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HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction
Conclusion: HIV-1 Tat suppressed the induction of autophagy-associated genes and inhibited the formation of autophagosomes. Perturbation of such cellular processes by HIV-1 would impair the effective containment of invading pathogens, thereby providing a favorable environment for opportunistic microbes in HIV-infected individuals.
Source: AIDS - January 2, 2011 Category: Infectious Diseases Tags: Basic Science Source Type: research
