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Total 736 results found since Jan 2013.
Leonurine suppresses prostate cancer growth < em > in vitro < /em > and < em > in vivo < /em > by regulating miR-18a-5p/SLC40A1 axis
This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application.PMID:36588358 | DOI:10.4103/0304-4920.365459
Source: The Chinese Journal of Physiology - January 2, 2023 Category: Physiology Authors: Bin Liang Shouxi Cui Songnian Zou Source Type: research
ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction
In this study, we investigated the effect of acid exposure on the activation and autophagy of PSCs, and the role of ASIC1a in these events. The results showed that acidic medium upregulated the expression of ASIC1a, induced PSCs activation and autophagy, which can be suppressed by inhibiting ASIC1a using PcTx1 or ASIC1a knockdown, suggesting that ASIC1a involves these two processes. In addition, the acid-induced activation of PSCs was impaired after the application of autophagy inhibitor alone or in combination with ASIC1a siRNA, meaning a connection between autophagy and activation. Collectively, our study provides eviden...
Source: Physiological Research - December 22, 2022 Category: Physiology Authors: T Wang Q Wang G Pan G Jia X Li C Wang L Zhang C Zuo Source Type: research
The vitellogenin receptor gene is involved in lifespan regulation of Zeugodacus cucurbitae (Coquillett) after short-term high-temperature treatment
This study provides a reference to guide integrated control of Z. cucurbitae in high-temperature seasons.
Source: Frontiers in Physiology - December 22, 2022 Category: Physiology Source Type: research
Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1
Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function. Teneurins possess a bioactive peptide, termed the teneurin C-terminal associated peptide (TCAP) that interacts with the LPHNs to regulate skeletal muscle contractility strength and fatigue by an insulin-independent glucose importation mechanism in rats. CRISPR-based knockouts and siRNA-associated knockdowns of LPHN-1 and-3 in t...
Source: Frontiers in Physiology - November 29, 2022 Category: Physiology Source Type: research
Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism
In conclusion, GLUT1, -3 and -4 may all contribute to glucose uptake in differentiating osteoblasts. GLUT4 expression was clearly required for osteoblast proliferation and differentiation. GLUT1 appears to be abundant in early precursors, but stable expression of GLUT3 suggest also a role for GLUT3 in osteoblasts. Presence of other GLUT members may further contribute to fine-tuning of glucose uptake. Together, glucose uptake in osteoblast lineage appears to rely on several glucose transporters to ensure sufficient energy for new bone formation.
Source: Frontiers in Physiology - November 29, 2022 Category: Physiology Source Type: research
