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Total 107 results found since Jan 2013.

Identification and function of circular RNA hsa_circ_0071106: A novel biomarker for differentiation degree of esophageal squamous cell carcinoma
CONCLUSION: Hsa_circ_0071106 was a downregulated circRNA related to ESCC and promoted ESCC progression by regulating cell migration and invasion. These findings suggest that hsa_circ_0071106 could be a promising diagnostic biomarker and potential therapeutic target and might predict ESCC's histological differentiation degree.PMID:35390631 | DOI:10.1016/j.prp.2022.153875
Source: Pathology, Research and Practice - April 7, 2022 Category: Pathology Authors: Ying Tang Zhikui Gao Ran Liu Source Type: research

Effects and regulatory pathway of proopinmelanocortin on feeding habit domestication in mandarin fish
Gene. 2023 Jun 17:147581. doi: 10.1016/j.gene.2023.147581. Online ahead of print.ABSTRACTProopiomelanocortin (POMC) is a hormone precursor, and has been reported to participate in domestication. However, its effects on feeding habit domestication in fish are poorly understood. Mandarin fish (Siniperca chuatsi) feeds solely on live prey fish since first-feeding. In the present study, the high expression of pomc in mandarin fish, both the pomc siRNA and MC4R inhibitor treatments increased the success rate of domestication from live prey fish to dead prey fish and food intake of dead prey fish, suggesting the role of pomc on ...
Source: Gene - June 19, 2023 Category: Genetics & Stem Cells Authors: Hai-Lin Lu Ling Li Yun-Liang Miao Hui Liang Jia-Ming Zou Jun-Jie You Xu-Fang Liang Shan He Source Type: research

Function analysis of fish Tollip gene in response to virus infection
Publication date: December 2015 Source:Fish & Shellfish Immunology, Volume 47, Issue 2 Author(s): Jingguang Wei, Meng Xu, Xiuli Chen, Ping Zhang, Pingfei Li, Shina Wei, Yang Yan, Qiwei Qin Toll-interacting protein (Tollip) is one of the important regulatory proteins of Toll-like receptor (TLR) signaling pathways. In previous studies, a Tollip sequence of grouper (Epinephelus coioides) was identified and the signal transduction functions of Tollip were studied. However, the response of Tollip to virus infection has not been characterized from grouper. In the present paper, the Tollip homolog (EtTollip) fro...
Source: Fish and Shellfish Immunology - October 31, 2015 Category: Biology Source Type: research

Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner.
Abstract To investigate potential mechanisms underlying the bioactivity of hydrolyzed fish collagen, we examined the anti-inflammatory actions of subcritical water-hydrolyzed fish collagen (SWFC) in lipopolysaccharide (LPS)-triggered inflammation and endotoxemia. SWFC markedly inhibited LPS-stimulated release of high mobility group box 1 (HMGB1) in murine RAW264.7 macrophages, along with decreased cytosolic translocation of HMGB1. Both the protein and mRNA levels of heme oxygenase-1 (HO-1) were significantly upregulated in SWFC-treated RAW 264.7 cells in an Nrf2-dependent manner. In line with these effects of SWFC...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 13, 2017 Category: Drugs & Pharmacology Authors: Ahn MY, Hwang JS, Ham SA, Hur J, Jo Y, Lee S, Choi MJ, Han SG, Seo HG Tags: Biomed Pharmacother Source Type: research

Association of FGFR1 with ER αmaintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer.
Conclusions: These data suggest the ERα pathway remains active in estrogen-deprived ER+/FGFR1-amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR antagonists. PMID: 28751448 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - July 27, 2017 Category: Cancer & Oncology Authors: Formisano L, Stauffer KM, Young CD, Bhola NE, Guerrero-Zotano AL, Jansen VM, Estrada MM, Hutchinson KE, Giltnane JM, Schwarz LJ, Lu Y, Balko JM, Deas O, Cairo S, Judde JG, Mayer IA, Sanders M, Dugger TC, Bianco R, Stricker T, Arteaga CL Tags: Clin Cancer Res Source Type: research

MicroRNA ‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy
In conclusion, miR‐30a is down‐regulated in hepatic fibrosis models and its overexpression prevents liver fibrogenesis by directly suppressing Beclin1‐mediated autophagy; therefore, miR‐30a may be a new potential therapeutic target for controlling hepatic fibrosis.
Source: Journal of Cellular and Molecular Medicine - July 1, 2017 Category: Molecular Biology Authors: Jianliang Chen, Yue Yu, Shu Li, Yuting Liu, Shu Zhou, Shouji Cao, Jie Yin, Guoqiang Li Tags: Original Article Source Type: research

MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.
In conclusion, miR-30a is down-regulated in hepatic fibrosis models and its overexpression prevents liver fibrogenesis by directly suppressing Beclin1-mediated autophagy; therefore, miR-30a may be a new potential therapeutic target for controlling hepatic fibrosis. PMID: 28766848 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - August 1, 2017 Category: Molecular Biology Authors: Chen J, Yu Y, Li S, Liu Y, Zhou S, Cao S, Yin J, Li G Tags: J Cell Mol Med Source Type: research

Thymosin β4 is involved in the antimicrobial immune response of Golden pompano, Trachinotus ovatus
Publication date: October 2017 Source:Fish & Shellfish Immunology, Volume 69 Author(s): Yun Sun, Xiaojuan Chen, Yue Xu, Qiaohong Liu, Xue Jiang, Shifeng Wang, Weiliang Guo, Yongcan Zhou Thymosin beta belongs to the thymosin family, which consists of a series of highly conserved peptides involved in various biological processes. In teleosts, understanding of the immunological functions of thymosin beta is limited, particularly in vivo, which is essentially unknown. In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4. ...
Source: Fish and Shellfish Immunology - August 30, 2017 Category: Biology Source Type: research

Grass carp (Ctenopharyngodon idella) STAT3 regulates the eIF2 α phosphorylation through interaction with PKR.
Grass carp (Ctenopharyngodon idella) STAT3 regulates the eIF2α phosphorylation through interaction with PKR. Dev Comp Immunol. 2017 Sep 12;: Authors: Wang L, Wu Z, Huang Q, Huang K, Qi G, Wu C, Mao H, Xu X, Wang H, Hu C Abstract In mammals, STAT3 (Signal transducer and activator of transcription 3) plays an important role in growth, multiplication, differentiation and participates in inflammation, tumorigenesis, metabolic disorders and immune response. STAT3 is a protein that shuttles between the nucleus and cytoplasm. Compared to the STAT3 in cell nucleus, we did not know the function of STAT3 in cy...
Source: Developmental and Comparative Immunology - September 12, 2017 Category: Allergy & Immunology Authors: Wang L, Wu Z, Huang Q, Huang K, Qi G, Wu C, Mao H, Xu X, Wang H, Hu C Tags: Dev Comp Immunol Source Type: research

Long non ‐coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR‐31 expression
ConclusionOur results suggest that LOC554202 may play an important role in the progression of chordoma by the direct upregulation of EZH2 and indirect promotion of RNF144B via miR‐31.
Source: Cell Proliferation - September 30, 2017 Category: Cytology Authors: Xianli Ma, Shengjin Qi, Zhenying Duan, Hongzhan Liao, Baohua Yang, Wenbo Wang, Jie Tan, Qinghua Li, Xuewei Xia Tags: ORIGINAL ARTICLE Source Type: research

LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating β-catenin.
In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits β-catenin to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages. PMID: 29258822 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - December 16, 2017 Category: Biochemistry Authors: Huangfu N, Xu Z, Zheng W, Wang Y, Cheng J, Chen X Tags: Biochem Biophys Res Commun Source Type: research

Eriocheir sinensis microRNA-7 targets crab Myd88 to enhance white spot syndrome virus replication
In this study, the function of microRNA-7 (miR-7) in host-virus interaction was investigated. Replication of White spot syndrome virus (WSSV) was enhanced with the overexpression of miR-7 and inhibited with the downregulation of miR-7 by using anti-miRNA oligonucleotide AMO-miR-7. The target gene of miR-7 was predicted using bioinformatics methods. Results showed that crab myeloid differentiation factor 88 (Myd88) could be targeted by miR-7. When the expression of Myd88 was knocked down by sequence-specific siRNA, WSSV copies in crabs were significantly increased. Further findings revealed that knockdown of Myd88, Tube, or...
Source: Fish and Shellfish Immunology - May 27, 2018 Category: Biology Source Type: research

Functional domains of Litopenaeus vannamei transglutaminase and their involvement in immunoregulation in shrimp
Publication date: October 2018Source: Fish & Shellfish Immunology, Volume 81Author(s): Zhou Zheng, Wenning Xu, Jude Juventus Aweya, Mingqi Zhong, Shangjie Liu, Jingsheng Lun, Jiehui Chen, Yueling ZhangAbstractShrimps, which mainly rely on their innate immune system to response to infectious pathogens, have clottable proteins as an important component of this system. While transglutaminases (TGase) are found in Litopenaeus vannamei and constitute part of the coagulation system, the specific immune-related roles played by its functional domains in the immunoregulation of shrimp has not been well understood. In the present st...
Source: Fish and Shellfish Immunology - July 18, 2018 Category: Biology Source Type: research