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Specialty: Laboratory Medicine
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Total 432 results found since Jan 2013.
Inhibition of HIF-1α Affects Autophagy Mediated Glycosylation in Oral Squamous Cell Carcinoma Cells.
Conclusions. Autophagy reduced by hypoxic stress inhibited. HIF-1α inhibitor decreased glycosylation. OGT became unstable in the absence of autophagy when HIF-1α signaling was blocked.
PMID: 26640316 [PubMed - in process]
Source: Disease Markers - December 11, 2015 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Downregulated Smad4 Affects Extracellular Matrix Remodeling in Ventilator-induced Lung Injury.
CONCLUSION: Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.
PMID: 27650609 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - August 31, 2016 Category: Laboratory Medicine Authors: Huang X, Zhou W, Ding S Tags: Ann Clin Lab Sci Source Type: research
EZH2 Downregulation Augments the Effect of Irradiation in Reducing Pancreatic Cancer Cell Proliferation in vitro.
CONCLUSIONS: EZH2 downregulation in combination with irradiation reduces PANC-1 and MIA PaCa-2 cell proliferation more than irradiation alone. This study affirms the role of EZH2 downregulation for radiosensitization in pancreatic cancer treatment.
PMID: 32161011 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - December 31, 2019 Category: Laboratory Medicine Authors: Agrawal R, Chen M, Bukhari Z, Ogunwobi OO, Haseeb MA, Martello LA Tags: Ann Clin Lab Sci Source Type: research
Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3 β/β-catenin pathway
AbstractThe apoptosis of mature osteocytes is the main factor causing damage to the microstructure of cortical bone in glucocorticoid-induced osteoporosis (GIOP). Our previous research found damaged areas and empty osteocytes lacunae in the tibial cortical bone of GIOP mice. However, the specific mechanism has not been clarified. Recently, a study showed that the quality of the cortical bone significantly increased by knocking out Notum, a gene encoding α/β hydrolase. However, it is not clear whether Notum affects cortical bone remodeling by participating in glucocorticoids (GCs)-induced apoptosis of osteocytes. The pres...
Source: Journal of Molecular Histology - July 23, 2021 Category: Laboratory Medicine Source Type: research
Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21 –ACE2 signaling
This study aims to explore regulatory roles and underlying mechanisms of ELA in rat aortic adventitial fibroblasts (AFs) in response to angiotensin II (ATII). In cultured AFs, exposure to ATII resulted in marked decreases in mRNA and protein levels of ELA, fibroblast growth factor 21 (FGF21), and angiotensin-converting enzyme 2 (ACE2) as well as increases in apoptosis, inflammation, oxidative stress, and cellular migration, which were partially blocked by the exogenous replenishment of ELA and recombinant FGF21, respectively. Moreover, treatment with ELA strikingly reversed ATII-mediated the loss of FGF21 and ACE2 level...
Source: Journal of Molecular Histology - August 28, 2021 Category: Laboratory Medicine Source Type: research
Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research
