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Condition: Fatty Liver Disease (FLD)

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Total 312 results found since Jan 2013.

Clinical Characteristics  of Inpatients With New-Onset Diabetes Mellitus in Eastern China: Based on Novel Clustering Analysis
ConclusionsThe inpatients with new-onset diabetes in Eastern China had the unique clustering distribution. The clinical characteristics, treatments, and diabetes-related complications and comorbidities of the five subgroups were different, which may provide the basis for precise treatments of diabetes.
Source: Frontiers in Endocrinology - July 27, 2022 Category: Endocrinology Source Type: research

Complete alcohol abstinence increases the risk of NAFLD but not severity. A population analysis with transient elastography
CONCLUSION: Interestingly, modest alcohol consumption is associated with decreased odds of NAFLD. Further investigations are required to examine the relationship between alcohol consumption and NAFLD and subsequently the potential impact on NAFLD management.PMID:35944527 | DOI:10.1080/00365521.2022.2105168
Source: Scandinavian Journal of Gastroenterology - August 9, 2022 Category: Gastroenterology Authors: Jieling Xiao Cheng Han Ng Kai En Chan Ansel Shao Pin Tang Readon Teh Abel Ho Zhi Ling Jie Ning Yong Wen Hui Lim Darren Jun Hao Tan Caitlyn Tan Khin Maung Win Aung Hlaing Bwa Nicholas W S Chew Daniel Huang Yock Young Dan Mazen Noureddin Mohammad Shadab Sid Source Type: research

Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease
CONCLUSIONS: Amongst patients with T2DM, recent ACS, and a moderate-to-high likelihood of advanced liver fibrosis, apabetalone was associated with a significantly lower rate of ischemic MACE and HHF and attenuated the increase in hepatic FS over time.PMID:36039183 | PMC:PMC9419281 | DOI:10.1016/j.ajpc.2022.100372
Source: Atherosclerosis - August 30, 2022 Category: Cardiology Authors: Peter P Toth Gregory G Schwartz Stephen J Nicholls Aziz Khan Michael Szarek Henry N Ginsberg Jan O Johansson Kamyar Kalantar-Zadeh Ewelina Kulikowski Ken Lebioda Norman C W Wong Michael Sweeney Kausik K Ray BETonMACE Investigators Source Type: research

Long-term cardiovascular outcomes differ across metabolic dysfunction-associated fatty liver disease subtypes among middle-aged population
ConclusionLong-term cardiovascular disease outcomes differed across the MAFLD subtypes. Further studies are required to investigate whether preventive or therapeutic interventions should be optimized according to the MAFLD subtypes.
Source: Hepatology International - September 7, 2022 Category: Infectious Diseases Source Type: research

Optimising the management of cardiovascular comorbidities in NAFLD patients: its time to (re-) act!
With great interest, we have read the recent article by Simon et al,1 reporting a significant association between non-alcoholic fatty liver disease (NAFLD) and incident major adverse cardiovascular events. The authors found that patients with biopsy-proven NAFLD had a significantly higher incidence of ischaemic heart disease, stroke, congestive heart failure and death due to cardiovascular disease (CVD), when compared with matched controls. An excess in CVD morbidity and mortality was evident across all stages of NAFLD and increased with worsening disease severity. The authors are to be congratulated for conducting such a ...
Source: Gut - October 7, 2022 Category: Gastroenterology Authors: Kasper, P., Lang, S., Demir, M., Steffen, H.-M. Tags: Gut PostScript Source Type: research

Association of Bariatric Surgery With Cardiovascular Outcomes in Adults With Severe Obesity and Nonalcoholic Fatty Liver Disease
CONCLUSIONS AND RELEVANCE: Results of this study suggest that, compared with nonsurgical care, bariatric surgery was associated with significant reduction in CVD risk in individuals with severe obesity and NAFLD.PMID:36205997 | DOI:10.1001/jamanetworkopen.2022.35003
Source: Atherosclerosis - October 7, 2022 Category: Cardiology Authors: Mohamed I Elsaid You Li John F P Bridges Guy Brock Carlos D Minacapelli Vinod K Rustgi Source Type: research

