Filtered By:
Nutrition: Diets

This page shows you your search results in order of relevance. This is page number 6.

Order by Relevance | Date

Total 445 results found since Jan 2013.

Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research

Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation
AbstractThe vascular endothelium plays a key role in the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell Piezo1 mediates blood vessel formation, angiogenesis and regulation of blood pressure. However, changes of Piezo1 expression in atherosclerosis (AS) and the role of Piezo1 in the progression of atherosclerotic diseases remains obscure. Thus, the current study is to elucidate the role and mechanism of which Piezo1 mediates vascular inflammation in atherosclerotic mice and vascular endothelial inflammation induced by oxidized low density lipoprotein (ox-LDL) in vitro. Here, we have shown that the ...
Source: Human Cell - January 1, 2022 Category: Cytology Source Type: research

Inclisiran (Leqvio) for LDL-Cholesterol Lowering
Date: March 21, 2022 Issue #:  1646Summary:  The FDA has approved inclisiran (Leqvio– Novartis), a small interfering RNA (siRNA) directed to proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA, as an adjunct to diet and maximally tolerated statin therapy for subcutaneous (SC) treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atheroscler otic cardiovascular disease (ASCVD) who require additional lowering of low-density lipoprotein cholesterol (LDL-C). Inclisiran is the first FDA-approved PCSK9-directed siRNA therapeutic agent.
Source: The Medical Letter - February 8, 2022 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab bempedoic acid evolocumab Ezetimibe Ezetrol Hypercholesterolemia inclisiran Leqvio Nexletol Nexlizet Praluent Repatha Statins Zetia Source Type: research

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells
Cell Death Discov. 2022 Mar 12;8(1):112. doi: 10.1038/s41420-022-00906-9.ABSTRACTHistone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis (AS). However, little is known about the effect of HDAC11 on endothelial cell pyroptosis in AS. Thus, this study aims to investigate the role of HDAC11 in vascular endothelial cell pyroptosis and its molecular mechanism. Firstly, we found that HDAC11 expression was up-regulated and pyroptosis occ...
Source: Atherosclerosis - March 13, 2022 Category: Cardiology Authors: Feng Yao Zhen Jin Zihan Zheng Xiaohan Lv Lingxuan Ren Jianjun Yang Danli Chen Bo Wang Wei Yang Lifang Chen Weirong Wang Jianli Gu Rong Lin Source Type: research

Inclisiran: A Novel Small Interfering RNA Drug for LDL Reduction
This article is protected by copyright. All rights reserved.PMID:35279835 | DOI:10.1002/jcph.2045
Source: The Journal of Clinical Pharmacology - March 13, 2022 Category: Drugs & Pharmacology Authors: Kimberly W Smith C Michael White Source Type: research

Safety and efficacy of therapies for chylomicronemia
Expert Rev Clin Pharmacol. 2022 Jun 28. doi: 10.1080/17512433.2022.2094768. Online ahead of print.ABSTRACTINTRODUCTION: Primary chylomicronemia is characterized by pathological accumulation of chylomicrons in plasma causing severe hypertriglyceridemia, typically >10 mmol/L (>875 mg/dL). Patients with the ultra-rare familial chylomicronemia syndrome (FCS) subtype completely lack lipolytic capacity and respond minimally to traditional triglyceride-lowering therapies. The mainstay of treatment is a low-fat diet, which is difficult to follow and compromises quality of life. New therapies are being developed primarily to ...
Source: Pharmacological Reviews - June 28, 2022 Category: Drugs & Pharmacology Authors: Isabel Shamsudeen Robert A Hegele Source Type: research

Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway
CONCLUSIONS: In conclusion, the results of the present study suggested that oridonin may ameliorate LSS-induced EC dysfunction and oxidative stress by activating NRF2, thereby attenuating AS.PMID:35799227 | DOI:10.1186/s12906-022-03658-2
Source: Atherosclerosis - July 7, 2022 Category: Cardiology Authors: Zhipeng Chen Heqian Liu Xiaoqi Zhao Subinur Mamateli Cheng Liu Lei Wang Jing Yu Yutong Liu Jing Cai Tong Qiao Source Type: research

Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKC βII inhibitory molecules
J Cell Mol Med. 2022 Jul 8. doi: 10.1111/jcmm.17345. Online ahead of print.ABSTRACTExcessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where markers that BAT express are induced. Little is known about signalling pathways inducing beiging. Here, inhibition of a signalling pathway regulating alternative pre-mRNA splicing is involved in adipocyte beiging. Clk1/2/4 kinases regulate splicing by phosphorylating factors that process pre-mRNA. Clk1 inhibition by T...
Source: J Cell Mol Med - July 8, 2022 Category: Molecular Biology Authors: Achintya Patel Tradd Dobbins Xiaoyuan Kong Rehka Patel Gay Carter Linette Harding Robert P Sparks Niketa A Patel Denise R Cooper Source Type: research