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Condition: Hypertension

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Total 587 results found since Jan 2013.

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II – induced hypothalamic reactive oxygen species and hypertension
Publication date: 4 August 2016 Source:Neuroscience, Volume 329 Author(s): Hong-Wei Wang, Bing S. Huang, Roselyn A. White, Aidong Chen, Monir Ahmad, Frans H.H. Leenen Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to downstream nuclei such as the paraventricular nucleus (PVN), supraoptic nucleus (SON) and rostral ventrolateral medulla (RVLM). In Wist...
Source: Neuroscience - May 20, 2016 Category: Neuroscience Source Type: research

Downregulation of Renal G Protein-Coupled Receptor Kinase Type 4 Expression via Ultrasound-Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats Hypertension
ConclusionsTaken together, these study results indicate that UTMD‐targeted GRK4 siRNA delivery to the kidney effectively reduces D1R phosphorylation by inhibiting renal GRK4 expression, improving D1R‐mediated natriuresis and diuresis, and lowering BP, which may provide a promising novel strategy for gene therapy for hypertension.
Source: JAHA:Journal of the American Heart Association - October 5, 2016 Category: Cardiology Authors: Huang, H., Li, X., Zheng, S., Chen, Y., Chen, C., Wang, J., Tong, H., Zhou, L., Yang, J., Zeng, C. Tags: Nephrology and Kidney, High Blood Pressure, Hypertension Original Research Source Type: research

Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression.
Conclusions: The expression of the C9 gene in cultured RPE cells is highly induced by extracellular hyperosmolarity, hypoxia, and oxidative stress. The data may support the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in RPE cells. Extracellular C9 protein may attenuate this effect, in part via negative regulation of the C9 mRNA level. PMID: 30090015 [PubMed - in process]
Source: Molecular Vision - August 11, 2018 Category: Molecular Biology Tags: Mol Vis Source Type: research

Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration
Vascul Pharmacol. 2021 Mar 29:106860. doi: 10.1016/j.vph.2021.106860. Online ahead of print.ABSTRACT5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporter and receptors plays important roles in chronic hypoxic pulmonary hypertension (CHPH), which is associated with aberrant reactive oxygen species (ROS) production. NADPH oxidase 4 (NOX4) is one of the major sources of ROS in pulmonary vasculature, and has been implicated in the development of PH. NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and ...
Source: Vascular Pharmacology - April 1, 2021 Category: Drugs & Pharmacology Authors: Jia-Lin Song Si-Yi Zheng Rui-Lan He Long-Xin Gui Mo-Jun Lin James S K Sham Source Type: research

Silencing of Fli1 gene mimics effects of preeclampsia and induces collagen synthesis in human umbilical arteries
CONCLUSIONS: Our results show that after silencing the Fli1 gene in healthy human umbilical arteries a new phenotype emerges which is typical for preeclampsia and is associated with vascular fibrosis.PMID:35569064 | DOI:10.1093/ajh/hpac065
Source: American Journal of Hypertension - May 15, 2022 Category: Cardiology Authors: Natalia I Agalakova Vitaly A Reznik Ivan A Ershov Ekaterina A Lupanova Olga V Nadei Dmitry O Ivanov C David Adair Alexei Y Bagrov Source Type: research

Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation.
Abstract Eukaryotic elongation factor (eEF) 2 kinase (eEF2K) is a Ca(2+)/calmodulin-dependent protein kinase. We recently demonstrated that eEF2K protein increases in mesenteric artery from spontaneously hypertensive rats (SHR). Pathogenesis of hypertension is regulated in part by vascular inflammation. We tested the hypothesis whether eEF2K mediates vascular inflammatory responses and development of hypertension. In vascular endothelial cells, small interfering RNA (siRNA) against eEF2K inhibited induction of vascular cell adhesion molecule (VCAM)-1 and endothelial-selectin as well as monocyte adhesion by tumor n...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 28, 2013 Category: Physiology Authors: Usui T, Okada M, Hara Y, Yamawaki H Tags: Am J Physiol Heart Circ Physiol Source Type: research

Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation
Eukaryotic elongation factor 2 kinase (eEF2K) is a Ca2+/calmodulin-dependent protein kinase. We recently demonstrated that eEF2K protein increases in mesenteric artery from spontaneously hypertensive rats (SHR). Pathogenesis of hypertension is regulated in part by vascular inflammation. We tested the hypothesis whether eEF2K mediates vascular inflammatory responses and development of hypertension. In vascular endothelial cells, small interfering RNA (siRNA) against eEF2K inhibited induction of VCAM-1 and endothelial-selectin as well as monocyte adhesion by TNF-α (10 ng/ml). eEF2K siRNA inhibited phosphorylation of JN...
Source: AJP: Heart and Circulatory Physiology - September 1, 2013 Category: Cardiology Authors: Usui, T., Okada, M., Hara, Y., Yamawaki, H. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

