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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie
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Total 256 results found since Jan 2013.
Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism
Biomed Pharmacother. 2022 May 30;152:113199. doi: 10.1016/j.biopha.2022.113199. Online ahead of print.ABSTRACTSepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5) that protects the heart from ischemia/reperfusion injury through upregulation of mitochondrial ubiquitin ligase (MITOL). Gasdermin D (GSDMD)-dependent pyroptosis plays a pivotal role in septic cardiomyopathy by regulating mitochondrial homeostasis. However,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 2, 2022 Category: Drugs & Pharmacology Authors: Xiang Xiong Linhe Lu Zhenyi Wang Jipeng Ma Yalan Shao Yang Liu Mengen Zhai Ping Jin Jian Yang Qijun Zheng Jincheng Liu Lifang Yang Source Type: research
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
CONCLUSION: LBP seems to exert a negative feedback on ERα-mediated estrogen action, impacting on genes involved in thermogenesis. The known decreased estrogen action and negative effects of metabolic endotoxemia may be targeted through LBP downregulation.PMID:35643066 | DOI:10.1016/j.biopha.2022.113156
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2022 Category: Drugs & Pharmacology Authors: Ferran Comas Ramon D íaz-Trelles Aleix Gavald à-Navarro Edward Milbank Nathalia Dragano Samantha Mor ón-Ros Rajesh Mukthavaram Jessica Latorre Francisco Ortega Maria Arnoriaga-Rodriguez N úria Oliveras-Cañellas Wifredo Ricart Priya P Karmali Kiyoshi Source Type: research
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway
This study investigated the effects of BBR on cardiac senescence and its underlying mechanism. Senescent H9c2 cells induced by doxorubicin (DOX) and naturally aged rats were used to evaluate the protective effects of BBR on cardiac senescence. The results showed that BBR protected H9c2 cells against DOX-induced senescence. Exogenous Klotho (KL) exerts similar effects to those of BBR. BBR significantly increased in protein expression of KL, while transfection with KL-specific siRNA (siKL) inhibited the protective effect of BBR against senescence. Both BBR and exogenous KL decreased the levels of reactive oxygen species, inh...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2022 Category: Drugs & Pharmacology Authors: Cong Li Shuang Jiang Hengfei Wang Yuhong Wang Yanxing Han Jiandong Jiang Source Type: research
CXCL12 inhibits hair growth through CXCR4
This study aims to investigate the expression of CXCL12 and its receptor, CXCR4, in the vicinity of hair follicles and their effect on hair growth. CXCL12 was highly expressed in dermal fibroblasts (DFs) and its level was elevated throughout the catagen and telogen phases of the hair cycle. CXCR4 is expressed in the dermal papilla (DP) and outer root sheath (ORS). In hair organ culture, hair loss was induced by recombinant CXCL12 therapy, which delayed the telogen-to-anagen transition and decreased hair length. In contrast, the suppression of CXCL12 using a neutralizing antibody and siRNA triggered the telogen-to-anagen tr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2022 Category: Drugs & Pharmacology Authors: Mei Zheng Sang Ho Oh Nahyun Choi Yong Jin Choi Jino Kim Jong-Hyuk Sung Source Type: research
Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma
Biomed Pharmacother. 2022 Mar 31;149:112888. doi: 10.1016/j.biopha.2022.112888. Online ahead of print.ABSTRACTSynovial sarcoma is typical aggressive malignant without satisfactory treatment outcome in adult series. Cyclin-dependent kinases (CDKs) in transcription have been considered promising molecular targets in cancer. Among these, CDK7 has been shown to play important roles in the pathogenesis of malignancies. However, the modulation mechanism of CDK7-regulated transcription in synovial sarcoma is unknown. In the present study, we aim to determine the expression and function of CDK7 in the transcription cycle of RNA po...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2022 Category: Drugs & Pharmacology Authors: Xiaoyang Li Dylan C Dean Jin Yuan Thomas H Temple Jonathan C Trent Andrew E Rosenberg Shengji Yu Francis J Hornicek Zhenfeng Duan Source Type: research
SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression
In this study, we designed and synthesized a small interfering RNA (siRNA, named siRNA-circFARSA), which specifically inhibits circFARSA expression. Using liposomes and porous silicon nanoparticles (pSiNPs) as siRNA delivery system, we prepared liposome-siRNA-circFARSA and pSiNP-PEI-siRNA-circFARSA and investigated their anti-cancer mechanism by quantitative real-time PCR and western blotting. Cell proliferation curves and transwell migration assays were performed to investigate the effect of siRNAs proliferation and migration capabilities of cancer cells. Patient-derived tumor xenograft mouse models were used to investiga...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 1, 2022 Category: Drugs & Pharmacology Authors: Huixiao Yuan Xin Huang Qingqing Li Cici Luo Chenyu Lin Shuxian Zhang Yaguang Zhang Zhilin Yan Ning Du Zhongmin Liu Hua Jiang Bingdi Chen Source Type: research
Valsartan- and melatonin-supported adipose-derived mesenchymal stem cells preserve renal function in chronic kidney disease rat through upregulation of prion protein participated in promoting PI3K-Akt-mTOR signaling and cell proliferation
In conclusion, Mel/Val facilitated-ADMSCs preserved renal architecture and function in CKD rat through promoting PrPC to regulate the cell proliferation/oxidative-stress/cell-stress signalings.PMID:34923336 | DOI:10.1016/j.biopha.2021.112551
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 19, 2021 Category: Drugs & Pharmacology Authors: Chih-Chao Yang Pei-Hsun Sung Kuan-Hung Chen Han-Tan Chai John Y Chiang Sheung-Fat Ko Fan-Yen Lee Hon-Kan Yip Source Type: research
