Sirt7 protects chondrocytes degeneration in osteoarthritis via autophagy activation.

CONCLUSIONS: Overall, these findings suggested that Sirt7 was suppressed in the degenerated cartilage. Sirt7 deficiency does harm to the autophagy level, affecting CHs metabolism, while the upregulation of Sirt7 activated autophagy and protected CHs degeneration. An appropriate increase in autophagy can protect CHs but has no effect on Sirt7 expression. PMID: 33015765 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/33015765?dopt=Abstract

Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research