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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
HCP5 promotes colon cancer development by activating AP1G1 via PI3K/AKT pathway.
CONCLUSIONS: HCP5 was significantly increased in CC and enhanced the proliferation and migration of CC cells by inhibiting the AP1G1 expression. HCP5 promoted CC development by activating the PI3K/AKT pathway.
PMID: 31002129 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MicroRNA-448 inhibits the regeneration of spinal cord injury through PI3K/AKT/Bcl-2 axis.
CONCLUSIONS: MicroRNA-448 is upregulated after SCI, which may be involved in the regenerative process of spinal motor nerves by regulating PI3K/AKT/Bcl-2 axis.
PMID: 31002121 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-335 suppresses cell proliferation and migration by upregulating CRKL in bladder cancer.
CONCLUSIONS: miR-335 could suppress BC cell proliferation and migration by upregulating of CRKL.
PMID: 30964165 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 11, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The JAK2/STAT3 signaling pathway is required for inflammation and cell death induced by cerulein in AR42J cells.
CONCLUSIONS: These findings point to a novel role for the JAK2/STAT3 signaling pathway in the progression of cerulein-induced AP.
PMID: 30840302 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Autophagy in pulmonary macrophages mediates lung inflammatory injury via c-Src tyrosine kinase pathway activation during mechanical ventilation.
CONCLUSIONS: Our results suggested that autophagy caused VILI via regulating c-Src activation, which implies that c-Src may serve as a promising therapeutic target in VILI.
PMID: 30840292 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ZEB1 causes the production of hsa-microRNA-99b/let-7e/microRNA-125a cluster and promotes invasion of liver cancer cells.
CONCLUSIONS: Hsa-microRNA-99b/let-7e/microRNA-125a cluster is highly-expressed in hepatocarcinoma, and its expression can be regulated by ZEB1. In addition, the overexpression of this cluster can promote the invasion of liver cancer cells and advance liver cancer progression.
PMID: 30840268 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MEG3 promotes liver cancer by activating PI3K/AKT pathway through regulating AP1G1.
CONCLUSIONS: Low expression of MEG3 could promote the proliferative and invasive abilities of hepatoma cells and accelerate cell cycle. The mechanism may be related to the inhibition of AP1G1 expression and activation of PI3K/AKT pathway.
PMID: 30840267 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF- κB pathway.
CONCLUSIONS: The knockdown of lncRNA MALAT1 can significantly improve the septic lung injury in mice, whose mechanism may be related to its inhibition on the p38 MAPK/p65 NF-κB signaling pathway.
PMID: 30779099 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Cellular mechanism of T β4 intervention in liver fibrosis by regulating NF-κB signaling pathway.
CONCLUSIONS: Tβ4 significantly inhibited IL-1β-induced HSC-LX2 cell proliferation. The mechanism may involve decreased activation of the NF-κB pathway, decreased expression of p-IKB and nuclear translocation of p65. Therefore, Tβ4 had the effect of reversing liver fibrosis.
PMID: 30779097 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
EGF promotes HIF-1 α expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3.
CONCLUSIONS: In SW480 cells, EGF regulated HIF-1α through the STAT3 phosphorylation pathway, eventually promoting the occurrence and metastasis of colorectal cancer.
PMID: 30779072 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206.
CONCLUSIONS: According to the results, we found that lncRNA RMRP was closely related to the progression of bladder cancer, which could be a potential target for treating BC patients.
PMID: 30779067 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Influences of LncRNA SNHG20 on proliferation and apoptosis of glioma cells through regulating the PTEN/PI3K/AKT signaling pathway.
CONCLUSIONS: Inhibiting the SNHG20 expression in glioma cells can increase the apoptosis of glioma cells, and the mechanism may be related to the SNHG20-mediated PTEN/PI3K/AKT signaling pathway.
PMID: 30657567 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 20, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Significant association of DIRC1 overexpression with tumor progression and poor prognosis in gastric cancer.
CONCLUSIONS: These findings offer clinical associations and an in vitro evidence showing that the knockdown of DIRC1 impeded the GC carcinogenicity possibly via suppression of AKT/mTOR signaling. This work might provide a potential therapeutic target for GC treatment.
PMID: 30575946 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MicroRNA-29a enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis by targeting heme oxygenase-1.
CONCLUSIONS: MiR-29a functionally promoted podocytes autophagy and inhibited apoptosis through the HO-1dependent pathway in the HG condition.
PMID: 30575934 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LncRNA LOC554202 promotes proliferation and migration of gastric cancer cells through regulating p21 and E-cadherin.
CONCLUSIONS: LncRNA LOC554202 is highly expressed in GC cells. It could promote proliferative and migratory abilities by downregulating expression levels of p21 and E-cadherin in GC cells.
PMID: 30575909 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
