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Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts
Gen Physiol Biophys. 2022 Sep;41(5):381-392. doi: 10.4149/gpb_2022027.ABSTRACTBoth vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantly promoted the generation of ROS, MDA and 4-HNE, reduced the activities of SOD, GST and GR, increased Fe2+ concentration and inhibited GPX4 expression through circ0004372/miR-124/SERTAD4. Both UII and ferroptosis inducer Erastin significantly pro...
Source: General Physiology and Biophysics - October 12, 2022 Category: Physiology Authors: Yan-Chao Hu Tuo Han Ya-Jie Fan Chun-Yan Zhang Yan Zhang Wei-Dong Ma Cong-Xia Wang Source Type: research
