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Total 1307 results found since Jan 2013.
Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib
CONCLUSION: In tofacitinib-treated patients with PsA/PsO, increased ASCVD risk and baseline MetS were associated with higher IRs for MACE and malignancies. Our results support assessing CV risk in patients with PsA/PsO and suggest enhanced cancer monitoring in those with increased ASCVD risk.REGISTRATION CLINICALTRIALSGOV: NCT01877668/NCT01882439/NCT01976364/NCT00678210/NCT01710046/NCT01241591/NCT01186744/NCT01276639/NCT01309737/NCT01163253.PLAIN LANGUAGE SUMMARY: People who have psoriatic arthritis or psoriasis may have more heart-related problems and cancer if they have a higher risk of cardiovascular disease: A study in...
Source: Adv Data - February 13, 2023 Category: Epidemiology Authors: Lars E Kristensen Bruce Strober Denis Poddubnyy Ying-Ying Leung Hyejin Jo Kenneth Kwok Ivana Vranic Dona L Fleishaker Lara Fallon Arne Yndestad Dafna D Gladman Source Type: research
Does BMI Really Matter to Our Overall Health? Findings from a Cross-sectional Analysis of Middle-aged and Older Adults in India
AbstractWe explored the association of body mass index (BMI) with overall health among middle-aged and older Indian adults. The cross-sectional sample included 42,575 respondents (45 years) from the Longitudinal Aging Study in India (LASI), Wave 1 (2017-18), including middle-aged (23,811) and older adults (18,764). Overall health was assessed by using 19 health indicators, including 10 chronic diseases. Binary logistic regressions were utilized to examine the effect. The overweight and obese older adults were associated with higher life satisfaction (LS), happiness, better handgrip strength (HGS), better cognition (CS), an...
Source: Journal of Population Ageing - February 9, 2023 Category: International Medicine & Public Health Source Type: research
Vitamin D intake and all-cause and cause-specific mortality in Japanese men and women: the Japan Public Health Center-based prospective study
Eur J Epidemiol. 2023 Jan 31. doi: 10.1007/s10654-023-00968-8. Online ahead of print.ABSTRACTWhile higher circulating 25-hydroxyvitamin D concentrations have been reported to be associated with decreased risk of all-cause mortality, evidence on dietary vitamin D intake is limited and inconsistent. We investigated whether vitamin D intake is associated with all-cause and cause-specific mortality among Japanese adults. Participants were 42,992 men and 50,693 women who responded to the second survey of the Japan Public Health Center-based Prospective Study (1995-1998) and who were followed up for mortality through 2018. Dieta...
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: Akiko Nanri Tetsuya Mizoue Atsushi Goto Mitsuhiko Noda Norie Sawada Shoichiro Tsugane Japan Public Health Center-based Prospective Study Group Source Type: research
Enjoy the holiday spirit, not the holiday heart
The holidays are approaching. Many people will be gathering with family, friends, and loved ones. The holidays are filled with laughter, joy, gluttony, and festivity. There are some traditions that are unique to each family, but one tradition that is pervasive in western society is alcohol consumption. It is estimated that a quarter of the yearly sales of distilled spirits occur between Thanksgiving and New Year's Day.1 Alcohol consumption, especially in excess, is not without risk. Chronic alcohol abuse is associated with hypertension, stroke, liver damage, and an increased risk of cancer.
Source: The Journal of Thoracic and Cardiovascular Surgery - January 31, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ali Syed, Benjamin D. Seadler, David L. Joyce Tags: Letter to the Editor Source Type: research
America ’s Obsession With Alcohol- Will It Ever End?
Alcohol use, even at moderate amounts, is linked to a number of medical and health-related issues; including but not limited to an increase risk of cancers such as liver, esophagus, and breast; an increased risk of heart disease, stroke, and high blood pressure.
Source: Forbes.com Healthcare News - January 18, 2023 Category: Pharmaceuticals Authors: Omer Awan, Contributor Tags: Healthcare /healthcare Innovation /innovation Source Type: news
IJERPH, Vol. 20, Pages 1682: Low-Grade Inflammation and Role of Anti-Inflammatory Diet in Childhood Obesity
At present, pediatric obesity is a significant public health concern. We have seen a surge of disorders that are obesity-related, e.g., insulin resistance (IR), type 2 diabetes mellitus (T2DM), high blood pressure, heart disease, stroke, cancer, non-alcoholic fatty liver disease (NAFLD), autoimmune disorders and many more. The mechanisms linking these diseases to excess body weight are related to low-grade inflammation (LGI). Although there is a limited number of studies assessing this immune process in childhood obesity, they indicate its significant importance for the health of future generations. There is a need fo...
Source: International Journal of Environmental Research and Public Health - January 17, 2023 Category: Environmental Health Authors: Ewelina Polak-Szczyby ło Tags: Review Source Type: research
Pollutants In Your Salt!?
Your doctor, the media, and the medical establishment continue to warn that flavoring your food with salt will kill you. They link sodium consumption to a higher risk of high blood pressure, stroke – and of course, heart disease.
