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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
CUL4A promotes the invasion of cervical cancer cells by regulating NF- κB signaling pathway.
CONCLUSIONS: CUL4A promotes the invasion of CC cells through the NF-κB signaling pathway.
PMID: 33155196 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Menaquinone-7 protects astrocytes by regulating mitochondrial function and inflammatory response under hypoxic conditions.
CONCLUSIONS: Our study is the first to confirm that MK-7 can protect astrocytes from hypoxia-induced cytotoxicity, possibly by inhibiting mitochondrial dysfunction and the expression of proinflammatory cytokines. Gas6 may also participate in these protective effects.
PMID: 33090426 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - October 23, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LncRNA UCA1 regulates cervical cancer survival and EMT occurrence by targeting miR-155.
CONCLUSIONS: UCA1 expression in cervical cancer is increased and related to patient survival and miR-155 expression is reduced. Lnc-RNA UCA1 regulates EMT occurrence in cervical cancer cells by targeting miR-155.
PMID: 33090390 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - October 23, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
CONCLUSIONS: Rap2A acted as a promotor in the development of BC. Our findings suggested that Rap2A might be a new potential therapeutic target marker for BC treatment.
PMID: 33015796 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma.
CONCLUSIONS: Silencing the OTX1 gene suppressed the proliferation, migration and invasion of NCI-H292 and XWLC cells, impeded the cell cycle transition from G2 to M phase, and accelerated apoptosis, revealing OTX1, a regulator of NSCLC, as a potential new therapeutic target.
PMID: 33015792 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effect of lncRNA-BLACAT1 on drug resistance of non-small cell lung cancer cells in DDP chemotherapy by regulating cyclin D1 expression.
CONCLUSIONS: LncRNA-BLACAT1 regulates the expression of Cyclin D1, reduces the malignant phenotype of drug-resistant cells, and increases the sensitivity of lung cancer cells to DDP.
PMID: 33015788 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Significance of TRPS1 in the development and clinicopathologic of hepatocellular carcinoma.
CONCLUSIONS: TRPS1 plays a key role in the development of HCC and is closely associated with the clinicopathological parameters of HCC patients. Hence, it is proposed that TRPS1 may serve as a novel prognostic marker and a potential therapeutic target for HCC treatment.
PMID: 33015773 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Sirt7 protects chondrocytes degeneration in osteoarthritis via autophagy activation.
CONCLUSIONS: Overall, these findings suggested that Sirt7 was suppressed in the degenerated cartilage. Sirt7 deficiency does harm to the autophagy level, affecting CHs metabolism, while the upregulation of Sirt7 activated autophagy and protected CHs degeneration. An appropriate increase in autophagy can protect CHs but has no effect on Sirt7 expression.
PMID: 33015765 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LncRNA FGD5-AS1/miR-5590-3p axis facilitates the proliferation and metastasis of renal cell carcinoma through ERK/AKT signalling.
CONCLUSIONS: Mechanistically, lncRNA FGD5-AS1 can competitively interact with miR-5590-3p and regulate the downstream signalling of ErkAKT to enhance the malignancy of tumours. This lncRNA could become a potential target molecule for treating and diagnosing RCC.
PMID: 32964964 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 24, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
TGF- β1/WISP1/Integrin-α interaction mediates human chondrocytes dedifferentiation.
CONCLUSIONS: TGF-β1 and WISP1 interact to induce CHs dedifferentiation, which was mainly by the mediation of the Integrin-αV subunit. On the contrary, Integrin-α5 shows a protective effect during the WISP1 caused CHs dedifferentiation.
PMID: 32964955 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 24, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-145 targeting BNIP3 reduces apoptosis of chondrocytes in osteoarthritis through Notch signaling pathway.
CONCLUSIONS: MiR-145 can reduce OA-induced chondrocyte apoptosis through targeted inhibition on BNIP3 and regulation on Notch signaling pathway.
PMID: 32894532 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 8, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Astaxanthin protecting myocardial cells from hypoxia/reoxygenation injury by regulating miR-138/HIF-1 α axis.
CONCLUSIONS: AST can exert a protective function in myocardial cells via regulating the expression of miR-138/HIF-1α axis.
PMID: 32744699 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
KLF7 promotes macrophage activation by activating the NF- κB signaling pathway in epicardial adipose tissue in patients with coronary artery disease.
CONCLUSIONS: Taken together, these results indicate that KLF7 enhances macrophage activation, mediated by JNK-NF-κB signaling pathways in EAT. This suggests that KLF7 may be a potential therapeutic target for cardiovascular diseases such as CAD.
PMID: 32633394 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Knockdown of p66ShcA activates Nrf2 pathway to protect cardiomyocytes from oxidative stress and inflammation induced by H2O2.
CONCLUSIONS: Knockdown of p66ShcA can activate Keap1/Nrf2 pathway, which inhibits H2O2-induced oxidative stress and inflammation in H9c2 cells.
PMID: 32633393 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis.
CONCLUSIONS: These data suggest that circ-ABCB10 affects glioma progression by regulating the miR-620/FABP5 axis, and circ-ABCB10 might be used as a potential target for the treatment of glioma.
PMID: 32633377 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
