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Condition: Fatty Liver Disease (FLD)

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Total 312 results found since Jan 2013.

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Reply Effects of Habitual Coffee Consumption on Vascular Function
We thank Dr. Siasos and colleagues for pointing out that habitual coffee consumption has been associated with improved endothelial function in elderly inhabitants of Ikaria Island (1). The improvement in endothelial function may in part account for the associations of moderate coffee intake (about 2 to 4 cups daily) with lower risks for coronary heart disease and stroke (2). Indeed, even in the setting of endothelium damage, coffee has the ability to prevent arterial thrombus formation, a benefit that is independent of its caffeine content (3). Recent studies also indicate that moderate daily coffee intake may confer pro...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - February 10, 2014 Category: Cardiology Source Type: research

Reply: Effects of Habitual Coffee Consumption on Vascular Function
We thank Dr. Siasos and colleagues for pointing out that habitual coffee consumption has been associated with improved endothelial function in elderly inhabitants of Ikaria Island . The improvement in endothelial function may in part account for the associations of moderate coffee intake (about 2 to 4 cups daily) with lower risks for coronary heart disease and stroke . Indeed, even in the setting of endothelium damage, coffee has the ability to prevent arterial thrombus formation, a benefit that is independent of its caffeine content . Recent studies also indicate that moderate daily coffee intake may confer protection a...
Source: Journal of the American College of Cardiology - November 1, 2013 Category: Cardiology Authors: James J. DiNicolantonio, James H. O'Keefe, Carl J. Lavie Tags: Letters to the Editor Source Type: research

Molecular signatures for obesity and associated disorders identified through partial least square regression models
Conclusion: We identified the early gene-expression signature for the onset of obesity and type 2 diabetes. Further analysis of this data suggests that some of these genes could be used as potential biomarkers for these two disease-states.
Source: BMC Systems Biology - Latest articles - August 30, 2014 Category: Molecular Biology Authors: Neeraj SinhaSachin SharmaParul TripathiSimarjeet NegiKamiya TikooDhiraj KumarKanury RaoSamrat Chatterjee Source Type: research

Neurocritical care complications of pregnancy and puerperum
Abstract: Neurocritical care complications of pregnancy and puerperum such as preeclampsia/eclampsia, hemolysis, elevated liver enzymes, low platelets syndrome, thrombotic thrombocytopenic purpura, seizures, ischemic and hemorrhagic stroke, postpartum angiopathy, cerebral sinus thrombosis, amniotic fluid emboli, choriocarcinoma, and acute fatty liver of pregnancy are rare but can be devastating. These conditions can present a challenge to physicians because pregnancy is a unique physiologic state, most therapeutic options available in the intensive care unit were not studied in pregnant patients, and in many situations, ph...
Source: Journal of Critical Care - July 14, 2014 Category: Intensive Care Authors: Jennifer A. Frontera, Wamda Ahmed Tags: Clinical Potpourri Source Type: research

The hepatic transcriptome of young suckling and aging intrauterine growth restricted male rats
Intrauterine growth restriction leads to the development of adult onset obesity/metabolic syndrome, diabetes mellitus, cardiovascular disease, hypertension, stroke, dyslipidemia, and non‐alcoholic fatty liver disease/steatohepatitis. Continued postnatal growth restriction has been shown to ameliorate many of these sequelae. To further our understanding of the mechanism of how intrauterine and early postnatal growth affects adult health we have employed Affymetrix microarray‐based expression profiling to characterize hepatic gene expression of male offspring in a rat model of maternal nutrient restriction in early and l...
Source: Journal of Cellular Biochemistry - November 7, 2014 Category: Biochemistry Authors: William A. Freije, Shanthie Thamotharan, Regina Lee, Bo‐Chul Shin, Sherin U. Devaskar Tags: Article Source Type: research

Ten-point plan to tackle liver disease published
"Doctors call for tougher laws on alcohol abuse to tackle liver disease crisis," The Guardian reports. But this is just one of 10 recommendations for tackling the burden of liver disease published in a special report in The Lancet.The report paints a grim picture of an emerging crisis in liver disease in the UK, saying it is one of the few countries in Europe where liver disease and deaths have actually increased rapidly over the last 30 years. It concludes with 10 recommendations to tackle the burden of liver disease.The media has approached the recommendations from many different angles, with many sources only ...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise QA articles Source Type: news

