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Total 736 results found since Jan 2013.
Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts
Gen Physiol Biophys. 2022 Sep;41(5):381-392. doi: 10.4149/gpb_2022027.ABSTRACTBoth vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantly promoted the generation of ROS, MDA and 4-HNE, reduced the activities of SOD, GST and GR, increased Fe2+ concentration and inhibited GPX4 expression through circ0004372/miR-124/SERTAD4. Both UII and ferroptosis inducer Erastin significantly pro...
Source: General Physiology and Biophysics - October 12, 2022 Category: Physiology Authors: Yan-Chao Hu Tuo Han Ya-Jie Fan Chun-Yan Zhang Yan Zhang Wei-Dong Ma Cong-Xia Wang Source Type: research
Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells
Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable nonselective cation channel whose dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 is present in different cell locations, including the primary cilium of renal epithelial cells. However, little is known as to whether PC2 contributes to the primary cilium structure. Here, we explored the effect(s) of external Ca2+, PC2 channel blockers, and PKD2 gene silencing on the length of primary cilia in wild-type LLC-PK1 renal epithelial cells. Confluent cell monolayers were fixed and immuno-labeled with an anti-acetylated α-tubulin antibody to identify pr...
Source: Frontiers in Physiology - October 4, 2022 Category: Physiology Source Type: research
Function of Vitellogenin receptor gene in reproductive regulation of Zeugodacus cucurbitae (Coquillett) after short-term high-temperature treatment
Climate change has increased the frequency of extreme heat events. Zeugodacus cucurbitae (Coquillett) is an important tropical pest that typically changes its reproductive strategies in response to extremely high temperatures. Newly emerged adults of three consecutive generations (F1, F2, and F3) of Z. cucurbitae (Coquillett) were exposed to 25°C, 33°C, 37°C, 41°C, and 45°C treatments for 1 h to clarify the effects of short-term high temperatures on its reproduction. The influence of these temperatures on reproduction was evaluated using indicators, such as egg number. Newly emerged adults were exposed to 25°C and 4...
Source: Frontiers in Physiology - October 4, 2022 Category: Physiology Source Type: research
SNAT2 is responsible for hyperosmotic induced sarcosine and glycine uptake in human prostate PC-3 cells
Pflugers Arch. 2022 Sep 29. doi: 10.1007/s00424-022-02752-1. Online ahead of print.ABSTRACTSolute carriers (SLC) are important membrane transport proteins in normal and pathophysiological cells. The aim was to identify amino acid SLC(s) responsible for uptake of sarcosine and glycine in prostate cancer cells and investigate the impact hereon of hyperosmotic stress. Uptake of 14C-sarcosine and 3H-glycine was measured in human prostate cancer (PC-3) cells cultured under isosmotic (300 mOsm/kg) and hyperosmotic (500 mOsm/kg) conditions for 24 h. Hyperosmotic culture medium was obtained by supplementing the medium with 200 mM ...
Source: Pflugers Archiv : European Journal of Physiology - September 29, 2022 Category: Physiology Authors: Carsten Uhd Nielsen Nanna Friberg Krog Ilham Sjekirica Sidsel Strandgaard Nielsen Maria L Pedersen Source Type: research
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research
