progression
People living with HIV have higher risks of cardiovascular disease (CVD) including myocardial infarction, heart failure, stroke, pulmonary hypertension, and sudden cardiac death than those without HIV. These excess CVD risks persist in the modern HIV treatment era and are not readily explained by demographic, environmental, or clinical confounding factors. Nor are these HIV-associated CVD risks explained by antiretroviral therapy (ART); the net cardiovascular and overall benefits of effective HIV treatment clearly outweigh the risks. Thus, refining HIV-specific contributors to CVD pathogenesis is critically important for i...
Source: JAMA - September 13, 2022 Category: General Medicine Source Type: research

Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
CONCLUSIONS: HIF stabiliser management of anaemia had uncertain effects on CV death, fatigue, death (any cause), CV outcomes, and kidney failure compared to placebo or ESAs. Compared to placebo or ESAs, HIF stabiliser management of anaemia probably decreased the proportion of patients requiring blood transfusions, and probably increased the proportion of patients reaching the target Hb when compared to placebo.PMID:36005278 | DOI:10.1002/14651858.CD013751.pub2
Source: Cochrane Database of Systematic Reviews - August 25, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Allison Jaure Elisabeth M Hodson Marinella Ruospo Tess E Cooper Deirdre Hahn Valeria M Saglimbene Jonathan C Craig Giovanni Fm Strippoli Source Type: research

Sickle Cell Trait and Risks for Common Diseases: Evidence from the UK Biobank
Sickle cell disease is an autosomal recessive disease caused by the inheritance of two pathogenic mutations of the hemoglobin subunit beta gene (HBB) (usually Glu6Val, though other pathogenic mutations exist).1 The altered hemoglobin makes red blood cells prone to being crescent-shaped, which can cause vaso-occlusion and result in numerous serious complications and comorbidities including: vaso-occlusive crisis, acute chest syndrome, infections, pulmonary hypertension, stroke, pulmonary embolism, renal failure, retinopathy, splenic sequestration, priapism, cholelithiasis, and osteonecrosis.
Source: The American Journal of Medicine - April 21, 2022 Category: General Medicine Authors: Joseph Hulsizer, W. Kyle Resurreccion, Zhuqing Shi, Jun Wei, Skylar Ladson-Gary, S. Lilly Zheng, Brian T. Helfand, Liana Billings, Michael S. Caplan, Jianfeng Xu Source Type: research

Thrombolytic therapy for pulmonary embolism
CONCLUSIONS: Low-certainty evidence suggests that thrombolytics may reduce death following acute pulmonary embolism compared with heparin (the effectiveness was mainly driven by one trial with massive PE). Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause more major and minor haemorrhagic events, including haemorrhagic stroke. More studies of high methodological quality are needed to assess safety and cost effectiveness of thrombolytic therapy for people with pulmonary embolism.PMID:33857326 | DOI:10.1002/14651858.CD004437.pub6
Source: Cochrane Database of Systematic Reviews - April 15, 2021 Category: General Medicine Authors: Zhiliang Zuo Jirong Yue Bi Rong Dong Taixiang Wu Guan J Liu Qiukui Hao Source Type: research

ECMO in Neonates with Congenital Diaphragmatic Hernia: The Experience of a Portuguese ECMO Referral Center.
CONCLUSION: Survival rate was higher than reported in 2017 Extracorporeal Life Support Organization report (64% versus 50%). Mechanical and hemorrhagic complications were very frequent. PMID: 33496251 [PubMed - in process]
Source: Acta Medica Portuguesa - January 28, 2021 Category: General Medicine Tags: Acta Med Port Source Type: research

Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults.
CONCLUSIONS: This review identified only nine studies, with insufficient data for all pharmacological interventions for analysis. The available evidence is very uncertain regarding the efficacy or harm from pharmacological interventions used to treat pain related to sickle cell VOC in adults. This area could benefit most from more high quality, certain evidence, as well as the establishment of suitable registries which record interventions and outcomes for this group of people. PMID: 31742673 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 13, 2019 Category: General Medicine Authors: Cooper TE, Hambleton IR, Ballas SK, Johnston BA, Wiffen PJ Tags: Cochrane Database Syst Rev Source Type: research

