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Total 21 results found since Jan 2013.

Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma
J Immunol Res. 2022 Aug 9;2022:9544827. doi: 10.1155/2022/9544827. eCollection 2022.ABSTRACTDiffuse large B cell lymphoma (DLBCL) is one of the most usual types of adult lymphoma with heterogeneousness in histological morphology, prognosis, and clinical indications. Prior to this, several studies were carried out to determine the DLBCL subtype based on the analysis of the genome profile. However, classification based on assessment of genes related to the immune system has limited clinical significance for DLBCL. We systematically explored the DLBCL gene expression dataset and provided publicly available clinical informatio...
Source: Journal of Immunology Research - August 19, 2022 Category: Allergy & Immunology Authors: Longhao Wang Wei Yuan Lifeng Li Zhibo Shen Qishun Geng Yuanyuan Zheng Jie Zhao Source Type: research

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

SOCS3 ablation enhances DC-derived Th17 immune response against Candida albicans by activating IL-6/STAT3 in vitro
In this study, a si-RNA method is used to repress expression of the cytokine signaling-3 suppressor (SOCS3) in murine bone marrow-DCs, and then the maturation of DCs and the subsequent T-cell response after exposure to C. albicans are monitored in vitro.Key findingsAlong with a higher expression of the DC maturation markers CD40, CD86 and MHC-II, IL-6/STAT3 is markedly upregulated in the SOCS3 siRNA-treated DCs after exposure to C. albicans as compared with control DCs. In response to DCs maturation, CD4+ T cells have an increased expression of Th17 cell markers –– including the retinoic acid-related orphan nuclear hor...
Source: Life Sciences - March 6, 2019 Category: Biology Source Type: research

JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia.
Abstract Mutations in the gene JAGN1 were recently discovered in patients with severe congenital neutropenia (SCN). Neutrophils release neutrophil extracellular traps (NETs) consisting of decondensed chromatin decorated with various granular proteins such as neutrophil elastase and myeloperoxidase (MPO) to combat microbial infections. However, whether JAGN1 is required for the formation or function of NETs is not known. Here, we analyzed primary neutrophils from a patient with homozygous JAGN1 mutations with respect to phorbol myristate acetate (PMA)-induced NET formation. NET release was observed, but there appea...
Source: Journal of Leukocyte Biology - August 14, 2018 Category: Hematology Authors: Khandagale A, Lazzaretto B, Carlsson G, Sundin M, Shafeeq S, Römling U, Fadeel B Tags: J Leukoc Biol Source Type: research

TLR-2, IL-10 and IL-17-mediated immunity in experimental chemotherapy murine model of systemic candidiasis; cyclophosphamides' impact and roles
In this study, following the establishment of infection and immunosuppression in Balb/c mice model, the mRNA/protein levels of TLR-2, IL-10, IL-17, and Myeloperoxidase (MPO) in serum/kidney were measured using Real-time PCR and ELISA respectively. The survival of mice was checked daily and organ fungal burden was calculated and the histology samples were prepared. Results indicated that the mRNA and protein levels of IL-10, IL-17 and MPO were significantly elevated in immunosuppressed-infected mice (P < 0.05). Conversely, the mRNA level of TLR-2 in this mice were significantly decreased (P < 0.05). We...
Source: Microbial Pathogenesis - May 5, 2018 Category: Infectious Diseases Source Type: research

Silencing SOCS1 in dendritic cells promote survival of mice with systemic Candida albicans infection via inducing Th1-cell differentiation.
Abstract Enhancing the immunity conferred by dendritic cells (DCs) to fungal infection represents a promising strategy in the number of immunocompromised individuals. In a previous study, we demonstrated that suppressor of cytokine signaling 1 (SOCS1) silencing can promote the maturation of DCs and induce an immune response against Candida albicans (C. albicans) in vitro. Herein, the effectiveness of SOCS1 suppression administered by SOCS1-siRNA-treated DCs is further evaluated in systemic candidiasis mouse model. The SOCS1-silenced DCs increase mouse survival and significantly decrease fungal colonization in the ...
Source: Immunology Letters - March 23, 2018 Category: Allergy & Immunology Authors: Shi D, Li D, Wang Q, Kong X, Mei H, Shen Y, Liu W Tags: Immunol Lett Source Type: research

