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Innovative technique to examine blood vessels in 3D help unlock secrets of the brain
An important breakthrough has been made in the examination of blood vessels in the brain giving scientists a clearer understanding of how dementia, brain cancer and stroke can affect veins and capillaries in this organ.
Source: ScienceDaily Headlines - January 5, 2017 Category: Science Source Type: news

Targeting sonic hedgehog signaling in neurological disorders
In conclusion, further studies are warranted to demonstrate the potential of positive and negative regulators of the Shh pathway in neurological disorders.
Source: Neuroscience and Biobehavioral Reviews - January 16, 2017 Category: Neuroscience Source Type: research

2017 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. The Special Report examines how the use of biomarkers may influence the AD diagnostic process and estimates of prevalence and incidence of the disease. An estimated 5.5 million Americans have Alzheimer's dementia. By mid-century, the number of people living with Alzheimer's dementia in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someone in the country develo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 14, 2017 Category: Geriatrics Source Type: research

Calcified Amorphous Tumor Causing Shower Embolism to the Brain: A Case Report with Serial Echocardiographic and Neuroradiologic Images and a Review of the Literature
An 89-year-old woman with chronic atrial fibrillation, hypertension, chronic heart failure, and dementia was admitted to our hospital due to multiple small cerebral and cerebellar infarctions. Transthoracic echocardiogram revealed a floating calcified mass lesion arising from the endocardium of the posterior portion of the mitral annulus with mitral annular calcification. Furthermore, the mass had a heterogeneity of the echogenicity. The mass was diagnosed as a calcified amorphous tumor based on specific echocardiographic features.
Source: Journal of Stroke and Cerebrovascular Diseases - March 17, 2017 Category: Neurology Authors: Takaomi Singu, Yuichiro Inatomi, Toshiro Yonehara, Yukio Ando Tags: Case Studies Source Type: research

Two older drugs could be 'repurposed' to fight dementia
Conclusion This early stage experimental research has demonstrated a beneficial neurological effect of trazodone and dibenzoylmethane on mice with diseases mimicking neurodegenerative diseases. It is important to acknowledge that this is animal research and therefore the drugs might not have the same effect when they are trialled on humans. That being said, trazodone is already an approved drug for depression and sleep problems and has therefore already passed safety tests. If the mechanisms of neurodegeneration in humans and mice are similar, it is possible trazodone could be used in the future in treating Alzheimer's and...
Source: NHS News Feed - April 20, 2017 Category: Consumer Health News Tags: Older people Neurology Medication Source Type: news

Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research

Palliative Care in Neurology
Palliative medicine is a specialty that focuses on improving the quality of life for patients with serious or advanced medical conditions, and it is appropriate at any stage of disease, including at the time of diagnosis. Neurologic conditions tend to have high symptom burdens, variable disease courses, and poor prognoses that affect not only patients but also their families and caregivers. Patients with a variety of neurologic conditions such as Parkinson disease, dementia, amyotrophic lateral sclerosis, brain tumors, stroke, and acute neurologic illnesses have substantial unmet needs that can be addressed through a combi...
Source: Mayo Clinic Proceedings - October 1, 2017 Category: Internal Medicine Authors: Maisha T. Robinson, Robert G. Holloway Tags: Symposium on neurosciences Source Type: research

Seizure Bootcamp: Everything You Ever Needed to Know to Manage Seizures in End Stage Disease (FR455)
Seizures are a common occurrence in end stage disease, occurring in a wide range of conditions, including dementia, stroke, AIDS, end stage renal disease, and both primary brain tumors and metastatic disease. Not only are uncontrolled seizures a significant source of distress to both patient and families, but they present a significant management challenge to the hospice team, who are often faced with controlling seizures in the face of advancing disease, increasing seizure risk factors, and declining ability of the patient to take oral medications.
Source: Journal of Pain and Symptom Management - February 1, 2018 Category: Palliative Care Authors: Mara Lugassy, Neha Kramer, Ebtesam Ahmed, Joel Phillips, Colleen Fleming-Damon Source Type: research

2018 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on caregivers and society. The Special Report examines the benefits of diagnosing Alzheimer's earlier in the disease process, in the stage of mild cognitive impairment due to Alzheimer's disease. An estimated 5.7 million Americans have Alzheimer's dementia. By mid-century, the number of people living with Alzheimer's dementia in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2015, o...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 20, 2018 Category: Geriatrics Source Type: research

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Maxime Gauberti, Antoine P. Fournier, Fabian Docagne, Denis Vivien, Sara Martinez de Lizarrondo Tags: Review Source Type: research

There ’s New Hope For Preventing Alzheimer’s — And It Could Be Within Your Control
Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke. What...
Source: TIME: Health - August 9, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Aging Alzheimer's Research Source Type: news

Researchers Think Preventing Alzheimer ’s Might Actually Be Within Your Control
Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke. What...
Source: TIME: Health - August 9, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Aging Alzheimer's Research Source Type: news

Lowering Your Blood Pressure Could Reduce Alzheimer ’s Risk, New Research Shows
Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke. What...
Source: TIME: Health - August 9, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Aging Alzheimer's Research Source Type: news

Should You Take Aspirin Every Day? Here ’s What the Science Says
Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affe...
Source: TIME: Health - November 8, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs healthytime Source Type: news

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