Thrombolytic therapy for pulmonary embolism.
CONCLUSIONS: Low-quality evidence suggests that thrombolytics reduce death following acute pulmonary embolism compared with heparin. The included studies used a variety of thrombolytic drugs. Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause major and minor haemorrhagic events and stroke. More high-quality, blinded randomised controlled trials assessing safety and cost-effectiveness of therapies for pulmonary embolism are required. PMID: 30560579 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 18, 2018 Category: General Medicine Authors: Hao Q, Dong BR, Yue J, Wu T, Liu GJ Tags: Cochrane Database Syst Rev Source Type: research

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.
Authors: Mustafa ER, Tudoraşcu DR, Giucă A, Toader DM, Foarfă MC, Puiu I, Istrate-Ofiţeru AM Abstract A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosi...
Source: Romanian Journal of Morphology and Embryology - December 13, 2018 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Initial experience with percutaneous edge-to-edge transcatheter mitral valve repair in a tertiary medical center in Taiwan
Conclusion Trans-catheter edge-to-edge mitral valve repairs are safe and effective in Asians with symptomatic SMR, regarding the improvements of clinical symptoms and exercise capacities. MitraClips is also associated with reverse remodeling of pulmonary hypertension and left ventricular size in patients with SMR.
Source: Journal of the Chinese Medical Association - December 29, 2017 Category: General Medicine Source Type: research

Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A  case report.
CONCLUSION: Intermittent low-dose therapy with bevacizumab represents an effective and cost-efficient treatment option for transfusion-dependent patients with hereditary hemorrhagic telangiectasia. PMID: 27878613 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - November 22, 2016 Category: Journals (General) Authors: Huemer F, Dejaco M, Grabmer C, Melchardt T, Neureiter D, Mayer G, Egle A, Greil R, Weiss L Tags: Wien Klin Wochenschr Source Type: research

Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction : Study protocol for a  randomized controlled trial.
Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction : Study protocol for a randomized controlled trial. Wien Klin Wochenschr. 2016 Sep 2; Authors: Mascherbauer J, Grünig E, Halank M, Hohenforst-Schmidt W, Kammerlander AA, Pretsch I, Steringer-Mascherbauer R, Ulrich S, Lang IM, Wargenau M, Frey R, Bonderman D Abstract BACKGROUND: The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFPEF) resulting in substantial morbidity and ...
Source: Wiener Klinische Wochenschrift - September 1, 2016 Category: Journals (General) Authors: Mascherbauer J, Grünig E, Halank M, Hohenforst-Schmidt W, Kammerlander AA, Pretsch I, Steringer-Mascherbauer R, Ulrich S, Lang IM, Wargenau M, Frey R, Bonderman D Tags: Wien Klin Wochenschr Source Type: research

Effects of obstructive sleep apnoea risk on postoperative respiratory complications: protocol for a hospital-based registry study
Introduction Obstructive sleep apnoea (OSA), the most common type of sleep-disordered breathing, is associated with significant immediate and long-term morbidity, including fragmented sleep and impaired daytime functioning, as well as more severe consequences, such as hypertension, impaired cognitive function and reduced quality of life. Perioperatively, OSA occurs frequently as a consequence of pre-existing vulnerability, surgery and drug effects. The impact of OSA on postoperative respiratory complications (PRCs) needs to be better characterised. As OSA is associated with significant comorbidities, such as obesity, pulmo...
Source: BMJ Open - January 13, 2016 Category: Journals (General) Authors: Shin, C. H., Zaremba, S., Devine, S., Nikolov, M., Kurth, T., Eikermann, M. Tags: Open access, Anaesthesia, Epidemiology, Pharmacology and therapeutics, Respiratory medicine, Surgery Protocol Source Type: research