Abstract 22: Histone Deacetylase (HDAC) 4 Controls Neointimal Hyperplasia via Stimulating Proliferation and Migration of Vascular Smooth Muscle Cells Oral Session II: Concurrent B Vascular Biology
Histone deacetylases (HDACs) are transcriptional co-regulators. We have recently demonstrated that a class IIa HDAC, HDAC4 promotes reactive oxygen species (ROS)-dependent vascular smooth muscle inflammation and mediates the development of hypertension in spontaneously hypertensive rats. Pathogenesis of hypertension is in part modulated by vascular structural remodeling via proliferation and migration of vascular smooth muscle cells (SMCs). We thus examined whether HDAC4 controls SMCs proliferation and migration. In rat mesenteric arterial SMCs, small interfering RNA (siRNA) against HDAC4 inhibited platelet-derived growth ...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Usui, T., Okada, M., Yamawaki, H. Tags: Oral Session II: Concurrent B Vascular Biology Source Type: research

Abstract 52: Human Grk4{gamma}142v, Via Histone Deacetylase 1, Produces At1r-dependent Hypertension Oral Session VII: Concurrent A Clinical Issues
Human gene variants account for only a small proportion of essential hypertension in humans and have not been shown to produce hypertension in transgenic mice. The association between hypertension and 11 allelic variants of 8 candidate genes in humans (n=1074) was studied. We also evaluated the response to angiotensin receptor blockers (ARBs) in humans (n=681) and transgenic mice generated to express the human wild-type G protein-coupled receptor kinase 4 (hGRK4WT) or the 142V allele (hGRK4142V). hGRK4 variants (R65L, A142V, and A486V) were associated with essential hypertension; hGRK4142V, by itself, predicted the hyperte...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Jose, P., Wang, Z., Sanada, H., Yoneda, M., Zheng, C., Williams, S., Bartlett, J., White, M., Gordon, L., Liu, M., Konkalmatt, P., Wang, X., Asico, L., Villar, V. A., Jones, J., Armando, I., Felder, R., Eisner, G. Tags: Oral Session VII: Concurrent A Clinical Issues Source Type: research

Abstract 441: Aldosterone-salt Hypertension Depends on the SFO, Central Aldosterone Synthase and MR Specifically in the PVN Poster Session II
We examined the role of the subfornical organ (SFO), aldo synthesized locally in the brain, and MR specifically in the paraventricular nucleus (PVN) in aldo-salt hypertension. Wistar rats with telemetry probes were treated with chronic intra-cerebroventricular infusion of aldo synthase (AS) inhibitor FAD286 (25 μg/day), MR blocker eplerenone (5 μg/day) or vehicle. After 2 days, subcutaneous (sc) aldo infusion (1 μg/h) was started and saline was provided as drinking water. In a second set of rats with telemetry, electrolytic or sham lesions of the SFO, or bilateral intra-PVN infusion of AAV-MR-siRNA or AAV-SCM-siRN...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Huang, B. S., Ahmad, M., Chen, A., White, R. A., Leenen, F. H., Leenen, F. H. Tags: Poster Session II Source Type: research

Endothelin-1 decreases Endothelial PPAR gamma Signaling and Impairs Angiogenesis After Chronic Intrauterine Pulmonary Hypertension.
Abstract Increased endothelin-1 (ET-1) disrupts angiogenesis in persistent pulmonary hypertension of the newborn (PPHN), but pathogenic mechanisms are unclear. PPAR gamma (PPARγ) is decreased in adult pulmonary hypertension, but whether ET-1-PPARγ interactions impair endothelial cell (EC) function and angiogenesis in PPHN remains unknown. We hypothesized that increased PPHN PAEC ET-1 production decreases PPARγ signaling and impairs tube formation in vitro. Proximal PAECs were harvested from fetal sheep after partial ligation of the ductus arteriosus in utero (PPHN) and controls. PPARγ and phospho-PPARγ protei...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 13, 2013 Category: Cytology Authors: Wolf D, Tseng N, Seedorf GJ, Roe GB, Abman SH, Gien J Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research