As usual, the powers that be are missing the real picture…
You see, salt has been part of human life for thousands of years – long before these chronic diseases became as common as they are today.
Humans started adding salt to their food for more than 5,000 years. It was the most effective way to preserve food.
Some historians even go as far as to credit salt for the development of human civ...
Source: Al Sears, MD Natural Remedies - December 23, 2022 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news
An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions
Conclusion:
Prospective studies of vitamin D supplementation demonstrate variable impact on disease specific and patient-oriented outcomes, suggesting a correlation but not a causal relationship between low vitamin D levels and disease pathogenicity. Future research should determine dosing standards and timing of vitamin D in treatment and prevention.
Source: Journal of the American Board of Family Medicine - December 23, 2022 Category: Primary Care Authors: Michael, W., Couture, A. D., Swedlund, M., Hampton, A., Eglash, A., Schrager, S. Tags: Clinical Review Source Type: research
The final puff: Can New Zealand quit smoking for good?
Smoking kills. Ayesha Verrall has seen it up close. As a young resident physician in New Zealand’s public hospitals in the 2000s, Verrall watched smokers come into the emergency ward every night, struggling to breathe with their damaged lungs. Later, as an infectious disease specialist, she saw how smoking exacerbated illness in individuals diagnosed with tuberculosis and HIV/AIDS. She would tell them: “The best thing you can do to promote your health, other than take the pills, is to quit smoking.”
Verrall is still urging citizens to give up cigarettes—no longer just one by one, but by the thousands. As New...
Source: ScienceNOW - December 9, 2022 Category: Science Source Type: news
Real-World Study Confirms Benefit of XARELTO ® (rivaroxaban) for Secondary Prevention of Venous Thromboembolism in Cancer Patients
TITUSVILLE, NJ, December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced observational data from eight years of clinical practice showing that the oral Factor Xa inhibitor XARELTO® (rivaroxaban) is associated with comparable effectiveness and safety to the Factor Xa inhibitor apixaban for the treatment of cancer-associated thromboembolism (CAT) in a broad cohort of patients with various cancer types. Patients with CAT are at a higher risk of venous thromboembolism (VTE), which is the second-leading cause of death in people with cancer.1Data from the Observational Study in Cancer-A...
Source: Johnson and Johnson - December 9, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news
Determining the safety and effectiveness of Tai Chi: a critical overview of 210 systematic reviews of controlled clinical trials
ConclusionsThe findings suggest Tai Chi has multidimensional effects, including physical, psychological and quality of life benefits for a wide range of conditions, as well as multimorbidity. Clinically important benefits were most consistently reported for Parkinson ’s disease, falls risk, knee osteoarthritis, low back pain, cerebrovascular, and cardiovascular diseases including hypertension. For most conditions, higher-quality SRs with rigorous primary studies are required.Systematic review registrationPROSPERO CRD42021225708.
Source: Systematic Reviews - December 3, 2022 Category: International Medicine & Public Health Source Type: research
Stroke, Dietary Fish, Milk, and Sugar Consumption Correlates of Alzheimer's and Parkinson's Dementia
To investigate the potentially confounding factors in the relationship between daily sugar intake versus Alzheimer& Parkinson's related death rates, including milk, meat, fish and alcohol consumption; obesity, stroke, hypertension, cancer and diabetes rates; tobacco use; and gross domestic purchasing power parity in different countries.
Source: Archives of Physical Medicine and Rehabilitation - December 1, 2022 Category: Rehabilitation Authors: Kurt Gold, Jacob Galloway, Justin Schwartz, Jonathan Huefner, Elizabeth Call, Taoyuan Beninato, Gabriela Garaycochea, Ronald Bulbulian Tags: Research Poster 2184247 Source Type: research
Changes in coverage among non-elderly adults with chronic diseases following Affordable Care Act implementation
by John D. Goodson, Sara Shahbazi, Zirui Song
ImportanceChanges in insurance coverage after the Affordable Care Act (ACA) among non-elderly adults with self-reported chronic conditions across income categories have not been described. ObjectiveTo examine changes in insurance coverage after the ACA among non-elderly adults with chronic conditions across income categories, by geographic region. DesignWe compared self-reported access to health insurance pre-ACA (2010-2013) and post-ACA (2014-2017) for individuals 18-64 years of age with ≥ 2 chronic conditions, including hypertension, heart disease/stroke, emphysema, diabete...
Source: PLoS One - November 30, 2022 Category: Biomedical Science Authors: John D. Goodson Source Type: research
Multimorbidity burden and developmental trajectory in relation to later-life dementia: A prospective study
CONCLUSIONS: Both multimorbidity burden and its developmental trajectory were prospectively associated with risk of dementia.PMID:36427050 | DOI:10.1002/alz.12840
Source: The Journal of Alzheimers Association - November 25, 2022 Category: Psychiatry Authors: Hui Chen Yaguan Zhou Liyan Huang Xiaolin Xu Changzheng Yuan Source Type: research
