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Condition: Thrombocytopenia

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Total 366 results found since Jan 2013.

Current status of drug repositioning in hematology
Expert Rev Hematol. 2021 Oct 16. doi: 10.1080/17474086.2021.1995348. Online ahead of print.ABSTRACTINTRODUCTION: Drug repositioning (DR) is defined as determining new therapeutic applications for existing drugs. This approach is advantageous over de novo drug discovery in accelerating clinical development, in terms of lower costs, a shortened development period, a well-known action mechanism, a feasible dosage, and an acceptable safety profile.AREAS COVERED: This work was aimed at reviewing agents with successful DR in hematology.EXPERT OPINION: Thalidomide and plerixafor have been successfully repositioned for treating mu...
Source: Expert Review of Hematology - October 18, 2021 Category: Hematology Authors: Akihiro Ohmoto Shigeo Fuji Source Type: research

A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
We report an atypical manifestation of immune-mediated thrombotic thrombocytopenic purpura (TTP) that we hypothesize represents a longstanding, or “smoldering,” process. As typified by this case, the prompt recognition and treatment for immune-mediated TTP are often confounded by clinical comorbidities. Thus, TTP should be considered in cases of unremitting thrombocytopenia of unknown origin in patients with stroke or other thrombosis. AbstractPrompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic ...
Source: Clinical Case Reports - October 12, 2021 Category: General Medicine Authors: Mark E. Pepin, Eyad Saca, Soo Y. Kwon, Jori May Tags: CASE REPORT Source Type: research

Cervicocerebral atherosclerosis and its hepatic and coronary risk factors in patients with liver cirrhosis
CONCLUSIONS: Our data suggest that LC confers protection against intracranial atherosclerosis, and that thrombocytopenia may be involved in this protection. High CAC score could serve as a potential surrogate for cervicocerebral vascular screening in asymptomatic cirrhotics.PMID:34637612 | DOI:10.3350/cmh.2021.0202
Source: Clinical and molecular hepatology - October 12, 2021 Category: Gastroenterology Authors: Jihyun An Hyung Don Kim Seon-Ok Kim Ha Il Kim Gi-Won Song Han Chu Lee Ju Hyun Shim Source Type: research

Thrombotic Thrombocytopenic Purpura Without Schistocytes: Beware of Misdiagnosis
A 43-year-old woman was admitted for acute unusual headache, vertigo, and left upper limb weakness. She had been complaining of asthenia for the past few weeks. Her medical history included uterine cervix cancer treated with conisation and 2 pregnancies without serious complications. No allergy or recent drug introduction was noted. After ruling out current pregnancy, magnetic resonance imaging (MRI) was immediately performed and showed recent ischemic strokes in multiple territories. Doppler ultrasound imaging showed no carotid or vertebral arteries lesion. Electrocardiogram showed no ST elevation or atrial fibrillation, ...
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Decker, P., Moulinet, T., Revuz, S., Perez, P., Jaussaud, R. Tags: Autoimmune diseases, Hematologic, All Cerebrovascular disease/Stroke Case Source Type: research

Vaccine-Induced Immune Thrombotic Thrombocytopenia with Concurrent Arterial and Venous Thrombi Following Ad26.COV2.S Vaccination
We describe a case of simultaneous venous and arterial thrombosis associated with severe thrombocytopenia following Ad26.COV2.S vaccination.
Source: Journal of Stroke and Cerebrovascular Diseases - September 18, 2021 Category: Neurology Authors: Andreas Charidimou, Shilpa Samudrala, Anna M. Cervantes-Arslanian, J. Mark Sloan, Hormuzdiyar H. Dasenbrock, Ali Daneshmand Tags: Case Report Source Type: research

Neuro ‐COVID‐19
AbstractNeuromuscular manifestations of new coronavirus infection (COVID-19) are frequent and include dizziness, headache, myopathy, and olfactory and gustatory disturbances. Patients with acute central nervous system (CNS) disorders, such as delirium, impaired consciousness, stroke, and convulsive seizures, have a high mortality rate. The encephalitis/encephalopathy that causes consciousness disturbance and seizures can be classified into three conditions, including direct infection with the SARS-CoV-2 virus, encephalopathy caused by CNS damage secondary to systemic hypercytokinemia (cytokine storm), and autoimmune-mediat...
Source: Clinical and Experimental Neuroimmunology - September 12, 2021 Category: Neurology Authors: Takayoshi Shimohata Tags: REVIEW ARTICLE Source Type: research

Treatment of ChAdOx1 nCoV-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia Related Acute Ischemic Stroke
We report clinical, laboratory, imaging findings and treatment in a 51-year-old female presenting with acute left middle cerebral artery (MCA) occlusion 7 days after the first dose of ChAdOx1 nCoV-19 vaccine.
Source: Journal of Stroke and Cerebrovascular Diseases - August 28, 2021 Category: Neurology Authors: Jana Kenda, Dimitrij Lovri č, Matevž Škerget, Nataša Milivojević Tags: Short Communication Source Type: research

A case series analysis on the clinical experience of Impella 5.5 ® at a large tertiary care centre
ConclusionsIn this early experience of the pVAD 5.5, procedural and device-related complications were observed but were manageable, and overall survival was high in this critically ill cohort, particularly when the device was used as a bridge to other therapies.
Source: ESC Heart Failure - August 17, 2021 Category: Cardiology Authors: Peter J. Kennel, Heidi Lumish, Yuji Kaku, Justin Fried, Ajay J. Kirtane, Dimitri Karmpaliotis, Hiroo Takayama, Yoshifumi Naka, Gabriel Sayer, Nir Uriel, Koji Takeda, Amirali Masoumi Tags: Original Research Article Source Type: research

Hemorrhagic stroke associated to COVID-19 infection in Mexico General Hospital
CONCLUSIONES: la HC se asocia a la infección por SARS-CoV-2 con mal pronóstico cuando se presenta. Los equipos de neurocirugía deben estar preparados para el tratamiento oportuno de estos pacientes.INTRODUCTION: In the current COVID-19 pandemic, there is a growing body of evidence that has identified the neurotropism of the SARS-CoV-2 virus and its neurological complications, including cerebrovascular disease, focusing mainly in ischemic and scarcely about hemorrhagic stroke (HS).OBJECTIVE: The objective of the study was to describe clinical, radiological, laboratory tests, and prognostic characteristics of patients wit...
Source: Cirugia y Cirujanos - August 5, 2021 Category: Surgery Authors: Gustavo Parra-Romero Ariatne Mar- Álvarez Jos é L Navarro-Olvera Aldo F Hern ández-Valencia Gustavo Aguado-Carrillo Jos é D Carrillo-Ruiz Source Type: research