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Source: European Respiratory Journal
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Total 164 results found since Jan 2013.
Role of microtubule-associated signaling in Staphylococcus aureus-induced lung injury.
This study tested the role of microtubules (MT) in the mechanisms of SA-induced ALI. EC dysfunction was accompanied by decrease in acetylated tubulin, MT destabilization, and increased activity of histone deacetylase-6 (HDAC6) as a result of oxidative stress. HDAC6 inhibition using gene-specific siRNA or tubastatin A rescued SA-induced EC barrier disruption monitored by measurements of electrical resistance and macromolecular permeability. SA-induced EC dysfunction was associated with impaired MT-mediated delivery of cytoplasmic linker-associated protein 2 to the cell periphery limiting its interaction with adherens juncti...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Birukova, A., Karki, P., Tian, Y., Sarich, N., Ke, Y., Birukov, K. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Andrographolide inhibits the activation of NLRP3 inflammasome in patients with COPD
Conclusion: Natural product andrographolide inhibited the NLRP3 inflammasome activation in COPD and might be a potential strategy to target COPD excerbations.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Xiao, W., Fu, J.-J., Wang, S.-J., Wang, Y., Miao, T.-W., Mao, B. Tags: Airway pharmacology and treatment Source Type: research
MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signalling
Conclusion: We conclude that intact MKP5 is required for induction of changes in lung fibroblasts in-vitro and during bleomycin-induced lung fibrosis in-vivo. Our results couple MKP5 activity with TGFB1 signaling machinery identifying MKP5 inhibition as a promising therapeutic strategy for experimental and human lung fibrosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tzouvelekis, A., Xylourgidis, N., Min, K., Karampitsakos, T., Ninou, I., Barbayianni, I., Bennett, A., Aidinis, V., Kaminski, N. Tags: Mechanisms of Lung Injury and Repair Source Type: research
TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal
In conclusions, these results suggested that TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal in tumor microenvironment.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hwang, K. E., Oh, S. J., Jeong, E. T., Kim, H. R. Tags: Lung Cancer Source Type: research
Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomes
Conclusion: Lack of CC16 results in enhanced T2 inflammatory responses in both human primary cell culture and a mouse model. CC16 mRNA levels inversely correlated with MUC5AC which was supported by the CC16 knockdown experiments, and significantly associated with clinically relevant asthma outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kraft, M., Ledford, J., Gozdz, J., Li, X., Francisco, D., Manne, A., Guerra, S., Martinez, F., Kaminski, N., Wenzel, S., Meyers, D., Bleecker, E. Tags: Clinical Problems Source Type: research
Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice
Conclusion: Increased expression of Arp2/3 was observed both in IPF fibroblasts and in bleomycin-exposed mouse lungs. CK666 and siARPC2 attenuated profibrotic differentiation of lung fibroblasts. CK666 attenuated bleomycin-induced lung fibrosis in vivo. Arp2/3 Inhibition may be an attractive new therapy for IPF and other fibrotic interstitial lung diseases.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mergault, C., Lisee, F., Tiroille, V., Heuze-VourcH, N., Parent, C., Sizaret, D., Marchand-Adam, S., Plantier, L. Tags: Mechanisms of lung injury and repair Source Type: research
Cigarette Smoke Extract Promotes Human Lung Myofibroblast Differentiation by the Induction of Endoplasmic Reticulum Stress
Conclusion: Our data suggested that CSE promotes lung fibroblast-to-myofibroblast differentiation by the induction of ER stress.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Song, M., Peng, H., Guo, W., Luo, M., Duan, W., Chen, P., Zhou, Y. Tags: Idiopathic interstitial pneumonias Source Type: research
Follistatin-like 1 promotes intermittent hypoxia-induced lung fibroblast activation in vitro and in vivo
Conclusion: Intermittent hypoxia can induce oxidative stress, which in turn leads to fibroblast activation, and this effect may be related to the expression of FSTL1 protein.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Xu, L., Cao, J. Tags: ILD/DPLD of known origin Source Type: research
