Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells

In conclusion, ENG deficiency alters the VEGF/VEGFR2 pathway, which may play a role in HHT pathogenesis.PMID:33894400 | DOI:10.1016/j.trsl.2021.04.005

Source: Translational Research : the journal of laboratory and clinical medicine - April 24, 2021 Category: Laboratory Medicine Authors: Qiuwang Zhang Chenxi Wang Anthony Cannavicci Marie E Faughnan Michael J B Kutryk Source Type: research