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Specialty: Laboratory Medicine
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Total 432 results found since Jan 2013.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression
Transl Res. 2023 Apr 29:S1931-5244(23)00072-5. doi: 10.1016/j.trsl.2023.04.005. Online ahead of print.ABSTRACTAberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined. Here we reported that selective METTL3 (methyltransferase like 3) elevation and the consequential increase of m6A modification causally affect OS progression. The fast-growing OS cells displayed preferential upregulation of METTL3 and increased m6A modification. Conversely, m6A inhibition by 3-deazaadenosine, siRNA-medi...
Source: Translational Research : the journal of laboratory and clinical medicine - April 30, 2023 Category: Laboratory Medicine Authors: Xueying An Wenshu Wu Lin Yang Jian Dong Bin Liu Junxia Guo Jianmei Chen Baosheng Guo Wangsen Cao Qing Jiang Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research
PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis
& Didier Merlin
Source: Laboratory Investigation AOP - June 24, 2013 Category: Laboratory Medicine Authors: Saravanan AyyaduraiMoiz A CharaniaBo XiaoEmilie ViennoisDidier Merlin Tags: inflammation PepT1 KO siRNA Source Type: research
Ex vivo evaluation of antifibrotic compounds in skin scarring: EGCG and silencing of PAI-1 independently inhibit growth and induce keloid shrinkage
& Ardeshir Bayat
Source: Laboratory Investigation AOP - July 8, 2013 Category: Laboratory Medicine Authors: Farhatullah SyedRania A BagabirRalf PausArdeshir Bayat Tags: dexamethasone EGCG immunohistochemistry keloid organ culture PAI-1 siRNA Source Type: research
A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization
aka
& Takayuki Asahara
Source: Laboratory Investigation AOP - July 29, 2013 Category: Laboratory Medicine Authors: Yohei KawakamiMasaaki IiTomoyuki MatsumotoAtsuhiko KawamotoRyosuke KurodaHiroshi AkimaruYutaka MifuneTaro ShojiTomoaki FukuiMichio AsahiMasahiro KurosakaTakayuki Asahara Tags: angiogenesis endothelial progenitor cells fracture healing Lnk siRNA Source Type: research
The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2
In this study, human HCC as well as adjacent noncancerous tissues, together with three kinds of liver cancer cell lines were investigated to clarify the possible involvement of CXCL9 in the regulation of HCC invasion and metastasis. Invasion ability of liver cancer cells were evaluated by transwell assays and it is enhanced after co-cultured with recombined human CXCL9 (rhCXCL9). As a trigger of Rac GTPase signaling after G protein-coupled receptors (GPCR) activated by CXCL9, Phosphatidylinositol-3, 4, 5-trisphosphate RAC Exchanger 2 (PREX2) mRNA expression of the liver cancer cell lines was elevated after co-cultured with...
Source: Journal of Molecular Histology - November 20, 2014 Category: Laboratory Medicine Source Type: research
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma
In this study, we investigated the expression pattern of UBE2Q1 in HCC cell lines and human HCC specimens, and its potential clinical and biological significance in HCC. Western blot and immunohistochemical analyses revealed that UBE2Q1 was significantly upregulated in HCC tumorous tissues compared with the adjacent noncancerous ones. Next, univariate and multivariate survival analyses were performed to determine the prognostic significance of UBE2Q1 in HCC. The results showed that upregulated expression of UBE2Q1 was positively correlated with high histological grades of HCC and predicted poor prognosis. In addition, the ...
Source: Journal of Molecular Histology - October 14, 2014 Category: Laboratory Medicine Source Type: research
Overexpression of PSF1 is correlated with poor prognosis in hepatocellular carcinoma patients.
CONCLUSIONS: These results suggest that the inhibition of PSF1 might provide new therapeutic approaches for HCC.
PMID: 25198552 [PubMed - as supplied by publisher]
Source: International Journal of Biological Markers - December 1, 2014 Category: Laboratory Medicine Tags: Int J Biol Markers Source Type: research
Humoral immune response against tumoral mucin 1 (MUC1) in breast cancer patients.
Authors: Isla Larrain MT, Colussi AG, Demichelis SO, Barbera A, Cretón A, Segal-Eiras A, Croce MV
Abstract
The aim of this study was to elucidate whether the IgG humoral immune response to breast cancer cells is directed to the aberrant mucin-1 (MUC1) associated to this type of cancer. To this aim, an adaptation of immunohistochemistry (IHC) was performed on samples of 45 breast cancer tissues, 12 benign disease tissues, and 31 normal tissues, incubated with matched serum samples from the same patients. Each serum sample was also incubated, with a modified immunocytochemistry (ICC), with MCF7 cells. In both techni...
Source: International Journal of Biological Markers - December 1, 2014 Category: Laboratory Medicine Tags: Int J Biol Markers Source Type: research
αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer.
In this study, we investigated whether αB-crystallin expression is correlated to pERK1/2 expression in breast cancer. In a balanced tissue microarray the expression of αB-crystallin and pERK1/2 kinase were determined immunohistochemically, together with the triple-negativity and basal-like markers CK5/6 and SMA and the signaling molecules pAKT, pmTOR, EGFR, and IGF-1R. αB-crystallin expression significantly correlated with triple negativity and basal-like markers CK5/6 and SMA (Pearson Chi-square test p=0.004, p=0.001, and p<0.001, respectively). A significant correlation was also observed with pERK1/2 expression...
Source: International Journal of Biological Markers - December 1, 2014 Category: Laboratory Medicine Tags: Int J Biol Markers Source Type: research
Expression and clinical role of TCTP in epithelial ovarian cancer
Abstract
The aim of this study is to investigate the potential role and prognostic significance of translationally controlled tumor protein (TCTP) in human epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of TCTP in eight fresh EOC tissues. Immunohistochemistry was performed on formalin-fixed paraffin-embedded sections of 119 cases of ovarian cancers. Kaplan–Meier method indicated the relation between TCTP and EOC patients’ overall survival rate. Starvation and re-feeding was used to assess cell cycle. Knocking down of TCTP and CCK8 assay showed the role of TCTP in HO8910 cell ...
Source: Journal of Molecular Histology - January 7, 2015 Category: Laboratory Medicine Source Type: research
Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model.
Conclusions. Targeted blockade of AQP1 restricts MM growth and migration in vitro. Further work is warranted to fully evaluate treatment potential in vivo.
PMID: 25821338 [PubMed - in process]
Source: Disease Markers - April 1, 2015 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide
Abstract
Proteasomes are major intracellular extralysosomal organelle for protein degradation and a central source of antigenic peptides in the endogenous pathway. Proteasome beta-4 subunit (PSMB4) was recently identified as potential cancer driver genes in several tumors. However, information regarding its regulation and possible function in the central nervous system is still limited. The present study was designed to elucidate dynamic changes in PSMB4 expression and distribution in the cerebral cortex in a lipopolysaccharide (LPS)-induced neuroinflammation rat model. It was found that PSMB4 expression was incre...
Source: Journal of Molecular Histology - August 18, 2015 Category: Laboratory Medicine Source Type: research
