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Source: European Respiratory Journal
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Total 164 results found since Jan 2013.
The Hippo pathway effectors TAZ and YAP are sequentially required in lung development
Conclusion: Our results indicate that TAZ and YAP function at different stages of lung development in lung epithelial cells and essential for proper lung development. Our results suggested the existence of a novel pathway between TGF-beta and Shh.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Isago, H., Mitani, A., Kohno, S., Nagoshi, H., Ishimori, T., Saito, M., Tamiya, H., Mikami, Y., Horie, M., Urushiyama, H., Jo, T., Tanaka, G., Hamamoto, R., Terasaki, Y., Nagase, T. Tags: Lung and airway developmental biology Source Type: research
Downregulation of lysosome-associated membrane protein-2A accelerates cigarette smoke extract-induced aging and apoptosis in human bronchial epithelial cells
In this study, we evaluated the expression level of LAMP-2A in lung tissues and primary human bronchial epithelial cells (HBEC) of the normal, smoker, and COPD patients and investigated the role of LAMP-2A in cigarette smoke extract (CSE)-induced aging and death in lung epithelial cells (BEAS-2B). The protein level of LAMP-2A significantly decreased in lung homogenates from smokers and COPD patients compared with never smokers. Immunohistochemical analysis showed a significant decrease of LAMP-2A level in lung epithelial cells. Primary HBEC from smokers and COPD patients expressed a lower level of LAMP-2A than never smoker...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Lee, K.-H., Jeong, Y., Kim, J. Y., Lee, C.-H., Yoo, C.-G. Tags: Mechanisms of lung injury and repair Source Type: research
Hippo Effector YAP regulates Autophagy key effector p62 in Lung Adenocarcinoma
Conclusion: Taken together, our findings uncover a significant regulatory axis for autophagic key factor p62 by Hippo effector YAP in EGFR-TKI resistant lung adenocarcinoma. Targeting the autophagy by YAP could provide an effective therapeutic strategy for intractable lung cancer such as EGFR-TKI-resistant lung adenocarcinoma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chung, C., Kim, J. O., Park, D. I., Lee, D., Lee, J. E., Park, H. S., Kang, D. H., Kim, Y. Tags: Lung cancer Source Type: research
Role of MUC4 in idiopathic pulmonary fibrosis
Conclusions: MUC4 collaborates with pSmad2/3 and pTGFβRI inducing IPF progression. Therefore, pharmacologic targeting of MUC4 may be a potential target to design new therapies for IPF.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Ballester Llobell, B., Milara Paya, J., Montero Magallo, P., Roger Laparra, I., Estornut Navarro, C., Cortijo Gimeno, J. Tags: Idiopathic interstitial pneumonias Source Type: research
LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium
Conclusions: Our data suggest that decreased UPF1 levels in asthma BECs contribute to impaired antiviral immunity and RV-induced exacerbations in asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wong, T., Rynne, J., Howarth, P. H., Edwards, M. R., Martinez-Nunez, R. T. Tags: Respiratory infections Source Type: research
BMI is reduced in COPD
Conclusion: Our results suggest that the absence of BMI1 accelerates senescence in alveolar epithelial cells and promotes COPD formation.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Yao, X., Wu, , Adock, I. Tags: Allergy and immunology Source Type: research
Involvement of Parkin-mediated mitophagy in COPD-related sarcopenia pathogenesis
Conclusion: These results suggest that reduction of Parkin can be involved in sarcopenia formation through impaired myogenic differentiation and reduced mitophagy during COPD pathogenesis.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Ito, A., Hashimoto, M., Tanihata, J., Kawamoto, H., Hosaka, Y., Ichikawa, A., Kadota, T., Fujita, Y., Minagawa, S., Numata, T., Hara, H., Araya, J., Kuwano, K. Tags: Molecular pathology and funct. genomics Source Type: research
DTX3L mediated regulation of TBK1 positively regulates type I IFN signalingpathway and cellular antiviral response
Conclusions: 1)DTX3L had the function of anti-RSV infection.2) DTX3L defect RSV through both promotion of IFN generation or IFN signal transduction components.3) DTX3L may promote IFN pathway by mediating the phosphorylation of TBK1 .
