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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
HIFs-MiR-33a-Twsit1 axis can regulate invasiveness of hepatocellular cancer cells.
CONCLUSIONS: MiR-33a downregulation in HCC cells is hypoxia-induced and is a result of HIFs upregulation. MiR-33a can modulate EMT and invasion of hepatocellular cancer cells at least partly via downregulating Twist1.
PMID: 27460728 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 29, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effects of silencing PTTG expression by small interference RNA.
CONCLUSIONS: Recombinant small interference RNA (siRNA) expression vector targeting PTTG successfully inhibited the cell proliferation and induced apoptosis in endometrial carcinoma cells and increased the cancer cells vulnerability to the effects of radiation.
PMID: 27424983 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 21, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Metastasis associated in colon cancer 1 (MACC1) promotes growth and metastasis processes of colon cancer cells.
CONCLUSIONS: MACC1 promotes the growth and metastasis processes of CC cells.
PMID: 27424982 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 21, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Phosphocreatine attenuates angiotensin II-induced cardiac fibrosis in rat cardiomyocytes through modulation of MAPK and NF-κB pathway.
CONCLUSIONS: Our study determined that PCr protected cardiomyocytes from Ang II-induced CF through inhibition of MAPK and NF-κB pathway.
PMID: 27383329 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression.
CONCLUSIONS: Vitamin E accelerated breast cancer growth by reducing ROS production and p53 expression.
PMID: 27383327 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ERK1/2/p53 and NF-κB dependent-PUMA activation involves in doxorubicin-induced cardiomyocyte apoptosis.
CONCLUSIONS: DOX induced apoptosis and inhibited growth of H9c2 cells by activation of ERK1/2/p53 and NF-κB dependent-PUMA signaling pathway.
PMID: 27338072 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Evidence for a role of GPRC6A in prostate cancer metastasis based on case-control and in vitro analyses.
CONCLUSIONS: These findings suggest that GPRC6A is associated with aggressive PCa. GPRC6A knockdown inhibits the PCa cells migration and invasion, and GPRC6A overexpression promotes the EMT. It is suggested that GPRC6A may serve as a potential therapeutic target for metastatic PCa.
PMID: 27338047 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro.
CONCLUSIONS: These results demonstrate that CI-1040 induce apoptosis of U-937 cells and might be a new therapeutic option for the treatment of AML.
PMID: 27249593 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 3, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-99a suppress proliferation, migration and invasion through regulating insulin-like growth factor 1 receptor in breast cancer.
CONCLUSIONS: Our findings demonstrated that miR-99a could inhibit the malignancy of breast cancer cell by directly down-regulation of IGF-1R. These results indicated that miR-99a may be an important biomarker for prognosis and anticancer therapy in breast cancer in the future.
PMID: 27212167 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.
CONCLUSIONS: These findings demonstrate that combined treatment with GC7 could enhance cetuximab sensitivity by inhibiting EIF5A2 in NSCLC cells, implying the potential clinical application of GC7 in cetuximab-based chemotherapy for NSCLC patients.
PMID: 27097942 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 23, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
USP4 promotes invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal.
CONCLUSIONS: Therapies targeting the USP4 inhibits invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal. These results indicate that USP4 is an attractive target for breast cancer therapy.
PMID: 27049265 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
PRAME promotes in vitro leukemia cells death by regulating S100A4/p53 signaling.
CONCLUSIONS: Our results suggest that the leukemias expressing high levels of PRAME has a favorable prognosis. PRAME promotes in vitro leukemia cells death by regulating S100A4/p53 signaling.
PMID: 27049257 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Laryngeal squamous cell carcinoma progression is associated with the NFκB signaling pathway regulated by IκB kinase β.
CONCLUSIONS: The NFκB signaling pathway involved TNFR1, IKK-β, and FADD is significantly associated with the development of LSCC. Over-expressed IKK-β efficiently inhibits cell apoptosis and has positive effects on cell proliferation and migration.
PMID: 26914121 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 27, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Clinical significance of sCIP2A levels in breast cancer.
CONCLUSIONS: Our results suggest that serum CIP2A is significantly higher in patients with breast cancer, which is a potential biomarker to make a distinction between breast cancer patients and healthy controls. Higher serum CIP2A levels positively associated with the aggressive phenotype of breast cancer, and forecasts poor prognosis for patients with breast cancer. Knockdown of CIP2A may be a novel target for prevention and treatment of breast cancer.
PMID: 26813457 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 29, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Knockdown of PRAME enhances adriamycin-induced apoptosis in chronic myeloid leukemia cells.
CONCLUSIONS: PRAME is responsible for the inherent low levels of spontaneous apoptosis in K562 cells. The combination of PRAME siRNA with ADR induced more intense apoptosis compared with each single treatment. PRAME siRNA in combination with ADR is well tolerated and shows greater efficacy than either agent alone in mouse xenograft models.
PMID: 26744874 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 15, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
