Hereditary Hemorrhagic Telangiectasia News This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
Mayo Clinic goes off-label to treat severe bleeding disorder
For people with a rare bleeding disorder called "hereditary hemorrhagic telangiectasia," or HHT, simple issues such as a nosebleed can be life-threatening. The disease has no cure. But Dr. Vivek Iyer, a Mayo Clinic pulmonary and critical care physician, found that a drug commonly used for cancer can stop the bleeding and restore quality of [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 26, 2019 Category: Databases & Libraries Source Type: news
IV Bevacizumab Effective for Severe HHT - Related Bleeding
Drop in RBC transfusion requirements, epistaxis severity in hereditary hemorrhagic telangiectasia (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 5, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pharmacy, Journal, Source Type: news
Bevacizumab dramatically improves severe hereditary hemorrhagic telangiectasia (HHT) associated bleeding
(Elsevier) Patients with hereditary hemorrhagic telangiectasia (HHT) with severe bleeding, who were treated with intravenous bevacizumab, reported a marked reduction in nose bleeds and gastrointestinal bleeding and were able to stop or considerably reduce blood transfusions, resulting in significantly improved quality of life. A new study published in Mayo Clinic Proceedings provides good quality evidence for the excellent safety profile and efficacy of intravenous bevacizumab in the management of these patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 29, 2018 Category: International Medicine & Public Health Source Type: news
Should I Worry About This Telangiectasia?
Discussion Vascular stains are common problems that parents seek guidance about as they are often particularly worried that there may be an underlying problem or that it may be a long-term cosmetic problem. Fortunately many resolve or become less prominent or have treatment available. The term vascular stains includes all vascular malformations but commonly refers more directly to capillary malformations which are quite common. Some common vascular stains include: Nevus simplex Names: Angel’s kiss (glabella or forehead), salmon patch, stork bite (nape of neck), nevus roseus, fading macular stain Epidemiology: Very ...
Source: PediatricEducation.org - January 29, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia
We report that mice lacking Drosha in the vascular endothelium developed a vascular phenotype resembling HHT that included dilated and disorganized vasculature, arteriovenous fistulae, and hemorrhages. Exome sequencing of HHT patients who lacked known pathogenic mutations revealed an overrepresentation of rare nonsynonymous variants of DROSHA. Two of these DROSHA variants (P100L and R279L) did not interact with Smads and were partially catalytically active. In zebrafish, expression of these mutants or morpholino-directed knockdown of Drosha resulted in angiogenesis defects and abnormal vascular permeability. Together, our ...
Source: Signal Transduction Knowledge Environment - January 16, 2018 Category: Science Authors: Jiang, X., Wooderchak-Donahue, W. L., McDonald, J., Ghatpande, P., Baalbaki, M., Sandoval, M., Hart, D., Clay, H., Coughlin, S., Lagna, G., Bayrak-Toydemir, P., Hata, A. Tags: STKE Research Articles Source Type: news
Iron tablets may damage DNA
Conclusion This study showed that iron can induce a DNA damage response at a genetic level in isolated human endothelial cells in the laboratory. The study was early stage and packed with limitations and questions needing answers through further research. So it is not close to the stage where doctors need to change their approach to prescribing iron supplements. Similarly, this study is no reason to stop taking iron medication as prescribed, and stopping could be harmful. Keep calm and carry on. The fact iron causes a DNA repair response does not necessarily mean it causes damage or disease. It may stress the cell out, bu...
Source: NHS News Feed - February 12, 2016 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news
June is Hereditary Hemorrhagic Telangiectasia Awareness Month
(Source: St. Michael's Hospital News and Media)
Source: St. Michael's Hospital News and Media - June 23, 2013 Category: Hospital Management Tags: Hospital News Source Type: news