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hao, C., Huang, J., Ma, Y. Tags: Paediatric respiratory infection and immun. Source Type: research
Latent TGF-ss binding protein 4 is an important factor that influences anti-inflammatory and cell-protective responses in the pathogenesis of pulmonary emphysema
Conclusion: Our results suggest a unique function for LTBP-4 that influences anti-inflammatory and cell-protective responses in elastic fiber assembly. These data are potentially useful for the treatment or prevention of pulmonary emphysema.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Ishii, M., Yamaguchi, Y., Hamaya, H., Iwata, Y., Ogawa, S., Akishita, M. Tags: Airway cell biology and immunopathology Source Type: research
6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway
Conclusions: Our findings indicate that inhibition of G6PD may have anti-fibrotic effects on pulmonary fibrosis, suggesting that G6PD is implicated as a potential therapeutic target in IPF.Figure: Comparison of hydroxyproline levels in the bleomycin induced lung fibrosis mouse model according to the treatment
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kim, M., Kim, H.-S., Moon, S.-J., Yoo, H. J., Song, J. W. Tags: Mechanisms of lung injury and repair Source Type: research
GCN2 regulates BMP signaling: consequence for PVOD pathobiology and therapeutic management
Conclusion: GCN2 loss-of-function negatively regulates SMAD1/5/9 phosphorylation. Despite this dampened BMP signaling, exogenous BMP9 was still able to reverse GCN2 inhibition-induced hPMEC proliferation. BMP9 may hence be considered as potential therapeutic options for PVOD
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Manaud, G., Lambert, M., Soilih, B., Girerd, B., Soubrier, F., Bignard, J., Claude, O., Lecerf, F., Florio, M., Sun, B., Nadaud, S., Verleden, S., Remy, S., Anegon, I., Mercier, O., Fadel, E., Simmoneau, G., Humbert, M., Montani, D., Antigny, F., Perros, Tags: Pulmonary hypertension Source Type: research
Regulation of Type I cytokine receptors as a target for pulmonary arterial hypertension treatment?
Conclusions: TypeIR intracellular trafficking regulation is altered in PAH patients compared to controls, due to a shift in USP8/RNF41 ratio. Restoring USP8/RNF41 ratio in PA-SMCs may represent a potential target in PAH.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Jutant, E.-M., Tu, L., Le Vely, B., Thuillet, R., Humbert, M., Guignabert, C., Huertas, A. Tags: Pulmonary hypertension Source Type: research
Role of c-Abelson in the loss of genome integrity in endothelial cells in pulmonary arterial hypertension
Conclusions: Our results demonstrate a central role of c-Abl in the loss of DNA integrity in iPAH P-ECs.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Le Vely, B., Berrebeh, N., Phan, C., Thuillet, R., Humbert, M., Huertas, A., Guignabert, C., Tu, L. Tags: Pulmonary hypertension Source Type: research
LSC - 2020 - Epithelial-mesenchymal transition induced by cigarette smoke in lung epithelial cells is associated with metabolic reprogramming and senescence
A dysregulated epithelial–mesenchymal transition (EMT) contributes to tumor progression, fibrosis and lung tissue remodeling in Chronic Obstructive Pulmonary Disease (COPD). Cigarette smoke, a risk factor for all these processes, induces oxidative stress, mitochondrial damage and drives cell senescence by reducing FoxO3, an anti-aging factor. Mitochondrial dysfunction is involved in aging and increases lactate generation, which is correlated with EMT induction.Here, we investigated the cigarette smoke extract (CSE) effects on mitochondrial status and cell metabolism and on the expression of EMT markers in lung epithe...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Tags: Airway cell biology and immunopathology Source Type: research
Cbx4 Regulates RNA Binding Protein MEX-3B To Thymic stromal lymphopoietin Expression Sumoylation In Epithelium Of HDM-induced Allergic Inflammation
Conclusion: CBX4/MEX-3B/TSLP axis involved in TSLP-mediated airway inflammation,suggesting that targeting SUMO E3 ligase activity of CBX4 would be a novel target for the treatment of asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: shixiu, l., Changhui, Y., Zicong, Z., Zili, Z., Jieyi, L., Shaoxi, C. Tags: Allergy and immunology Source Type: research
