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Specialty: Laboratory Medicine
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Total 432 results found since Jan 2013.
High nuclear expression of APE1 correlates with unfavorable prognosis and promotes tumor growth in hepatocellular carcinoma
In this study, bioinformatics analysis of APE1 was performed in several databases, including the TCGA, GeneCard, Human Protein Atlas and Ualcan databases. The relationship between APE1 mRNA expression and several attributes of liver cancer patients in TCGA was investigated. Then, the protein expression of APE1 was detected by IHC analysis in 95 HCC samples and the association between APE1 expression and the clinicopathological parameters of HCC patients was explored. GSEA-KEGG analysis was performed to predict the potential signaling pathways that associated with APE1 expression. Then the siRNA-mediated knockdown model of ...
Source: Journal of Molecular Histology - January 4, 2021 Category: Laboratory Medicine Source Type: research
Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?
AbstractPurpose of ReviewUlcerative colitis (UC) is a chronic inflammatory bowel disorder that causes inflammation in the colon and rectum and can be lethal to the patients. The dysbiotic intestinal microbiome is considered a major factor of UC, yet it needs more evidences. As there is no cure for UC, anti-inflammatory drugs, potent steroids, immunomodulatory drugs, or even surgery is used to manage the disease. The purpose of this review is to focus on the underlying factors involved in the disease pathogenicity, including host gut microbiome and novel therapies for treatment of UC.Recent FindingsDue to disruption of inte...
Source: Current Pathobiology Reports - January 6, 2021 Category: Laboratory Medicine Source Type: research
RHBDD1 silencing inhibited cell growth and invasion of non-small cell lung cancer by mediating ZEB1/PI3K/AKT signaling pathway
In this study, we aimed to investigate the role of RHBDD1 and its underlying molecular mechanism in NSCLC. The gene RHBDD1 expression was detected in NSCLC tissues and matched nontumor adjacent tissues. In vitro experiments, NSCLC cell lines (A549, H1650, H358 and H1299) were performed to investigate the biological function of RHBDD1 and its molecular mechanism. Our findings showed that the mRNA and protein expression levels of RHBDD1 were notably increased in human NSCLC tissues and cell lines, especially in A549 and H1650 cells. Moreover, silencing of RHBDD1 by RNAi notably inhibited NSCLC cell proliferation and increase...
Source: Journal of Molecular Histology - January 29, 2021 Category: Laboratory Medicine Source Type: research
The Role, Function, and Mechanism of Long Intergenic Noncoding RNA1184 (linc01184) in Colorectal Cancer.
Conclusions: The findings reveal for the first time that linc01184 is an enhancer for the proliferation and invasion of CRC by functioning as a ceRNA through the linc01184-miR-331-HER2-p-Akt/ERK1/2 pathway regulatory network.
PMID: 33564344 [PubMed - in process]
Source: Disease Markers - February 12, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.PMID:33334789
Source: Annals of Clinical and Laboratory Science - December 18, 2020 Category: Laboratory Medicine Authors: Zhengming Yang Jianjun Qian Wei Yu Minfei Yang Bin Liu Huimin Tao Source Type: research
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling
This study aimed to explore the role of Toll-like receptors 2 (TLR2) in Ang II-induced cardiac remodeling. We investigated the effect of TLR2 deficiency on Ang II-induced cardiac remodeling by utilizing TLR2 knockout mice, bone marrow transplantation models, and H9C2 cells. Though TLR2 deficiency had no effect on body weight change, cardiac Ang II content and blood pressure, it significantly ameliorated cardiac hypertrophy, fibrosis and inflammation, as well as improved heart function. Further bone marrow transplantation studies showed that TLR2-deficiency in cardiac cells but not bone marrow-derived cells prevented Ang II...
Source: Translational Research : the journal of laboratory and clinical medicine - March 2, 2021 Category: Laboratory Medicine Authors: Shiju Ye Ke Lin Gaojun Wu Ming-Jiang Xu Peiren Shan Weijian Huang Yi Wang Guang Liang Source Type: research
Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.PMID:33334789
Source: Annals of Clinical and Laboratory Science - December 18, 2020 Category: Laboratory Medicine Authors: Zhengming Yang Jianjun Qian Wei Yu Minfei Yang Bin Liu Huimin Tao Source Type: research
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling
This study aimed to explore the role of Toll-like receptors 2 (TLR2) in Ang II-induced cardiac remodeling. We investigated the effect of TLR2 deficiency on Ang II-induced cardiac remodeling by utilizing TLR2 knockout mice, bone marrow transplantation models, and H9C2 cells. Though TLR2 deficiency had no effect on body weight change, cardiac Ang II content and blood pressure, it significantly ameliorated cardiac hypertrophy, fibrosis and inflammation, as well as improved heart function. Further bone marrow transplantation studies showed that TLR2-deficiency in cardiac cells but not bone marrow-derived cells prevented Ang II...
Source: Translational Research : the journal of laboratory and clinical medicine - March 2, 2021 Category: Laboratory Medicine Authors: Shiju Ye Ke Lin Gaojun Wu Ming-Jiang Xu Peiren Shan Weijian Huang Yi Wang Guang Liang Source Type: research
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension
Transl Res. 2021 Mar 7:S1931-5244(21)00054-2. doi: 10.1016/j.trsl.2021.03.004. Online ahead of print.ABSTRACTOphiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert anti-proliferative and anti-tissue remodeling effects. Vascular remodeling and vasoconstriction play critical roles in the development of pulmonary hypertension (PH). The therapeutic potential of OCS for PH was investigated using rodent PH models, and cultured pulmonary artery endothelial and smooth muscle cells (PAECs and PASMCs), with a focus on the involvement of TRPM7. OCS ameliorated the development of PH, right ventricular hypertrophy...
Source: Translational Research : the journal of laboratory and clinical medicine - March 10, 2021 Category: Laboratory Medicine Authors: Keizo Hiraishi Lin Hai Kurahara Jianlin Feng Aya Yamamura Yuanyuan Cui Eiji Yahiro Hiroyasu Yokomise Tetsuhiko Go Kaori Ishikawa Naoya Yokota Atsushi Fujiwara Miki Onitsuka Kohtaro Abe Shoji Ohga Toru Satoh Yasumasa Okada Lixia Yue Ryuji Inoue Katsuya Hir Source Type: research
