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Total 445 results found since Jan 2013.
Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKC βII inhibitory molecules
J Cell Mol Med. 2022 Jul 8. doi: 10.1111/jcmm.17345. Online ahead of print.ABSTRACTExcessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where markers that BAT express are induced. Little is known about signalling pathways inducing beiging. Here, inhibition of a signalling pathway regulating alternative pre-mRNA splicing is involved in adipocyte beiging. Clk1/2/4 kinases regulate splicing by phosphorylating factors that process pre-mRNA. Clk1 inhibition by T...
Source: Molecular Medicine - July 8, 2022 Category: Molecular Biology Authors: Achintya Patel Tradd Dobbins Xiaoyuan Kong Rehka Patel Gay Carter Linette Harding Robert P Sparks Niketa A Patel Denise R Cooper Source Type: research
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway
CONCLUSIONS: In conclusion, the results of the present study suggested that oridonin may ameliorate LSS-induced EC dysfunction and oxidative stress by activating NRF2, thereby attenuating AS.PMID:35799227 | DOI:10.1186/s12906-022-03658-2
Source: Atherosclerosis - July 7, 2022 Category: Cardiology Authors: Zhipeng Chen Heqian Liu Xiaoqi Zhao Subinur Mamateli Cheng Liu Lei Wang Jing Yu Yutong Liu Jing Cai Tong Qiao Source Type: research
Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKC βII inhibitory molecules
J Cell Mol Med. 2022 Jul 8. doi: 10.1111/jcmm.17345. Online ahead of print.ABSTRACTExcessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where markers that BAT express are induced. Little is known about signalling pathways inducing beiging. Here, inhibition of a signalling pathway regulating alternative pre-mRNA splicing is involved in adipocyte beiging. Clk1/2/4 kinases regulate splicing by phosphorylating factors that process pre-mRNA. Clk1 inhibition by T...
Source: J Cell Mol Med - July 8, 2022 Category: Molecular Biology Authors: Achintya Patel Tradd Dobbins Xiaoyuan Kong Rehka Patel Gay Carter Linette Harding Robert P Sparks Niketa A Patel Denise R Cooper Source Type: research
Acetate, a gut bacterial product, ameliorates ischemia-reperfusion induced acute lung injury in rats
In this study, we examine whether SCFAs have protective effects against IR-induced ALI and explore possible protective mechanisms. IR-induced ALI was established by 40 min ischemia followed by 60 min reperfusion in isolated perfused rat lungs. Rats were randomly assigned to one of six groups: control, control + acetate (400 mg/kg), IR, and IR + acetate at one of three dosages (100, 200, 400 mg/kg). Bronchoalveolar lavage fluids (BALF) and lung tissues were obtained and analyzed at the end of the experiment. In vitro, mouse lung epithelial cells (MLE-12) subjected to hypoxia-reoxygenation (HR) were pretreated with acetate (...
Source: International Immunopharmacology - August 14, 2022 Category: Allergy & Immunology Authors: Kuei-Yi Hung Shu-Yu Wu Hsin-Ping Pao Wen-I Liao Shi-Jye Chu Source Type: research
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
CONCLUSIONS: PACS-2 has a protective role against lipid-related kidney injury in DKD through SOAT1/SREBPs signaling.PMID:36138342 | DOI:10.1186/s10020-022-00545-x
Source: Molecular Medicine - September 22, 2022 Category: Molecular Biology Authors: Chanyue Zhao Li Li Chenrui Li Chengyuan Tang Juan Cai Yu Liu Jinfei Yang Yiyun Xi Ming Yang Na Jiang Yachun Han Yan Liu Shilu Luo Li Xiao Lin Sun Source Type: research
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation
CONCLUSION: Silencing miR-351 upregulates ITGB3 and activates the PIK3R1/Akt pathway, thereby exerting anti-apoptosis and protective effects on endothelial cells.PMID:36180828 | DOI:10.1186/s10020-022-00547-9
Source: Atherosclerosis - September 30, 2022 Category: Cardiology Authors: Hong Li Dan Song Qihui Liu Linlin Li Xiaoshi Sun Jiamei Guo Dianlian Li Ping Li Source Type: research
Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
CONCLUSION: CAT-1 is upregulated and promotes FLS proliferation by taking up L-arginine, thereby promoting RA progression.PMID:36253807 | DOI:10.1186/s13075-022-02921-8
Source: Cell Research - October 17, 2022 Category: Cytology Authors: Ying Lu Chongbo Hao Shanshan Yu Zuan Ma Xuelian Fu Mingqing Qin Menglei Ding Zengguang Xu Lieying Fan Source Type: research
Apigenin directly interacts with and inhibits topoisomerase 1 to upregulate CD26/DPP4 on colorectal carcinoma cells
Discussion: We conclude that apigenin has a unique fit into the Topo1-DNA functional complex that leads to direct inhibition of Topo1 activity, and suggest that this is the basis for the exceptional interaction with the CRC drug irinotecan. A combined action of these two agents may therefore exert a role to limit local signals that facilitate tumour progression.
Source: Frontiers in Pharmacology - December 22, 2022 Category: Drugs & Pharmacology Source Type: research
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research
GSE225616 Hepatocyte mARC1 Promotes Fatty Liver Disease
Conclusions: Collectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - February 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE223652 Hepatocyte mARC1 Promotes Fatty Liver Disease
ConclusionsCollectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - April 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