A network-based approach for isolating the chronic inflammation gene signatures underlying complex diseases towards finding new treatment opportunities
Complex diseases are associated with a wide range of cellular, physiological, and clinical phenotypes. To advance our understanding of disease mechanisms and our ability to treat these diseases, it is critical to delineate the molecular basis and therapeutic avenues of specific disease phenotypes, especially those that are associated with multiple diseases. Inflammatory processes constitute one such prominent phenotype, being involved in a wide range of health problems including ischemic heart disease, stroke, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodege...
Source: Frontiers in Pharmacology - October 12, 2022 Category: Drugs & Pharmacology Source Type: research

NAFLD in Cardiovascular Diseases: A Contributor or Comorbidity?
In conclusion, a more comprehensive, multidisciplinary approach to diagnosis and management of patients with NAFLD and cardiovascular diseases is needed to optimize clinical outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Liver Disease - October 14, 2022 Category: Gastroenterology Authors: Chen, Bing Tang, W.H Wilson Rodriguez, Mario Corey, Kathleen E. Sanyal, Arun J. Kamath, Patrick S. Bozkurt, Biykem Virk, Hafeez Ul Hassan Pressman, Gregg S. Lazarus, Jeffrey V. El-Serag, Hashem B. Krittanawong, Chayakrit Tags: Review Article Source Type: research

Risk factors for cardiovascular disease  in patients with metabolic-associated fatty liver disease: a machine learning approach
CONCLUSION: A ML approach demonstrated high performance in identifying MAFLD patients with prevalent CVD based on the easy-to-obtain patient parameters.PMID:36371249 | DOI:10.1186/s12933-022-01672-9
Source: Atherosclerosis - November 12, 2022 Category: Cardiology Authors: Karolina Dro żdż Katarzyna Nabrdalik Hanna Kwiendacz Mirela Hendel Anna Olejarz Andrzej Tomasik Wojciech Bartman Jakub Nalepa Janusz Gumprecht Gregory Y H Lip Source Type: research

IJERPH, Vol. 20, Pages 1682: Low-Grade Inflammation and Role of Anti-Inflammatory Diet in Childhood Obesity
At present, pediatric obesity is a significant public health concern. We have seen a surge of disorders that are obesity-related, e.g., insulin resistance (IR), type 2 diabetes mellitus (T2DM), high blood pressure, heart disease, stroke, cancer, non-alcoholic fatty liver disease (NAFLD), autoimmune disorders and many more. The mechanisms linking these diseases to excess body weight are related to low-grade inflammation (LGI). Although there is a limited number of studies assessing this immune process in childhood obesity, they indicate its significant importance for the health of future generations. There is a need fo...
Source: International Journal of Environmental Research and Public Health - January 17, 2023 Category: Environmental Health Authors: Ewelina Polak-Szczyby ło Tags: Review Source Type: research

Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease
Conclusion Compared with matched population controls, children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure. Research to better characterise cardiovascular risk in children and young adults with NAFLD should be prioritised.
Source: Gut - February 7, 2023 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Alkhouri, N., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

Intersectoral management of patients with abnormal liver enzymes and non-alcoholic fatty liver disease (NAFLD)
Z Gastroenterol. 2023 Feb 15. doi: 10.1055/a-1957-5671. Online ahead of print.ABSTRACTThe prevalence of fatty liver disease has increased significantly in Germany in recent years. With an estimated 18 million German citizens being affected, it is now among the most prevalent diseases. Furthermore, it is also considered a relevant and independent risk factor for other common cardiovascular diseases such as heart attack or stroke. Finally, diabetes mellitus promotes the development of and an unfavorable course of fatty liver disease. Given the high prevalence and complications, the German healthcare system is reaching its li...
Source: Zeitschrift fur Gastroenterologie - February 15, 2023 Category: Gastroenterology Authors: Andreas Teufel Andreas Geier Christoph Sarrazin J örn M Schattenberg Achim Kautz Rebecca Dorner Jan Kramer Katrin Jerysiak Theodor Baars Bastian H önscheid Dirk M üller-Wieland Siegbert Rossol Christian Trautwein Frank Tacke Ali Canbay Source Type: research