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Total 77 results found since Jan 2013.
Role of (Pro)Renin Receptor in Cyclosporin A-Induced Nephropathy
Am J Physiol Renal Physiol. 2022 Jan 24. doi: 10.1152/ajprenal.00332.2021. Online ahead of print.ABSTRACTCalcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity. The present study tested the hypothesis that activation of (pro)renin receptor (PRR) contributes to CsA-induced nephropathy by activating the renin-angiotensin system (RAS). Renal injury in male Sprague-Dawley rats was induced by a low-salt diet combined with CsA as evidenced by elevated plasma creatinine ...
Source: American Journal of Physiology. Renal Physiology - January 24, 2022 Category: Physiology Authors: Jiajia Hu Yandan Tan Yanting Chen Shiqi Mo Brittin Hekking Jiahui Su Min Pu Aihua Lu J David Symons Tianxin Yang Source Type: research
HYPK coordinates degradation of polyneddylated proteins by autophagy
Autophagy. 2021 Nov 26:1-22. doi: 10.1080/15548627.2021.1997053. Online ahead of print.ABSTRACTSelective degradation of protein aggregates by macroautophagy/autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like proteins, NEDD8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show that HYPK...
Source: Autophagy - November 27, 2021 Category: Cytology Authors: Debasish Kumar Ghosh Akash Ranjan Source Type: research
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis
In conclusion, this study indicated that suppression of OATP1A2 would inhibit the progression and prognosis in ESCC.PMID:34823432 | DOI:10.1080/00498254.2021.2001076
Source: Xenobiotica - November 26, 2021 Category: Research Authors: Xiaoli Zheng Jian V Zhang Yanfeng Bai Jiaqi Wang Mingfeng Jiang Su Zeng Lvhua Wang Source Type: research
Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNA
J Inorg Biochem. 2021 Jul 9;223:111540. doi: 10.1016/j.jinorgbio.2021.111540. Online ahead of print.ABSTRACTWith the purpose of obtaining a new dendritic system against cancer, this paper is focused on the synthesis of spherical carbosilane metallodendrimers of different generations holding Ru(II) N-heterocyclic carbene (NHC) on the periphery from the imidazolium precursors. Both imidazolium salt dendrimers and their metallodendrimers counterparts showed promising anticancer activity, similar to cisplatin, mainly at high generations. In addition, both families of second and third generations were able to form dendriplexes ...
Source: Journal of Inorganic Biochemistry - July 17, 2021 Category: Biochemistry Authors: Tamara Rodr íguez-Prieto Sylwia Michlewska Marcin Ho łota Maksim Ionov F Javier de la Mata Jes ús Cano Maria Bryszewska Rafael G ómez Source Type: research
JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes.
CONCLUSIONS: These findings identify JUP as a novel player in the regulation of insulin sensitivity in adipocytes, and suggest that changes in JUP expression could contribute to the effect of SIK2 on insulin signalling in these cells.
PMID: 32966883 [PubMed - as supplied by publisher]
Source: Cellular Signalling - September 19, 2020 Category: Cytology Authors: Negoita F, Vavakova M, Säll J, Laurencikiene J, Göransson O Tags: Cell Signal Source Type: research
Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells.
CONCLUSIONS: GO and MGO induced pro-inflammatory cytokines and MUC5AC/5B expression via ERK1/2, p38 MAPK, and NF-κB in human nasal epithelial cells. These results suggested that GO and MGO may be involved in mucus hypersecretion-related airway diseases.
PMID: 32746708 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - August 2, 2020 Category: ENT & OMF Authors: Kwak S, Choi YS, Na HG, Bae CH, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research
Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.
CONCLUSIONS: CD146 is a potential therapeutic target, and folic acid-conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas.
PMID: 32707539 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 23, 2020 Category: Neurosurgery Authors: Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, Yamashita T, Aratake T, Honke K, Ueba T Tags: J Neurosurg Source Type: research
