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Total 681 results found since Jan 2013.
Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome
Toxoplasma gondii infection in pregnant women may cause fetal anomaly; however, the underlying mechanisms remain unclear. Here, we investigated whether T. gondii induces pyroptosis in human placental cells and the underlying mechanisms. Human placental trophoblast (BeWo and HTR-8/SVneo) and amniotic (WISH) cells were infected with T. gondii, and then ROS production, cathepsin B (CatB) release, inflammasome activation, and pyroptosis induction were evaluated. Moreover, the molecular mechanisms of these effects were investigated by treating the cells with ROS scavengers, a CatB inhibitor, or inflammasome-specific siRNA.
Source: American Journal of Pathology - September 21, 2023 Category: Pathology Authors: Juan-Hua Quan, Fei Fei Gao, Tian-Zhong Ma, Wei Ye, Xiang Gao, Ming-Zhu Deng, Lan-Lan Yin, In-Wook Choi, Jae-Min Yuk, Guang-Ho Cha, Young-Ha Lee, Jia-Qi Chu Tags: Regular Article Source Type: research
Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines
CONCLUSIONS: LINC00941 is overexpressed in GBM, exhibiting important roles in cell proliferation and survival, migration and invasion.PMID:37587895 | DOI:10.5114/fn.2023.126894
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Yuan Wang Shuwei Wang Haibo Wang Di Zhao Haoliang Zhang Huan Liu Jianzhong Cui Kaijie Wang Source Type: research
