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Involvement of Ceramide Metabolism in Cerebral Ischemia
Front Mol Biosci. 2022 Apr 20;9:864618. doi: 10.3389/fmolb.2022.864618. eCollection 2022.ABSTRACTIschemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in worldwide. Although reperfusion therapies have shown efficacy in a limited number of patients with acute ischemic stroke, neuroprotective drugs and recovery strategies have been widely assessed, but none of them have been successful in clinical practice. Therefore, the search for new therapeutic approaches is still necessary. Sphingolipids consist of a family of lipidic molecul...
Source: Atherosclerosis - May 9, 2022 Category: Cardiology Authors: Alberto Ouro Clara Correa-Paz Elena Maqueda Ant ía Custodia Marta Aramburu-N úñez Daniel Romaus-Sanjurjo Adri án Posado-Fernández Mar ía Candamo-Lourido Maria Luz Alonso-Alonso Pablo Hervella Ram ón Iglesias-Rey Jos é Castillo Francisco Campos Tom Source Type: research

Therapeutic effect of anti-HMGB1 antibody in a mouse model of 4-h middle cerebral artery occlusion: comparison with tissue plasminogen activator
Conclusion These results indicate that αHMGB1 antibody may be therapeutically efficient in the delayed phase of ischemia, where tPA treatment is no longer an eligible option. Treatment with an αHMGB1 antibody may be an effective therapeutic option in patients who exceed the tPA therapeutic time window.
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Multidelay ASL of the pediatric brain
Br J Radiol. 2022 Apr 22:20220034. doi: 10.1259/bjr.20220034. Online ahead of print.ABSTRACTArterial spin labeling (ASL) is a powerful noncontrast MRI technique for evaluation of cerebral blood flow (CBF). A key parameter in single-delay ASL is the choice of postlabel delay (PLD), which refers to the timing between the labeling of arterial free water and measurement of flow into the brain. Multidelay ASL (MDASL) utilizes several PLDs to improve the accuracy of CBF calculations using arterial transit time (ATT) correction. This approach is particularly helpful in situations where ATT is unknown, including young subjects and...
Source: The British Journal of Radiology - April 22, 2022 Category: Radiology Authors: Xavier Golay Mai-Lan Ho Source Type: research

Interleukin-1 Mediates Ischemic Brain Injury via Induction of IL-17A in γδ T Cells and CXCL1 in Astrocytes
AbstractAs a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate the underlying cell-type-specific IL-1 effects, we subjected IL-1 ( α/β) knockout (Il1−/−) and wildtype (WT) littermate mice to permanent middle cerebral artery occlusion (pMCAO) and assessed immune cell infiltration and cytokine production in the ischemic hemisphere by flow cytometry 24  h and 72 h after stroke.Il1−/− mice showed smaller infarcts and reduced neutrophil infiltration into the ischemic brain. We identified γδ T ...
Source: NeuroMolecular Medicine - April 6, 2022 Category: Neurology Source Type: research

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