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Association between obstructive sleep apnea and cardiovascular diseases
Acta Biochim Biophys Sin (Shanghai). 2022 Jul 25. doi: 10.3724/abbs.2022084. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is a common respiratory disorder characterized by partial obstruction of upper respiratory tract and repetitive cessation of breathing during sleep. The etiology behind OSA is associated with the occurrence of intermittent hypoxemia, recurrent arousals and intrathoracic pressure swings. These contributing factors may turn on various signaling mechanisms including elevated sympathetic tone, oxidative stress, inflammation, endothelial dysfunction, cardiovascular variability, abnormal coagul...
Source: Acta Biochimica et Biophysica Sinica - July 15, 2022 Category: Biochemistry Authors: Yiran E Li Jun Ren Source Type: research

Heart health in polycystic ovary syndrome: time to act on the data
Fertil Steril. 2022 May;117(5):885-886. doi: 10.1016/j.fertnstert.2022.03.014.ABSTRACTPolycystic ovary syndrome (PCOS), first described over 80 years ago, is a chronic condition with gynecologic, metabolic, and psychologic manifestations. Both hyperandrogenism and insulin resistance are associated with the high prevalence of cardiometabolic risk factors described in this population. Although robust data in reproductive-age women demonstrate a high rate of obesity, impaired glucose tolerance, hypertension, dyslipidemia, and metabolic syndrome, studies show mixed results in the adolescent and menopausal age groups. There is ...
Source: Atherosclerosis - May 5, 2022 Category: Cardiology Authors: Anuja Dokras Source Type: research

Cardiovascular Outcomes in Sleep-Disordered Breathing: Are We Under-estimating?
Obstructive sleep apnea is a growing health concern, affecting nearly one billion people worldwide; increasingly recognized as an independent cardiovascular risk factor associated with incident obesity, insulin resistance, hypertension, arrhythmias, stroke, coronary artery disease, and heart failure. The prevalence of obstructive sleep apnea could be underestimated in the previous studies, leading to only modest predictions of cardiovascular outcomes. Using more physiologic data will increase sensitivity for the diagnosis of obstructive sleep apnea. Individuals at high risk of obstructive sleep apnea should be identified s...
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research

The dream of a good night's sleep for our dermatology patients
Are you getting adequate sleep? Chances are that you are not and the repercussions could be profound. Sleep deprivation has been associated with insulin resistance, diabetes mellitus, obesity, hypertension, obstructive sleep apnea, anxiety and depression, and an increased risk of myocardial infarction and stroke. Quality of life (QoL) may suffer by poor job performance, an increased risk of accidents, and family stress.1
Source: Journal of the American Academy of Dermatology - August 2, 2021 Category: Dermatology Authors: Warren R. Heymann Tags: A clinician's perspective Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Using wearable devices in clinical trials
Brandy Chittester, chief of clinical operations, IMARC Globally, more than 325 million people own wearable, connected devices, and more than 2.5 billion own smartphones. Using wearable devices in clinical trials can bring huge benefits, however, there are also concerns. Here’s a look at how researchers are using wearable devices — and what you should consider before using them in your own research. How wearable devices are advancing medicine Right now, ClinicalTrials.gov, a global database of clinical trials, lists nearly 200 trials with “wearable devices” or “wearable technology” in the description. This in...
Source: Mass Device - March 12, 2019 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog IMARC Source Type: news

Bariatric surgery and diabetes remission: how far have we progressed?
This article will review the effectiveness of bariatric procedures on the remission and improvement of diabetes and its implicated mechanisms. PMID: 30298760 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - October 12, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Guess What Google ’s Verily is Up to Now
Verily Life Sciences has formed yet another joint venture with a medtech company. This time Verily, once known as Google’s life sciences division, is teaming up with sleep-health specialist ResMed to tackle sleep apnea. The collaboration with ResMed expands the Mountain View, CA-based company’s presence into yet another healthcare segment. ResMed executives declined to discuss specific details about the joint venture, noting it was still subject to regulatory approvals. However, ResMed CMO Carlos Nunez said the joint venture will operate as a completely separate entity from ResMed and Verily. Nunez noted ResMed had ext...
Source: MDDI - July 11, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Digital Health Source Type: news

Guess What Alphabet ’s Verily is Up to Now
Verily Life Sciences has formed yet another joint venture with a medtech company. This time Verily, once known as Google’s life sciences division, is teaming up with sleep-health specialist ResMed to tackle sleep apnea. The collaboration with ResMed expands the Mountain View, CA-based company’s presence into yet another healthcare segment. ResMed executives declined to discuss specific details about the joint venture, noting it was still subject to regulatory approvals. However, ResMed CMO Carlos Nunez said the joint venture will operate as a completely separate entity from ResMed and Verily. Nunez noted ResMed had ext...
Source: MDDI - July 11, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Digital Health Source Type: news

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