Candida albicans {beta}-Glucan-Containing Particles Increase HO-1 Expression in Oral Keratinocytes via a Reactive Oxygen Species/p38 Mitogen-Activated Protein Kinase/Nrf2 Pathway Host Response and Inflammation
Oral keratinocytes provide the first line of host defense against oral candidiasis. We speculated that interactions of fungal cell wall components with oral keratinocytes regulate the stress response against Candida infection and examined the expression of genes induced by heat-killed Candida albicans in oral immortalized keratinocytes using a cDNA microarray technique. Of 24,000 genes revealed by that analysis, we focused on HO-1, a stress-inducible gene, as its expression was increased by both heat-killed and live C. albicans. In histological findings, HO-1 expression in the superficial layers of the oral epithelium foll...
Source: Infection and Immunity - March 22, 2018 Category: Infectious Diseases Authors: Ishida, Y., Ohta, K., Naruse, T., Kato, H., Fukui, A., Shigeishi, H., Nishi, H., Tobiume, K., Takechi, M. Tags: Host Response and Inflammation Source Type: research

Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
Chem. Commun., 2017, Advance Article DOI: 10.1039/C6CC10287E, CommunicationAlbert Gandioso, Anna Massaguer, Nuria Villegas, Candida Salvans, Dani Sanchez, Isabelle Brun-Heath, Vicente Marchan, Modesto Orozco, Montserrat Terrazas Efficient click siRNA-peptide conjugation for targeted delivery into tumor cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 20, 2017 Category: Chemistry Authors: Albert Gandioso Source Type: research

Efficient siRNA-peptide conjugation for specific targeted delivery to tumor cells
Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C6CC10287E, CommunicationAlbert Gandioso, Anna Massaguer, Nuria Villegas, Candida Salvans, Dani Sanchez, Isabelle Brun-Heath, Vicente Marchan, Modesto Orozco, Montserrat Terrazas Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 13, 2017 Category: Chemistry Authors: Albert Gandioso Source Type: research

Candida glabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-κB
Publication date: February 2016 Source:Microbial Pathogenesis, Volume 91 Author(s): Xue Zhang, Jian Bai, Cheng-Lin Wu, Ye Wu, Ying Zhao, Wen-Ming Song, Xue-Ping Luo An increasing number of reports identified Candida glabrata (C. glabrata) as the important causative agent of invasive pulmonary fungal infection. However, little is known about immune responses to C. glabrata in rat tracheal epithelial cell (RTEC). Here, the effect of C. glabrata on RTEC and the role of TLR-2 and NF-κB in the immune response were investigated by treatment with TLR-2 siRNA and NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC), re...
Source: Microbial Pathogenesis - December 25, 2015 Category: Infectious Diseases Source Type: research

C.glabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-κB
Publication date: Available online 23 October 2015 Source:Microbial Pathogenesis Author(s): Xue Zhang, Jian Bai, Cheng-Lin Wu, Ye Wu, Ying Zhao, Wen-Ming Song, Xue-Ping Luo An increasing number of reports identified Candida glabrata (C.glabrata) as the important causative agent of invasive pulmonary fungal infection. However, little is known about immune responses to C.glabrata in rat tracheal epithelial cell (RTEC). Here, the effect of C.glabrata on RTEC and the role of TLR-2 and NF-κB in the immune response were investigated by treatment withTLR-2 siRNA and NF-κB inhibitor pyrrolidinedithiocarbamate (PDTC), re...
Source: Microbial Pathogenesis - October 24, 2015 Category: Infectious Diseases Source Type: research

Chitinase 3-Like 1 Promotes Candida albicans Killing and Preserves Corneal Structure and Function by Controlling Host Antifungal Responses Fungal and Parasitic Infections
This study sought to elucidate the role of CHI3L1 in augmenting the corneal innate immune response to Candida albicans infection in an animal model of fungal keratitis. Flagellin applied topically 24 h prior to C. albicans inoculation significantly protected the corneal from C. albicans and induced CHI3L1 expression in C57BL/6 mouse corneas. CHI3L1, however, played a detectable but minor role in flagellin-induced protection. While C. albicans keratitis was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly amelior...
Source: Infection and Immunity - September 10, 2015 Category: Infectious Diseases Authors: Gao, N., Yu, F.-S. X. Tags: Fungal and Parasitic Infections Source Type: research