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Total 736 results found since Jan 2013.

NADPH oxidase 4 contributes to oxidative stress in a mouse model of myocardial infarction
Physiol Res. 2023 Apr 30;72(2):177-186. doi: 10.33549/physiolres.934992.ABSTRACTOxidative stress closely related to the progression and severity of myocardial infarction (MI). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the major enzymes that generate reactive oxygen species (ROS) in cardiovascular system. Here, we aim to elucidate the pathological role of NOX4 in MI. MI mouse model was created by the coronary artery ligation. NOX4 was specifically knocked down in heart through intramyocardial injection of siRNA. NOX4 expression and oxidative stress indicators were determined at different...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: Q Huang Y Chen Source Type: research

Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth
Conclusion: These results support the conclusion that cofilin activation plays a pivotal convergent role for various cell signaling cascades in CCK mediated growth/enzyme secretion in pancreatic acini.
Source: Frontiers in Physiology - April 17, 2023 Category: Physiology Source Type: research

TOM complex ‐independent transport pathway of myoglobin into mitochondria in C2C12 myotubes
The purpose of this study was to investigate the involvement of the TOM complex in Mb import into the mitochondria. A knockdown experiment using siRNA for Tom40 did not alter the amount of Mb expression in the mitochondrial fraction, suggesting that Mb does not necessarily require the TOM complex for mitochondrial import of Mb. AbstractRecently, we found that myoglobin (Mb) localizes in both the cytosol and mitochondrial intermembrane space in rodent skeletal muscle. Most proteins of the intermembrane space pass through the outer mitochondrial membrane via the translocase of the outer membrane (TOM) complex. However, wheth...
Source: Physiological Reports - April 6, 2023 Category: Physiology Authors: Rikuhide Koma, Tsubasa Shibaguchi, Yuhei Araiso, Tatsuya Yamada, Yudai Nonaka, Thomas Jue, Kazumi Masuda Tags: ORIGINAL ARTICLE Source Type: research

C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition
In this study, we proposed C-type natriuretic peptide (CNP) as a potential mediator of this sympatho-inhibition within the PVN. Microinjection of CNP (1.0 μg) into the PVN significantly decreased renal sympathetic nerve activity (RSNA) (−25.8% ± 1.8% vs. −3.6% ± 1.5%), mean arterial pressure (−15.0 ± 1.9 vs. −0.1 ± 0.9 mmHg) and heart rate (−23.6 ± 3.5 vs. −0.3 ± 0.9 beats/min) compared with microinjection of vehicle. Picoinjection of CNP significantly decreased the basal discharge of extracellular single-unit recordings in 5/6 (83%) rostral ventrolateral medulla (RVLM)-projecting PVN neurons and in 6/...
Source: Frontiers in Physiology - April 4, 2023 Category: Physiology Source Type: research

Mice with endothelial cell ‐selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction
Endothelial cell-selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. We propose that animals deficient in ESAM develop left ventricular diastolic dysfunction due to reduced myocardial vascular density, hypoxia, and inflammation. Hemodynamic challenge lead to worsening of left ventricular diastolic dysfunction in ESAM knockout mice. AbstractEndothelial cell-selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. Here, we examined the role of ESAM in cardiac vascularization, inflammatory cell infilt...
Source: Physiological Reports - March 22, 2023 Category: Physiology Authors: Vadym Buncha, Katie Anne Fopiano, Liwei Lang, Celestine Williams, Anatolij Horuzsko, Jessica Andrea Filosa, Gaston Kapuku, Zsolt Bagi Tags: ORIGINAL ARTICLE Source Type: research

Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes
This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional genomic approach using siRNA-mediated depletion and automated microscopy was employed to screen for cell size-modulating CRLs in neonatal rat CM. Screening hits were confirmed by 3H-isoleucine incorporation. Of 43 targets screened, siRNA-mediated depletion of Fbxo6, Fbxo45, and Fbxl14 resulted in decreased cell size, whereas depletion of Fbxo9, Fbxo25, Fbxo30, Fbxo32, Fbxo33, Cullin1, Roc1, Ddb1, Fbxw4, and Fbxw5 led to a markedly increased cell size under basal conditions. In CM stimulated with phenylephrine (PE), depletion...
Source: Frontiers in Physiology - March 8, 2023 Category: Physiology Source Type: research