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Condition: Ischemic Stroke
Cancer: Brain Cancers
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Total 832 results found since Jan 2013.
Neuroprotective effects of visnagin on cerebral ischemia-reperfusion injury rats and the underlying mechanisms
CONCLUSIONS: Visnagin exerts a neuroprotective effect during I/R injury in rats, the underlying mechanisms may be the effect of attenuating neuroinflammation, anti-oxidative and inhibition of apoptosis.PMID:35776038 | DOI:10.26355/eurrev_202206_29076
Source: European Review for Medical and Pharmacological Sciences - July 1, 2022 Category: Drugs & Pharmacology Authors: X-L Rao L-L Liu J Huang J Chen Source Type: research
Anti-apoptosis effects of codonolactone on cerebral ischemia-reperfusion injury
This study investigated the roles of codonolactone in inflammation, oxidative stress and apoptosis after cerebral ischemia-reperfusion (I/R) injury. Rats with codonolactone treatment, I/R treatment and the sham operation group were used in this study. After reperfusion for 24 hours, nerve damage was detected by nerve staining, and the neurological deficits of the rats were analyzed. The contents of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in rat brain tissues were also determined. Western blot analysis was performed to determine the ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Chen, F., Lin, W. Tags: Original research Source Type: research
Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1
Cell Transplant. 2022 Jan-Dec;31:9636897221102898. doi: 10.1177/09636897221102898.ABSTRACTMesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to promote angiogenesis. Treating MSCs with ischemic rat brain extracts was sufficient to augment their benefits in stroke. However, no similar analyses of ischemic heart extracts have been performed to date. We aim to determine whether MSC-Exos derived from MSCs pretreated with ischemic rat heart extract were able to promote angiogenesis and to clarify underlying mechanisms. ELISA (enzyme-linked immunosorbent assay) of heart extracts revealed a significant increase of ...
Source: Cell Transplantation - June 21, 2022 Category: Cytology Authors: Yi Xiao Ye Zhang Yuzhang Li Nanyin Peng Qin Liu Danyang Qiu Justin Cho Cesario V Borlongan Guolong Yu Source Type: research
Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide
Cell Rep Med. 2022 Jun 9:100654. doi: 10.1016/j.xcrm.2022.100654. Online ahead of print.ABSTRACTBrain edema after a large stroke causes significant morbidity and mortality. Here, we seek to identify pharmacodynamic markers of edema that are modified by intravenous (i.v.) glibenclamide (glyburide; BIIB093) treatment. Using metabolomic profiling of 399 plasma samples from patients enrolled in the phase 2 Glyburide Advantage in Malignant Edema and Stroke (GAMES)-RP trial, 152 analytes are measured using liquid chromatography-tandem mass spectrometry. Associations with midline shift (MLS) and the matrix metalloproteinase-9 (MM...
Source: Cancer Control - June 14, 2022 Category: Cancer & Oncology Authors: Hannah J Irvine Animesh Acharjee Zoe Wolcott Zsuzsanna Ament H E Hinson Bradley J Molyneaux J Marc Simard Kevin N Sheth W Taylor Kimberly Source Type: research
Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury
Stroke is one of the leading causes of mortality, and survivors experience serious neurological and motor behavioral deficiencies. Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur because of ischemia/reperfusion injury. Wnt signaling is an evolutionarily conserved signaling pathway that has been manifested to play a key role in embryo development and function maintenance in adults. Overactivation of Wnt signaling has previously been investigated in cancer-based research studies. Recently, abnormal Wnt signaling activity has been observed in ischemic stroke, which ...
Source: Frontiers in Pharmacology - May 20, 2022 Category: Drugs & Pharmacology Source Type: research
Identification of novel and potential PPAR γ stimulators as repurposed drugs for MCAO associated brain degeneration
Toxicol Appl Pharmacol. 2022 May 9:116055. doi: 10.1016/j.taap.2022.116055. Online ahead of print.ABSTRACTPeroxisome proliferator-activated receptor-gamma (PPARγ) has been shown to have therapeutic promise in the treatment of ischemic stroke and is supported by several studies. To identify possible PPARγ activators, the current study used an in silico technique in conjunction with molecular simulations and in vivo validation. FDA-approved drugs were evaluated using molecular docking to determine their affinity for PPARγ. The findings of molecular simulations support the repurposing of rabeprazole and ethambutol for the ...
Source: Toxicology and Applied Pharmacology - May 13, 2022 Category: Toxicology Authors: Halima Usman Zhen Tan Mehreen Gul Sajid Rashid Tahir Ali Fawad Ali Shah Shupeng Li Jing Bo Li Source Type: research
Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors
Conclusions
This technique of perfusion guided-ESIA injections (PG-ESIA) enhances our ability to perform targeted super-selective delivery of therapeutic agents for brain tumors.
Source: Journal of NeuroInterventional Surgery - May 13, 2022 Category: Neurosurgery Authors: Chen, S. R., Chen, M. M., Ene, C., Lang, F. F., Kan, P. Tags: Editor''s choice New devices and techniques Source Type: research
Involvement of Ceramide Metabolism in Cerebral Ischemia
Front Mol Biosci. 2022 Apr 20;9:864618. doi: 10.3389/fmolb.2022.864618. eCollection 2022.ABSTRACTIschemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in worldwide. Although reperfusion therapies have shown efficacy in a limited number of patients with acute ischemic stroke, neuroprotective drugs and recovery strategies have been widely assessed, but none of them have been successful in clinical practice. Therefore, the search for new therapeutic approaches is still necessary. Sphingolipids consist of a family of lipidic molecul...
Source: Atherosclerosis - May 9, 2022 Category: Cardiology Authors: Alberto Ouro Clara Correa-Paz Elena Maqueda Ant ía Custodia Marta Aramburu-N úñez Daniel Romaus-Sanjurjo Adri án Posado-Fernández Mar ía Candamo-Lourido Maria Luz Alonso-Alonso Pablo Hervella Ram ón Iglesias-Rey Jos é Castillo Francisco Campos Tom Source Type: research
