Knockdown of PINCH-1 protein sensitizes the Estrogen positive breast cancer cells to chemotherapy induced apoptosis

Conclusion The results suggest that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer. However, enhanced apoptosis observed only in estrogen positive and not in estrogen negative cells upon PINCH-1 knockdown point towards participation of some other protein with redundant functions in the later subtype which needs to be investigated.
Source: Pathology Research and Practice - Category: Pathology Source Type: research