Offer weight loss surgery to obese people with diabetes
A quarter of the UK population is now obese, fuelling a rise in cases of type 2 diabetes, as well as heart disease, fatty liver disease and cancer. One in 20 people in the UK has type 2 diabetes, a progressive disease that causes heart disease, stroke, blindness, kidney failure and limb amputations. Updated NICE guidance focuses on identifying, assessing and treating people who are already obese.
Source: NHS Networks - December 1, 2014 Category: UK Health Authors: Maria Axford Source Type: news

7 Ways to Permanently Banish Belly Fat
Sixty-nine percent of Americans adults are overweight, and over 35 percent are obese. Obesity increases your risk for numerous conditions including heart disease, stroke, Type 2 diabetes, high blood pressure, and cancer. Sadly, about 3.4 million adults die each year from being overweight or obese. Globally obesity now kills about the same as tobacco and all wars, terrorism and violence. Nearly all people who are overweight already have "pre-diabetes" and have significant risks of disease and death. They just don't know it. When you begin to put on weight, especially lethal belly fat, your biology shifts out of balance, v...
Source: Healthy Living - The Huffington Post - February 27, 2015 Category: Consumer Health News Source Type: news

Study finds obese people may struggle to reach a healthy weight
ConclusionThis research makes use of a general practice database providing just under 10 years of BMI observations for a large, nationally representative UK sample. It demonstrates that low proportions of people in the obese categories were able to achieve a normal BMI over a year of follow-up, and the common problem of weight cycling. However, there are points to consider when interpreting these results: The probability of obtaining a normal BMI over a year was very low: only 1 in 210 for men and 1 in 124 for women in the "simple obese" category of 30 to 35kg/m2, and much lower than that for the higher categor...
Source: NHS News Feed - July 20, 2015 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Relationship of sitting time and physical activity with non-alcoholic fatty liver disease
Physical activity is well-recognized to reduce the incidence and mortality of various chronic diseases, including cardiovascular disease, diabetes, stroke and several types of cancer [1–3]. More than one half of the average person’s waking day involves sedentary activities associated with prolonged sitting such as watching TV and using the computer [4]. Recently, the deleterious effects of sedentary behavior regardless of additional physical activity have received a great deal of attention [5–8].
Source: Journal of Hepatology - September 14, 2015 Category: Gastroenterology Authors: Seungho Ryu, Yoosoo Chang, Hyun-Suk Jung, Kyung Eun Yun, Min-Jung Kwon, Yuni Choi, Chan-Won Kim, Juhee Cho, Byung-Seong Suh, Yong Kyun Cho, Eun Chul Chung, Hocheol Shin, Yeon Soo Kim Tags: Research Article Source Type: research

High-fructose diet hampers recovery from traumatic brain injury
A diet high in processed fructose sabotages rats’ brains’ ability to heal after head trauma, UCLA neuroscientists report. Revealing a link between nutrition and brain health, the finding offers implications for the 5.3 million Americans living with a traumatic brain injury, or TBI. According to the Centers for Disease Control and Prevention, an estimated 1.7 million people suffer a TBI each year, resulting in 52,000 annual deaths “Americans consume most of their fructose from processed foods sweetened with high-fructose corn syrup,” said Fernando Gomez-Pinilla, a professor of neurosurgery and integrative biology an...
Source: UCLA Newsroom: Health Sciences - October 2, 2015 Category: Universities & Medical Training Source Type: news

Low alanine aminotransferase levels and higher number of cardiovascular events in people with Type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
ConclusionsThe data may indicate that in people with Type 2 diabetes, which is associated with higher alanine aminotransferase levels because of prevalent non‐alcoholic fatty liver disease, a low alanine aminotransferase level is a marker of hepatic or systemic frailty rather than health.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - October 3, 2015 Category: Endocrinology Authors: K. H. Williams, D. R. Sullivan, A. S. Veillard, R. O'Brien, J. George, A. J. Jenkins, S. Young, C. Ehnholm, A. Duffield, S. M. Twigg, A. C. Keech Tags: Research Article Source Type: research

Association of whole blood viscosity with non-alcoholic fatty liver disease.
CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors. PMID: 26444605 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - September 25, 2015 Category: Hematology Authors: Yu XY, Li Y, Liu T, Wang RT Tags: Clin Hemorheol Microcirc Source Type: research

Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
ABSTRACTCarthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various documents. This review aims to provide up-to-date information on the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos in China and thereby to provide a basis for further investigation o...
Source: Revista Brasileira de Farmacognosia - November 17, 2015 Category: Drugs & Pharmacology Source Type: research