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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.
CONCLUSIONS: SCCRO is associated with progression and prognosis of PC. After SCCRO gene was transferred, the growth of Lncap cells was inhibited, and ability of invasion and migration decreased by reducing the expression of FAK and MMP-2. SCCRO has potential to become a new target for the treatment of PC.
PMID: 29077169 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 28, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ZEB1 promotes prostate cancer proliferation and invasion through ERK1/2 signaling pathway.
CONCLUSIONS: Inhibition of ZEB1 promoted prostate cancer apoptosis, restrained proliferation, and suppressed invasion through down-regulating ERK1/2 signaling pathway.
PMID: 29028100 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Functional impact of Galectin-3 and TRAIL expression in breast cancer cells.
CONCLUSIONS: The expression level of Galectin-3 in breast cancer tissues was significantly increased compared with that in normal tissues, while the level of TRAIL protein was significantly decreased in cancer tissue. The biological role of these two proteins seems to be synergistic in inhibiting apoptosis of cancer cells. Therefore, the evaluation method that combined both Galectin-3 and TRAIL is of great clinical value in the evaluation of clinical prognosis of patients with breast cancer.
PMID: 28925481 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 21, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Down-regulation of survivin enhances paclitaxel-induced Hela cell apoptosis.
CONCLUSIONS: Down-regulation of survivin promoted paclitaxel-induced apoptosis of cervical cancer Hela cells.
PMID: 28829489 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 23, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Expression of miR-195 in laryngeal squamous cell carcinoma and its effect on proliferation and apoptosis of Hep-2.
CONCLUSIONS: The expression of miR-195 was significantly decreased in laryngeal carcinoma tissues, which was closely related to the clinicopathological characteristics of LSCC. miR-195 may inhibit the proliferation and promote the apoptosis of Hep-2 by regulating Bcl-2 expression, which as an anti-oncogene could have the potential to be a therapeutic strategy in the treatment of LSCC.
PMID: 28770960 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MicroRNA-200c exacerbates the ischemia/reperfusion injury of heart through targeting the glutaminase (GLS)-mediated glutamine metabolism.
CONCLUSIONS: This study reports an important function of miR-200c in the regulation of glutamine metabolism during ischemia/reperfusion injury and will contribute to the development of new diagnostic and therapeutic interventions for the protection of IR.
PMID: 28770953 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The study on expression of CIAPIN1 interfering hepatocellular carcinoma cell proliferation and its mechanisms.
CONCLUSIONS: CIAPIN1 played an important role in the proliferation of liver cancer cells through increasing the expressions of cell cycle related proteins Cyclin D1, CDK2, CDK4, and Cyclin E.
PMID: 28742201 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 27, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Hypoxia promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells via inducing Twist1 expression.
CONCLUSIONS: Hypoxia promotes hepatocellular carcinoma cells SMMC-7721 EMT by upregulating the expression of Twist1.
PMID: 28742200 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 27, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Cyramza induces apoptosis of HCC4006 cell by affecting the level of Bcl-w.
CONCLUSIONS: Cyramza induced the apoptosis of non-small lung cancer cell line HCC4006 via the downregulation of Bcl-w.
PMID: 28742199 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 27, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The role of Notch1 genes in lung cancer A594 cells and the impact on chemosensitivity.
CONCLUSIONS: The Notch1 siRNA can effectively inhibit the expression of Notch1 gene, inhibit the proliferation of lung cancer A549 cells and increase the sensitivity to chemotherapeutic drugs.
PMID: 28678318 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Long non-coding RNA TUG1 can promote proliferation and migration of pancreatic cancer via EMT pathway.
CONCLUSIONS: These data suggest that lncRNA TUG1 may enhance the proliferation and migration of pancreatic cancer cells through EMT pathway.
PMID: 28617552 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Overexpression of β-arrestin2 induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma.
CONCLUSIONS: The overexpression of β-arrestin2 can inhibit the growth of RCC cells in vitro, and β-arrestin2 acts as a tumor suppressor gene in RCC. The main mechanism may directly suppress the phosphorylation of IkBa and indirectly suppress NFkB activation. Thus, β-arrestin2 is expected to be an important marker of RCC prognosis and a new therapeutic target.
PMID: 28485809 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 11, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effect of ZEB2 silencing on cisplatin resistance in gastric cancer.
CONCLUSIONS: ZEB2 silencing can effectively make gastric cells sensitive to cisplatin treatment in vitro.
PMID: 28485807 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 11, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effects of ZEB1 on regulating osteosarcoma cells via NF- κB/iNOS.
CONCLUSIONS: Inhibition of ZEB1 can facilitate osteosarcoma cell apoptosis and inhibit cell proliferation or invasion via down-regulating NF-kB/iNOS signal pathway.
PMID: 28387915 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
CONCLUSIONS: Sirtuin 4 facilitates Adriamycin-induced aging of SMCC7721 liver cancer cells via inhibiting JAK2/STAT3 signal pathway, thus providing one novel anti-cancer strategy.
PMID: 28387906 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
