Filtered By:
Specialty: Laboratory Medicine
This page shows you your search results in order of relevance. This is page number 11.
Order by Relevance | Date
Total 432 results found since Jan 2013.
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension
Transl Res. 2021 Mar 7:S1931-5244(21)00054-2. doi: 10.1016/j.trsl.2021.03.004. Online ahead of print.ABSTRACTOphiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert anti-proliferative and anti-tissue remodeling effects. Vascular remodeling and vasoconstriction play critical roles in the development of pulmonary hypertension (PH). The therapeutic potential of OCS for PH was investigated using rodent PH models, and cultured pulmonary artery endothelial and smooth muscle cells (PAECs and PASMCs), with a focus on the involvement of TRPM7. OCS ameliorated the development of PH, right ventricular hypertrophy...
Source: Translational Research : the journal of laboratory and clinical medicine - March 10, 2021 Category: Laboratory Medicine Authors: Keizo Hiraishi Lin Hai Kurahara Jianlin Feng Aya Yamamura Yuanyuan Cui Eiji Yahiro Hiroyasu Yokomise Tetsuhiko Go Kaori Ishikawa Naoya Yokota Atsushi Fujiwara Miki Onitsuka Kohtaro Abe Shoji Ohga Toru Satoh Yasumasa Okada Lixia Yue Ryuji Inoue Katsuya Hir Source Type: research
Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells
In conclusion, ENG deficiency alters the VEGF/VEGFR2 pathway, which may play a role in HHT pathogenesis.PMID:33894400 | DOI:10.1016/j.trsl.2021.04.005
Source: Translational Research : the journal of laboratory and clinical medicine - April 24, 2021 Category: Laboratory Medicine Authors: Qiuwang Zhang Chenxi Wang Anthony Cannavicci Marie E Faughnan Michael J B Kutryk Source Type: research
PLAC1 Regulates the Occurrence of Fetal Growth Restriction by Inhibiting the Apoptosis of Trophoblast Cells
CONCLUSION: The expression of PLAC1 was reduced in fetal growth restriction and did not protect trophoblast cells from hypoxic damage, suggesting that PLAC1 may be an important regulator in the occurrence of fetal growth restriction.PMID:33941557
Source: Annals of Clinical and Laboratory Science - May 4, 2021 Category: Laboratory Medicine Authors: Dandan Sun Hanbing Wu Zepeng Ping Hui Zhu Ling Ai Source Type: research
