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Total 736 results found since Jan 2013.
Smooth muscle cell FTO regulates contractile function
Am J Physiol Heart Circ Physiol. 2022 Oct 28. doi: 10.1152/ajpheart.00427.2022. Online ahead of print.ABSTRACTThe Fat mass and obesity gene (FTO) is a N6-methyladenosine RNA demethylase that was initially linked by GWAS studies to increased rates of obesity. Subsequent studies have revealed multiple mass-independent effects of the gene, including cardiac myocyte contractility. We created a mouse with a conditional and inducible smooth muscle cell deletion of Fto (Myh11 Cre + Ftofl/fl) and did not observe any changes in mouse body mass or mitochondrial metabolism. However, the mice had significantly decreased blood pressure...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Melissa A Luse Nenja Kr üger Miranda E Good Lauren A Biwer Vlad Serbulea Anita Salamon Rebecca A Deaton Norbert Leitinger Axel G ödecke Brant E Isakson Source Type: research
Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts
Gen Physiol Biophys. 2022 Sep;41(5):381-392. doi: 10.4149/gpb_2022027.ABSTRACTBoth vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantly promoted the generation of ROS, MDA and 4-HNE, reduced the activities of SOD, GST and GR, increased Fe2+ concentration and inhibited GPX4 expression through circ0004372/miR-124/SERTAD4. Both UII and ferroptosis inducer Erastin significantly pro...
Source: General Physiology and Biophysics - October 12, 2022 Category: Physiology Authors: Yan-Chao Hu Tuo Han Ya-Jie Fan Chun-Yan Zhang Yan Zhang Wei-Dong Ma Cong-Xia Wang Source Type: research
