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Condition: Ischemic Stroke
Cancer: Brain Cancers
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Total 832 results found since Jan 2013.
Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients: Impact of cancer and ventilatory support status
This study suggests COVID-19 is associated with neurological manifestations that may be visible with brain imaging techniques such as MRI. In our COVID-19 cohort, there was no association between cancer status and neuroimaging findings. Future studies might include more prospectively enrolled systematically characterized patients, allowing for more rigorous statistical analysis.
Source: PLoS One - March 24, 2023 Category: Biomedical Science Authors: Lily McCarthy Source Type: research
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
AbstractThe molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role ofApold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression ofApold1 is restricted to the vasculature and thatApold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. UsingApold1−/− mice, we find thatApold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the ...
Source: Angiogenesis - March 18, 2023 Category: Molecular Biology Source Type: research
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR- γ pathway after ischemic stroke
Cell Immunol. 2023 Mar 5;386:104704. doi: 10.1016/j.cellimm.2023.104704. Online ahead of print.ABSTRACTExploring regimens to facilitate microglia transformation from M1 to M2 phenotype is a feasible strategy to suppress neuroinflammation, therefore reinforcing functional recovery after ischemic stroke. Muscone easily crosses the blood brain barrier (BBB) and distributes throughout the brain. Here, the results illustrated the administration of 8 mg/kg muscone promoted functional recovery through reducing the infarct volume by 2,3,5-triphenyltetrazolium chloride (TTC) staining after ischemic stroke in mice. Then, the express...
Source: Cellular Immunology - March 15, 2023 Category: Allergy & Immunology Authors: Fei Liu Liwei Cao Shejing Hu Hongxiang Ye Qiang Wu Le Wu Source Type: research
MRI for all: Cheap portable scanners aim to revolutionize medical imaging
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The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing.
The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research
Protective Effect of Erythromycin Pre-adaptation on Focal Cerebral Ischemia in Rats and its Changes in TNF- α and nNOS
CONCLUSIONS: Erythromycin preconditioning had a protective effect against focal cerebral ischemia in rats, and the best protective effect occurred for the 35-mg/kg preconditioning. The reason may be related to the fact that erythromycin preconditioning significantly upregulated nNOS and downregulated TNF-α in the brain tissue.PMID:36795522
Source: Alternative Therapies in Health and Medicine - February 16, 2023 Category: Complementary Medicine Authors: Danqing Gou Rimiao Yang Weicheng Lu Shangchen Han Mingbin Si Guangyu Li Source Type: research
Regulation of the p53 ‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
Exp Ther Med. 2023 Jan 26;25(3):113. doi: 10.3892/etm.2023.11812. eCollection 2023 Mar.ABSTRACTStroke is one of the most threatening diseases worldwide, particularly in countries with larger populations; it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel ruptures) or ischemic stroke (blockage of an artery). Whilst the incidence of stroke is higher in the elderly population (≥65), it is also increasing in the younger population. Ischemic stroke accounts for ~85% of a...
Source: Experimental and Therapeutic Medicine - February 16, 2023 Category: General Medicine Authors: Shuangli Xu Xuewei Li Yanqiang Wang Source Type: research
Protective Effect of Erythromycin Pre-adaptation on Focal Cerebral Ischemia in Rats and its Changes in TNF- α and nNOS
CONCLUSIONS: Erythromycin preconditioning had a protective effect against focal cerebral ischemia in rats, and the best protective effect occurred for the 35-mg/kg preconditioning. The reason may be related to the fact that erythromycin preconditioning significantly upregulated nNOS and downregulated TNF-α in the brain tissue.PMID:36795522
Source: Alternative Therapies in Health and Medicine - February 16, 2023 Category: Complementary Medicine Authors: Danqing Gou Rimiao Yang Weicheng Lu Shangchen Han Mingbin Si Guangyu Li Source Type: research
