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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie
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Total 256 results found since Jan 2013.
FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway.
In conclusion, FAM83D knockdown promoted colorectal cancer cell apoptosis, inhibited cell proliferation, cell migration and invasion, which might be associated with inhibiting the FBXW7/Notch1 signal pathway. Our findings indicated that FAM83D is a promising molecular target for colorectal cancer treatment.
PMID: 28407575 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2017 Category: Drugs & Pharmacology Authors: Mu Y, Zou H, Chen B, Fan Y, Luo S Tags: Biomed Pharmacother Source Type: research
MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis.
In this study, qRT-PCR assay showed that the expressions of miR-155 mRNA in psoriasis tissues were significantly higher than that in normal tissues. The assays about cell growth and proliferation showed that miR-155 knockdown led to a significant decrease in cell proliferation which was determined by MTT assay and colony formation assay compared to those of Lv-NC cells. Flow cytometry analysis showed that depletion of miR-155 could cause cell cycle change and the number of apoptotic cells was significantly increased in Lv-miR155 cells compared with control cells. In addition, the expression of several apoptosis-related fac...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2017 Category: Drugs & Pharmacology Authors: Xu L, Len H, Shi X, Ji J, Fu J, Len H Tags: Biomed Pharmacother Source Type: research
Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts.
CONCLUSIONS: These results indicate that the GILZ-mediated osteogenic signal pathway is involved in the osteogenic effect induced by icariin.
PMID: 28363169 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2017 Category: Drugs & Pharmacology Authors: Lin Z, Jiang ZL, Chen LH, Sun Y, Chen SZ, Zhou P, Xia AX, Jin H, Zhu YW, Chen DY Tags: Biomed Pharmacother Source Type: research
TMF protects chondrocytes from ER stress-induced apoptosis by down-regulating GSK-3 β.
TMF protects chondrocytes from ER stress-induced apoptosis by down-regulating GSK-3β.
Biomed Pharmacother. 2017 Mar 17;89:1262-1268
Authors: Yuan X, Li L, Shi W, Liu H, Huang X, Liu Z, Wu L
Abstract
Endoplasmic reticulum (ER) stress-induced chondrocyte apoptosis plays a critical role in osteoarthritis cartilage degeneration. Previous studies showed that 5,7,3',4'-tetramethoxyflavone (TMF) exhibited chondroprotective activity through inhibiting PGE2-induced ER stress and down regulating the expression of GSK-3β. To further investigate the role of GSK-3β in ER stress-induced chondrocytes apoptosis an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 17, 2017 Category: Drugs & Pharmacology Authors: Yuan X, Li L, Shi W, Liu H, Huang X, Liu Z, Wu L Tags: Biomed Pharmacother Source Type: research
Claudin-1 regulates pulmonary artery smooth muscle cell proliferation through the activation of ERK1/2.
Abstract
Tumor necrosis factor alpha (TNF-α), a crucial inflammatory cytokine, is involved in the pathogenesis of pulmonary arterial hypertension (PAH). TNF-α can induce claudin-1 (CLDN1) expression and CLDN1 has been reported to be associated with the regulation of cellular functions including cell proliferation, migration. Thus, we aimed to explore whether CLDN1 participated in the etiology of PAH. Our study showed that CLDN1 expression was markedly increased in the lungs of rats with monocrotaline(MCT)-induced PAH, especially in the pulmonary arterial smooth muscle sections. We also found that CLDN1 expressio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2017 Category: Drugs & Pharmacology Authors: Cheng X, Wang Y, Chen H, Xu Y, Xiong W, Wang T Tags: Biomed Pharmacother Source Type: research
The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma.
CONCLUSION: Our study provides evidence that inhibiting lncRNA MALAT-1 can improve the chemotherapy sensitivity of DLBCL by enhancing autophagy-related proteins.
PMID: 28292022 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 7, 2017 Category: Drugs & Pharmacology Authors: Li LJ, Chai Y, Guo XJ, Chu SL, Zhang LS Tags: Biomed Pharmacother Source Type: research
Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia.
