6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway

Conclusions: Our findings indicate that inhibition of G6PD may have anti-fibrotic effects on pulmonary fibrosis, suggesting that G6PD is implicated as a potential therapeutic target in IPF.Figure: Comparison of hydroxyproline levels in the bleomycin induced lung fibrosis mouse model according to the treatment

Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kim, M., Kim, H.-S., Moon, S.-J., Yoo, H. J., Song, J. W. Tags: Mechanisms of lung injury and repair Source Type: research