Lysosomal dysfunction in COPD pathogenesis
Conclusion: These findings suggest that accumulation of dysfunctional lysosome, which is attributed to reduced TRIM16-mediated lysophagy, can be associated with enhanced epithelial cell damage during COPD pathogenesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Saito, N., Araya, J., Ito, A., Hosaka, Y., Ichikawa, A., Kadota, T., Nakano, T., Yoshida, M., Fujita, Y., Utsumi, H., Hashimoto, M., Wakui, H., Minagawa, S., Hara, H., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research
Cigarette smoke decreases E-Cadherin expression downregulating FoxO3 in lung epithelial cells
Epithelial to mesenchymal transition (EMT) is implicated in lung tissue remodeling in Chronic Obstructive Pulmonary Disease (COPD). EMT is characterized by loss of epithelial junctions, including down-regulation of E-cadherin. Several signaling pathways are implicated in EMT, including TGF-β. TGF-β stimulation causes SMAD-independent activation of AKT resulting in phosphorylation and subsequent degradation of forkhead box class O3 (FoxO3). FoxO3 prevents the transcription activity of β-catenin, which controls expression of SNAIL1 and ZEB1, repressors of E-cadherin gene expression. The FoxO3 expression is red...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Di Vincenzo, S., Sangiorgi, C., Ferraro, M., Gjomarkaj, M., Ninaber, D. K., Hiemstra, P. S., Pace, E. Tags: Airway cell biology and immunopathology Source Type: research
Comparison of anticancer effects of a novel histone deacetylase (HDAC) inhibitor CG200745 and SAHA in non-small lung cancer cells
Histone deacetylase (HDAC) inhibition offers the potential for anti-cancer effects in a variety of cancers, since HDAC plays an important role in cancer development and progression. Thus, we demonstrated the therapeutic efficacy of the new HDAC inhibitor, CG200745, in comparison with existing HDAC inhibitors, such as suberoylanilide hydroxamic acid (SAHA) in non-small lung cancer cells.Compared with SAHA, CG200745 had inhibited cell viability and HDACs expression, and induced apoptosis, ROS and mitochondrial dysfunction. CG200745 also significantly reduced tumor volume in vivo compared with SAHA. We observed increased apop...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kim, H.-R., Jung, J.-W., Hwang, K.-E., Park, C., Jeong, E.-T. Tags: Lung cancer Source Type: research
NF-kB activation in cystic fibrosis: The dream of A20
In conclusion, high expression of the repressor DREAM inhibits A20 transcription in CF epithelial cells. Our work suggests an important role of the A20-DREAM axis in (innate) inflammation, providing a new molecular target for the development of innovative anti-inflammatory therapies.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Momtazi, G., Elbanna, A., Finnegan, S., Heritier, M., Lavery, L., Mccollum, K., Naranjo, J., Schock, B. Tags: Airway cell biology and immunopathology Source Type: research
The RNA binding protein HuR regulates the senescence-associated secretory phenotype under conditions of oxidative stress
Conclusion: Gene silencing of HuR in the presence and absence of oxidative stress results in increased expression of inflammatory mediators, MMPs and senescence markers, suggesting HuR may play a role in regulation of the SASP in COPD.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hassibi, S., Baker, J., Donnelly, L., Barnes, P. Tags: Airway cell biology and immunopathology Source Type: research
Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis
Conclusion: These findings suggest that reduced CMA activity may be involved in the mechanism for epithelial cell apoptosis by enhancing CS-induced UPR in COPD pathogenesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hosaka, Y., Araya, J., Fujita, Y., Tsubouchi, K., Minagawa, S., Hara, H., Nakano, T., Ito, A., Ichikawa, A., Saito, N., Kadota, T., Yoshida, M., Hashimoto, M., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research
Investigating the role of AKAP13 on epithelial cell TGFss activation
Conclusion: AKAP13 expression is found predominantly in epithelial cells in the lung. AKAP13 appears to regulate RhoA activation in iHBECs and influence αvβ6 expression. This suggests that it is involved in the RhoA-αvβ6 pathway that drives TGF-β activation in epithelial cells.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Organ, L., Porte, J., John, A., Jenkins, G. Tags: Mechanisms of lung injury and repair Source Type: research
