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Specialty: Pathology
Therapy: Chemotherapy

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Total 17 results found since Jan 2013.

RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma < em > via < /em > JAK2/STAT3 Signaling Pathway
In this study, we investigated the role of RNF6 in RB drug resistance. Two carboplatin-resistant RB cells, Y-79/CR and SO-Rb50/CR, were generated based on Y-79 and SO-Rb50 cells. RT-PCR and western blot analyses showed that RNF6 expression on both mRNA and protein levels was significantly increased in Y-79/CR and SO-Rb50/CR cells comparing to their parental cells. Knockdown of RNF6 using siRNA in Y-79/CR and SO-Rb50/CR cells resulted in cells sensitive to carboplatin on a RNF6 siRNA dose dependent manner. Similarly, RNF6 overexpression in parental Y-79 and SO-Rb50 cells could help cells gain resistance to carboplatin on a ...
Source: Pathology Oncology Research - April 4, 2022 Category: Pathology Authors: Yong Chai Shoufeng Jiao Xin Peng Qiang Gan Leifeng Chen Xiaolu Hu Liang Hao Shouhua Zhang Qiang Tao Source Type: research

Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
AbstractSAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment before autologous stem cell transplantation for younger patients with mantle cell lymphoma (MCL). We here investigated the expression of SAMHD1 in a population-based cohort of MCL (N = 150). SAMHD1 was highly variably expre...
Source: Virchows Archiv - November 4, 2021 Category: Pathology Source Type: research

Down-regulation of FOS-like antigen 1 enhances drug sensitivity in breast cancer.
CONCLUSION: Down-regulation of FOSL1 potentiated chemotherapy sensitivity of breast cancer, and its lower expression attenuated chemotherapeutic drug resistance in human breast cancer cells. FOSL1 might be a drug target for predicting chemotherapy effect in breast cancer. PMID: 32922605 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Duan L, Zhao M, Ang L, Hu H, Wu Z, Wang J, Huang J, Zheng L, Dong W Tags: Int J Clin Exp Pathol Source Type: research

ZEB1 mediates doxorubicin (Dox) resistance and mesenchymal characteristics of hepatocarcinoma cells.
Abstract The acquired chemoresistance during long term chemotherapy is one of the most important factors to limit the application of Doxorubicin (Dox) on clinical treatment of hepatocellular carcinoma (HCC) patients. Our present study found that Dox resistant HCC (HCC/Dox) cells had greater capability of in vitro migration and invasion compared to their parental cells. HCC/Dox cells exhibited mesenchymal characteristics, which was evidenced by the up regulation of fibronectin, vimentin while down regulation of E-Cadherin. Zeb1, one powerful epithelial mesenchymal transition related transcription factor (EMT-TF), w...
Source: Experimental and Molecular Pathology - January 4, 2019 Category: Pathology Authors: Long L, Xiang H, Liu J, Zhang Z, Sun L Tags: Exp Mol Pathol Source Type: research

Knockdown of PINCH-1 protein sensitizes the Estrogen positive breast cancer cells to chemotherapy induced apoptosis
Conclusion The results suggest that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer. However, enhanced apoptosis observed only in estrogen positive and not in estrogen negative cells upon PINCH-1 knockdown point towards participation of some other protein with redundant functions in the later subtype which needs to be investigated.
Source: Pathology Research and Practice - September 30, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma.
Abstract Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or western blot assay was performed to analyze FOXP3 expression in A549 cells. Cell proliferation and cisplatin cytotoxicity test were assessed by CCK-8 assay. The expression...
Source: Pathology, Research and Practice - September 8, 2017 Category: Pathology Authors: Li C, Sun L, Jiang R, Wang P, Xue H, Zhan Y, Gai X Tags: Pathol Res Pract Source Type: research

Overexpression of HIF1 α and CAXI predicts poor outcome in early-stage triple negative breast cancer
AbstractDysregulated energy metabolism is one of the main mechanisms for uncontrolled growth in solid tumors. Hypoxia-inducible factor 1-alpha (HIF1 α) is a transcription factor implicated in regulating several genes that are responsible for cell metabolism, including carbonic anhydrase IX (CAIX). The aim of this study is to determine the clinical significance of immunohistochemical metabolic alteration in early-stage triple negative breast can cer (TNBC) patients who received cyclophosphamide-based chemotherapy or radiotherapy and those with basal phenotype. Immunohistochemical staining for HIF1α and CAIX was performed ...
Source: Virchows Archiv - July 31, 2016 Category: Pathology Source Type: research

Overexpression of HIF1α and CAXI predicts poor outcome in early-stage triple negative breast cancer
Abstract Dysregulated energy metabolism is one of the main mechanisms for uncontrolled growth in solid tumors. Hypoxia-inducible factor 1-alpha (HIF1α) is a transcription factor implicated in regulating several genes that are responsible for cell metabolism, including carbonic anhydrase IX (CAIX). The aim of this study is to determine the clinical significance of immunohistochemical metabolic alteration in early-stage triple negative breast cancer (TNBC) patients who received cyclophosphamide-based chemotherapy or radiotherapy and those with basal phenotype. Immunohistochemical staining for HIF1α and CAIX was pe...
Source: Virchows Archiv - May 15, 2016 Category: Pathology Source Type: research

Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy.
We describe the safety and toxicity studies with siG12D-LODER in 192 Hsd:Sprague Dawley rats, after repeated subcutaneous administrations (days 1, 14, and 28). Animals were sacrificed on days 29 and 42 (recovery phase). In all groups, no adverse effects were noted, and all animals showed favorable local and systemic tolerability. Histopathologically, LODER implantation resulted in the expected capsule formation, composed of a thin fibrotic tissue. On the interface between the cavity and the capsule, a single layer composed of macrophages and multinucleated giant cells was observed. No difference was noted between the place...
Source: Toxicologic Pathology - May 3, 2016 Category: Pathology Authors: Ramot Y, Rotkopf S, Gabai RM, Khvalevsky EZ, Muravnik S, Marzoli GA, Domb AJ, Shemi A, Nyska A Tags: Toxicol Pathol Source Type: research

Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells.
Abstract Stress granules are small RNA-protein granules that modify the translational landscape during cellular stress to promote survival. The RhoGTPase RhoA is implicated in the formation of RNA stress granules. Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma cells. AurkB and its downstream target histone-3 are phosphorylated during arsenite-induced stress. Chemical (AZD1152-HQPA) and siRNA inhibition of AurkB results in fewer and smaller stress granules when analyzed using high-throughput fluoresc...
Source: The American Journal of Pathology - April 19, 2016 Category: Pathology Authors: Weeks A, Agnihotri S, Lymer J, Chalil A, Diaz R, Isik S, Smith C, Rutka JT Tags: Am J Pathol Source Type: research

MiR-136 modulates glioma cell sensitivity to temozolomide by targeting astrocyte elevated gene-1
Conclusions: The present study provides the first evidence that miR-136 plays a key role in TMZ resistance by targeting the AEG-1 protein in glioma cell line, suggesting that miR-136 can be used to predict a patient?s response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_173
Source: Diagnostic Pathology - September 30, 2014 Category: Pathology Authors: Hao WuQiang LiuTao CaiYu-dan ChenFan LiaoZhi-fei Wang Source Type: research

Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.
CONCLUSIONS: Nrf2-activated autophagy may function as a novel mechanism causing cisplatin-resistance. PMID: 24817946 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Bao LJ, Jaramillo MC, Zhang ZB, Zheng YX, Yao M, Zhang DD, Yi XF Tags: Int J Clin Exp Pathol Source Type: research