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Total 46 results found since Jan 2013.

Targeted Delivery Methods for RNA Interference Are Necessary to Obtain a Potential Functional Cure for HIV/AIDS
Adv Drug Deliv Rev. 2023 Jun 27:114970. doi: 10.1016/j.addr.2023.114970. Online ahead of print.ABSTRACTRibonucleic acid (RNA) is of great interest in many different therapeutic areas including infectious diseases such as immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Thanks to current, advanced treatments for HIV, the diagnosis is no longer a death sentence. However, even with these treatments, latency is suggested to persist in T-lymphocyte-rich tissues including gut-associated lymphatic tissue (GALT), spleen, and bone marrow making HIV an incurable disease. Therefore, it is important to design syst...
Source: Advanced Drug Delivery Reviews - June 29, 2023 Category: Drugs & Pharmacology Authors: Ethan Cisneros Najia Sherwani Olivia L Lanier Nicholas A Peppas Source Type: research

Highlights on Cell-Penetrating Peptides and Polymer-Lipid Hybrid Nanoparticle: Overview and Therapeutic Applications for Targeted Anticancer Therapy
AAPS PharmSciTech. 2023 May 24;24(5):124. doi: 10.1208/s12249-023-02576-x.ABSTRACTPolymer-lipid hybrid nanoparticles (PLHNs) have been widely used as a vehicle for carrying anticancer owing to its unique framework of polymer and lipid combining and giving the maximum advantages over the lipid and polymer nanoparticle drug delivery system. Surface modification of PLHNs aids in improved targeting and active delivery of the encapsulated drug. Therefore, surface modification of the PLHNs with the cell-penetrating peptide is explored by many researchers and is explained in this review. Cell-penetrating peptides (CPPs) are made ...
Source: AAPS PharmSciTech - May 24, 2023 Category: Drugs & Pharmacology Authors: Pragathi Devanand Bangera Divya Dhatri Kara Katikala Tanvi Vamshi Krishna Tippavajhala Mahalaxmi Rathnanand Source Type: research

Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Eur J Pharmacol. 2023 Mar 13:175649. doi: 10.1016/j.ejphar.2023.175649. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is the most prevalent chronic inflammatory skin condition and significantly reduces quality of life. Tight junction (TJ), which is located directly beneath the stratum corneum, maintains skin barrier function and aids in the identification of the cell's "territory". We evaluated seventeen TJ related genes to explore AD related alterations of TJ. Remarkably, we found that the expression of ZO-3, a gene that had not been linked to the development of TJ in AD, was significantly down-regulated in the ski...
Source: European Journal of Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Xueqin Hu Yuan Zhou Jianxin Shi Mingxin Qi Xue Li Yan Yang Chan Zhu Changming Wang Zongxiang Tang Yuxiang Ma Guang Yu Source Type: research

Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways
Mol Cell Biochem. 2023 Feb 1. doi: 10.1007/s11010-023-04668-5. Online ahead of print.ABSTRACTOvarian cancer is one of the leading causes of deaths among women. Despite advances in the treatment regimes, a high rate of diagnosis in the advanced stage makes it almost an incurable malignancy. Thus, more research efforts are required to identify potential molecular markers for early detection of the disease and therapeutic targets to augment the survival rate of ovarian cancer patients. Previously, in this context, we identified dysregulated expression of multimerin 1 (MMRN1) in ovarian cancer. To elucidate the relationship be...
Source: Molecular and Cellular Biochemistry - February 1, 2023 Category: Biochemistry Authors: Abhinav Saini Vikrant Kumar Anil Kumar Tomar Alpana Sharma Savita Yadav Source Type: research

Cancers, Vol. 14, Pages 4123: Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors
lin Cancer is the leading cause of economic and health burden worldwide. The commonly used approaches for the treatment of cancer are chemotherapy, radiotherapy, and surgery. Chemotherapy frequently results in undesirable side effects, and cancer cells may develop resistance. Combating drug resistance is a challenging task in cancer treatment. Drug resistance may be intrinsic or acquired and can be due to genetic factors, growth factors, the increased efflux of drugs, DNA repair, and the metabolism of xenobiotics. The strategies used to combat drug resistance include the nanomedicine-based targeted delivery of drugs an...
Source: Cancers - August 26, 2022 Category: Cancer & Oncology Authors: Muhammad Muzamil Khan Vladimir P. Torchilin Tags: Review Source Type: research

Streptococcus pneumoniae exerts oxidative stress, subverts antioxidant signaling and autophagy in human corneal epithelial cells that is alleviated by tert-Butylhydroquinone
AbstractStreptococcus pneumoniae is one of the leading causes of bacterial keratitis in the developing world and globally. In the current study, we have determined oxidative stress as pathogenesis ofS. pneumoniae infection in corneal tissues and human corneal epithelial cells (HCEC) and explored host immune response of HCEC towardsS. pneumoniae. We also determined whether treatment with tert-Butylhydroquinone (tBHQ), a Nrf2 inducer, could alleviate oxidative stress and reduce bacterial cytotoxicity in these cells. Oxidative stress was determined in corneal tissues of patients and HCEC by immunohistochemistry and immunofluo...
Source: Medical Microbiology and Immunology - March 24, 2022 Category: Microbiology Source Type: research

Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death
This study uncovers the unexpected role of immune surveillance protein DDX58/Rig-1 (DExD/H box helicase 58) in activating macroautophagy/autophagy and protecting from lipotoxicity associated with NAFLD. Here we show for the first time that DDX58 protein is significantly reduced in nonalcoholic steatohepatitis (NASH) mouse model, an aggressive form of NAFLD characterized by inflammation and fibrosis of the liver. In addition to decreased expression of DDX58, we found that DDX58 activity can be attenuated by treatments with palmitic acid (PA), a saturated fatty acid. To investigate whether PA inhibition of DDX58 is harmful t...
Source: Autophagy - May 10, 2021 Category: Cytology Authors: Karla K Frietze Alyssa M Brown Dividutta Das Raymond G Franks Jessie Lee Cunningham Michael Hayward Joseph T Nickels Source Type: research