Abstract
Chronic lymphocytic leukemia (CLL) is characterized by reposition of malignant B cells in the blood, bone marrow, spleen and lymph nodes. It remains the most common leukemia in the Western world. Within the recent years, major breakthroughs have been made to prolong the survival and improve the health of patients. Despite these advances, CLL is still recognized as a disease without definitive cure. New treatment approaches, based on unique targets and novel drugs, are highly desired for CLL therapy. The Identification and subsequent targeting of molecules that are overexpressed uniquely in malignant cells...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 31, 2017 Category: Drugs & Pharmacology Authors: Aghebati-Maleki L, Shabani M, Baradaran B, Motallebnezhad M, Majidi J, Yousefi M Tags: Biomed Pharmacother Source Type: research
LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes.
In conclusion, our study revealed that the coordination between histone demethylases and methyl-transferases might serve as a double lock system to suppress the expression of interferon stimulated genes.
PMID: 28152483 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 29, 2017 Category: Drugs & Pharmacology Authors: Jin Y, Huo B, Fu X, Hao T, Zhang Y, Guo Y, Hu X Tags: Biomed Pharmacother Source Type: research
Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.
Abstract
Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regulation of rat adipose-derived stem cells (rASCs) proliferation and osteogenic differentiation. In the present study, we detected that icariin pro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 21, 2017 Category: Drugs & Pharmacology Authors: Ye Y, Jing X, Li N, Wu Y, Li B, Xu T Tags: Biomed Pharmacother Source Type: research
MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells.
In conclusion, miR-200c was significantly down-regulated in both GC tissues and cell lines, while FN1 presented the opposite trends. Besides, miR-200c inhibited the proliferation, migration and invasion of GC cells through binding to FN1.
PMID: 28113080 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 19, 2017 Category: Drugs & Pharmacology Authors: Zhang H, Sun Z, Li Y, Fan D, Jiang H Tags: Biomed Pharmacother Source Type: research
Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer.
Abstract
Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes). We further validated one circRNA generated from Exon 5-11 of BANP ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 15, 2017 Category: Drugs & Pharmacology Authors: Zhu M, Xu Y, Chen Y, Yan F Tags: Biomed Pharmacother Source Type: research
Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells.
Abstract
Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily results from oxidative stress that causes oxidative damage to the retinal pigment epithelial (RPE) cells. Hesperetin (Hesp) is a common flavanone glycoside compound that has been demonstrated to exhibit a variety of biological and pharmacological properties that include anti-inflammatory and antioxidant properties. The aim of this study is to explore the ability of Hesp to attenuate oxidative damage in hydrogen peroxide (H2O2)-stimulated ARPE-19 cells. The results indicated that Hesp treatment not only increased c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 15, 2017 Category: Drugs & Pharmacology Authors: Zhu C, Dong Y, Liu H, Ren H, Cui Z Tags: Biomed Pharmacother Source Type: research
Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.
CONCLUSION: Our results suggest that the bach1 can be considered as a potent adjuvant in breast cancer therapy.
PMID: 28092843 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2017 Category: Drugs & Pharmacology Authors: Aletaha M, Mansoori B, Mohammadi A, Fazeli M, Baradaran B Tags: Biomed Pharmacother Source Type: research
Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p.
CONCLUSION: LncRNA CCAT1 promotes the proliferation migration and invasion, and reduces cell apoptosis of SO-RB50 and Y79 cells, probably through negative modulation of miR-218-5p. Our study suggested lncRNA CCAT1 as a potential biomarker and therapeutic target for RB.
PMID: 28088735 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 11, 2017 Category: Drugs & Pharmacology Authors: Zhang H, Zhong J, Bian Z, Fang X, Peng Y, Hu Y Tags: Biomed Pharmacother Source Type: research
STARS knockout attenuates hypoxia-induced pulmonary arterial hypertension by suppressing pulmonary arterial smooth muscle cell proliferation.
In this study, we aimed to investigate the role of STARS in the proliferation of pulmonary arterial smooth muscle cells (PASMC) and the potential effect on the progression of pulmonary arterial hypertension (PAH). In this study, we established a PAH mouse model through chronic hypoxia exposure as reflected by the increased RVSP and RVHI. Western blot and RT-qPCR detected the increased STARS protein and mRNA levels in PAH mice. Next, we cultured the primary PASMC from PAH mice. After STARS overexpression in PASMC, STARS, SRF and Egr-1 were up-regulated significantly. The MTT assay revealed an increase in cell proliferation....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 5, 2017 Category: Drugs & Pharmacology Authors: Shi Z, Wu H, Luo J, Sun X Tags: Biomed Pharmacother Source Type: research
